Professor Jemma C. Hopewell
- HPS2 -THRIVE: Treatment of HDL to Reduce the Incidence of Vascular Events
- HPS3 / TIMI 55 - REVEAL : Randomised EValuation of the Effects of Anacetrapib through Lipid-modification
- HPS: Heart Protection Study
- PROCARDIS Sibling-pair Studies of Genetic Determinants of MI
- Trials Methodology
- Clinical Trial Service Unit and Epidemiological Studies Unit (CTSU)
- Big Data Institute (BDI)
BSc (Hons) MSc PhD (Cantab) FESC
Professor of Precision Medicine & Epidemiology
- British Heart Foundation IBSR Fellow
- MSc in Global Health Science Module Lead: Genetic Epidemiology
- EPSRC Centre for Doctoral Training in Health Data Science Module Lead: Genetics
- Visiting Professor, Department of Human Genetics, McGill University
Interests: Cardiovascular Disease, Genetic Epidemiology, Pharmacogenetics, Clinical Trials
Professor Jemma Hopewell leads a team of genetic epidemiologists, clinical fellows, medical statisticians and bioinformaticians in a programme of research focusing on the use of genetic and clinical trial-based studies to investigate the causes and treatments for cardiovascular disease and arrhythmias. She has particular interests in determining predictors of patient response to therapy, using genetics to improve our understanding of drug targets and disease mechanisms, and genomic characterisation of vascular disease and its risk factors, particularly Lp(a).
Jemma leads and collaborates on numerous projects involving CTSU's vascular mega-trials (e.g. HPS, SEARCH, THRIVE, REVEAL), large-scale studies and biobanks (e.g. PROCARDIS, UK Biobank), and international consortia (e.g. METASTROKE, CARDIoGRAMplusC4D, GoLEAD, CATCH-ME). She is a member of the Lp(a) Foundation Scientific Advisory Board, of various clinical trial and genetic study Steering and Analysis Committees, and is currently the Chair of METASTROKE (a collaboration of the International Stroke Genetics Consortium), as well as co-ordinating the MSc in Global Health Science Genetic Epidemiology module.
Hopewell Group - Current Members
- Research Staff
Federico Murgia, Bioinformatician
Dr Alex Stiby, Senior Genetic Epidemiologist & Statistical Programmer
Dr Elsa Valdes-Marquez, Senior Medical Statistician
Adam Von Ende, Medical Statistician
- DPhil Students
Dr Christian Camm, British Heart Foundation Clinical Research Training Fellow
Dr Parag Gajendragadkar, British Heart Foundation Clinical Research Training Fellow
Sam Smith, Personal Assistant
Long-term safety and efficacy of anacetrapib in patients with atherosclerotic vascular disease.
HPS3/TIMI55-REVEAL Collaborative Group Writing Committee: None. et al, (2021), Eur Heart J
Are polygenic risk scores for systolic blood pressure and LDL-cholesterol associated with treatment effectiveness, and clinical outcomes among those on treatment?
Tapela NM. et al, (2021), Eur J Prev Cardiol
The impact of atrial fibrillation and stroke risk factors on left atrial blood flow characteristics.
Spartera M. et al, (2021), Eur Heart J Cardiovasc Imaging
Robust estimates of heritable coronary disease risk in individuals with type 2 diabetes.
Grace C. et al, (2021), Genet Epidemiol
Genome-Wide Association Study of Peripheral Artery Disease.
van Zuydam NR. et al, (2021), Circ Genom Precis Med