Professor Martin Landray
- Modelling adverse event processing in clinical trials Research Group
- Can routine healthcare data be used to efficiently and reliably follow-up participants in renal trials: analyses using linked data from 2 large renal trials Research Group
- Assessing contemporary risks of vascular interventions in The Global Comparators Project – An international collaborative dataset comprising 2M admissions across 41 hospital groups Research Group
- HPS3 / TIMI 55 - REVEAL : Randomised EValuation of the Effects of Anacetrapib through Lipid-modification Research Group
- SHARP: Study of Heart and Renal Protection Research Group
- Research Regulation Research Group
MB ChB, PhD, FRCP, FHEA, FASN, FBPhS, FESC
Professor of Medicine and Epidemiology; Deputy Director, Big Data Institute
- MRC PHRU Programme Leader
- Honorary Consultant Physician
- Cardiology, Cardiac and Thoracic Surgery Directorate
- Oxford University Hospitals NHS Foundation Trust
Martin Landray is Professor of Medicine and Epidemiology within the Nuffield Department of Population Health and Deputy Director of the Big Data Institute within the Li Ka Shing Centre for Health Information and Discovery.
His work seeks to further understanding of the determinants of common life-threatening and disabling diseases through the design, conduct and analysis of efficient, large-scale epidemiological studies (including clinical trials) and the widespread dissemination of both the results and the scientific methods used to generate them. He leads international trials that have enrolled over 65,000 individuals with cardiovascular or kidney disease from 18 countries across 4 continents, and the results of completed studies have changed regulatory drug approvals, influenced clinical guidelines and changed prescribing practice to the benefit of patients. He also oversees the development of systems for recruitment, data collection (including integrated measurement devices and record linkage), analysis and data sharing for UK Biobank, a prospective cohort study of 500,000 middle-aged men and women.
In addition to leading his own research, he is heavily involved in efforts to streamline clinical trials, working with national and international organizations (including FDA, EMA, MHRA, MRC) to facilitate high quality research is efficient in providing robust information for healthcare decision-making. He is a member of the Steering Committee of the Clinical Trial Transformation Initiative (a FDA initiative, coordinated by Duke University) and a leader of the CTTI Monitoring and Quality by Design Projects. He was previously an advisor to the FDA’s initiative to develop standardized definitions for cardiovascular endpoints in clinical trials, a member of the NIHR Commissioning Board, and a member of a UK Department of Health / MRC / MHRA project to promote risk-based monitoring of clinical trials.
Martin Landray completed medical training at University of Birmingham (UK) and specialist training in Clinical Pharmacology & Therapeutics, and General Internal Medicine at University of Birmingham. He continues to practise clinical medicine as an Honorary Consultant Physician in the Cardiology, Cardiac and Thoracic Surgery Directorate at Oxford University Hospitals NHS Trust. He is a Fellow of the Royal College of Physicians of London, the Higher Education Academy, the American Society of Nephrology, the British Pharmacological Society, and the European Society of Cardiology.
Smoking and Adverse Outcomes in Patients With CKD: The Study of Heart and Renal Protection (SHARP).
Staplin N. et al, (2016), Am J Kidney Dis, 68, 371 - 380
Enhancing clinical evidence by proactively building quality into clinical trials.
Meeker-O'Connell A. et al, (2016), Clin Trials, 13, 439 - 444
Impact of renal function on the effects of LDL cholesterol lowering with statin-based regimens: a meta-analysis of individual participant data from 28 randomised trials
Herrington W. et al, (2016), The Lancet Diabetes and Endocrinology
Improving clinical trials for cardiovascular diseases: a position paper from the Cardiovascular Round Table of the European Society of Cardiology.
Jackson N. et al, (2016), Eur Heart J, 37, 747 - 754
Impact of Educational Attainment on Health Outcomes in Moderate to Severe CKD.
Morton RL. et al, (2016), Am J Kidney Dis, 67, 31 - 39
IN the News
Lectures, webcasts and interviews
Big Trials, Big Data, Big Potential: population health research in the 21st century
Inaugural Lecture, University of Oxford, November 2015
New Technologies for Healthcare Research
Oxford Martin School, University of Oxford, January 2016
Big Data for Efficient Clinical Trials
National Academy of Medicine, Washington DC, October 2015
Big Data in Biomedicine
Interview, Stanford Medicine, May 2015
Quality by Design for Clinical Trials
Clinical Trial Transformation Initiative, Bethesda, April 2015
Big Data in Biomedicine
Interview, Stanford Medicine, May 2014
Big Data and Drug Discovery
University of Oxford Alumni, October 2013