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ACST-2 (ISRCTN21144362) is an international randomised trial, coordinated by the ACST-2 office at the University of Oxford, comparing carotid endarterectomy (CEA) with carotid stenting (CAS) for long-term stroke prevention.

Patients in ACST-2 have tight asymptomatic carotid stenosis. We are comparing both the immediate hazards of the procedures when carried out by experienced doctors and the subsequent stroke rates over the next five to ten years.