Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

REVEAL was a randomised trial investigating the effects of adding anacetrapib (a potent CETP inhibitor) to effective LDL-lowering treatment with atorvastatin. Between 2011 and 2013 REVEAL recruited over 30,000 men and women who already had some form of circulatory disease. Participants were recruited from over 430 hospitals and clinics in the UK, North America, China, Germany, Italy and Scandinavia. All study participants were given atorvastatin (a commonly used "statin" drug) to ensure good control of LDL ("bad") cholesterol. Participants also received either anacetrapib 100mg or matching placebo (dummy) tablets daily (allocated randomly).

The primary aim of the study was to see whether fewer participants given anacetrapib had heart attacks, revascularization procedures or died from coronary heart disease than those given the placebo tablets. Secondary aims included assessment of the safety of anacetrapib, as well as the effects on a number of other outcomes.

The trial was coordinated at CTSU, with academic collaborators leading regional coordinating centres in Europe, North America and China. The University of Oxford is the trial Sponsor. Financial support has been provided by Merck Sharp & Dohme.

Results were published in 2017 and showed that anacetrapib lowers the risk of heart attack and related cardiovascular complications among high risk patients who are receiving intensive statin treatment. The treatment was well tolerated and there were no major safety concerns.

The REVEAL post-trial follow-up results were published in December 2021. They showed that the beneficial effects of anacetrapib on major coronary events increased with longer follow-up, with no adverse effects emerging for non-vascular mortality or morbidity. These findings illustrate the importance of sufficiently long treatment and follow-up duration in randomised trials of lipid-modifying agents to assess their full benefits and harms.

Long-term follow-up information


All participants stopped study treatment prior to February 2017 and direct participant follow-up was completed in April 2019. However, in the UK we continue to collect information on health outcomes via central data registries and NHS sources.

Our team

  • Martin Landray
    Martin Landray

    Professor of Medicine and Epidemiology

  • Louise Bowman
    Louise Bowman

    Professor of Medicine and Clinical Trials, and Honorary Consultant Physician (Lipidology)

  • Rory Collins
    Rory Collins

    Head of Oxford Population Health and BHF Professor of Medicine and Epidemiology

  • Jemma Hopewell
    Jemma Hopewell

    Professor of Precision Medicine & Epidemiology


Unrestricted grant from Merck, Sharp and Dohme (see Unit's funding policy here)

Trial registrations

Selected publications

Related research themes