Exploration of variation in effects
No. A2
Task: If applicable, describe any methods used to explore variation in effects by study or participant level characteristics (such as estimation of interactions between effect and covariates). State all participantlevel characteristics that were analysed as potential effect modifiers, and whether these were pre-specified.
Text: Subgroup analyses are undertaken for baseline variables, as relevant to each meta-analysis and these are described in the specific reports of each review. Tests for interaction are done across the effects estimates for the subgroups.