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6. Data available for sharing

For full details of available data please review the online MCPS Data Showcase. The Showcase displays all the data types currently available, in a grouped format (i.e. not at the individual participant level), along with further information about each data field (for example, background information about how measures were taken). Genetic variation can be viewed using the MCPS online Variant Browser.

Details of data available to researchers worldwide

Baseline data (1998 - 2004) available for 159,517 participants

Month and year of recruitment

Socio-demographic

  • age
  • sex
  • area of residence
  • marital status
  • educational achievement
  • occupation
  • income
  • health service provider

Lifestyle characteristics

  • smoking
  • passive smoking
  • alcohol consumption
  • physical activity
  • sleep duration
  • fruit/vegetable intake
  • fried food intake
  • type of cooking oil used

Prior diseases and medication

Reproductive history (women)

  • menopausal status
  • hysterectomy
  • oophorecomy
  • hormone replacement therapy
  • contraceptive use
  • age at first sexual relationship
  • age at first pregnancy
  • number of pregnancies

Physical measurements

  • height
  • weight
  • waist circumference
  • hip circumference
  • systolic blood pressure
  • diastolic blood pressure

Blood samples

  • time of blood sampling
  • time since last meal
  • glycosylated haemoglobin

Resurvey data (2015 - 2019) available for 10,143 participants. Similar data to that collected at baseline plus

Additional questionnaire data

  • diabetes control questions
  • diabetes consequences (e.g eyes, amputations, dialysis)
  • fractures/falls
  • treatment for breast cancer
  • additional dietary questions (e.g sugary drinks, added salt, meat, fish, desserts, diets)
  • cognitive function (MMSE)

Additional measurements

  • bioimpedance (fat mass, fat free mass, muscle mass, muscle score, bone mass, body water, degree of obesity, visceral fat rating, basal metabolic rate, metabolic age, Rohrer's index.)

Additional samples

  • time of urine sampling
  • urinary creatinine
  • urinary albumin

Baseline NMR metabolomic data using the Nightingale Health platform First release: 40,297 participants

 14 Lipoprotein subclasses

  • XXL VLDL
  • XL VLDL
  • L VLDL
  • M VLDL
  • S VLDL
  • XS VLDL
  • IDL
  • L LDL
  • M LDL
  • S LDL
  • XL HDL
  • L HDL
  • M HDL
  • S HDL

Lipoprotein mean particle sizes and apolipoproteins

  • VLDL-D
  • LDL-D
  • HDL-D
  • Apo A1
  • Apo B

Cholines and glycolysis-related

  • total cholines
  • phosphatidylcholine
  • sphingomyelin
  • lactate
  • citrate
  • glucose

7 Lipid measures for each subclass

  • particle number
  • cholesterol
  • free cholesterol
  • esterified cholesterol
  • triglycerides
  • phosphorolipids
  • total lipids

Fatty acids

  • polyunsaturated fatty acids
  • monosaturated fatty acids
  • saturated fatty acids
  • docosahexaenoic acid
  • linoleic acid
  • omega-3
  • omega-6
  • total fatty acids

Amino acids

  • alanine
  • gluatmine
  • histidine
  • isoleucine
  • leucine
  • valine
  • phenylalanine
  • tyrosine

Ketone bodies, inflammation and kidney function

  • acetate
  • acetone
  • β-hydroxy-butyrate
  • albumin
  • creatinine
  • glycoprotein acetyls

Genomic Data

Described fully in Ziyatdinov et al. 2023 

 

Genome–wide genotyping with the Illumina Global Screening Array (GSA) version 2

Non-filtered dataset (140,831 participants)
650,381 variants: 619,501 autosomal variants; 30,101 sex chromosome variants; 779 mitochondrial variants.

Quality controlled dataset (138,511 participants)
559,923 variants: 539,315 autosomal variants; 19,954 sex chromosome variants; 654 mitochondrial variants.

 
Whole Exome Sequencing (WES)

Non-filtered dataset (141,046 participants)
13,331,228 variants: 12,957,291 autosomal variants; 368,300 chromosome X variants; 5,637 chromosome Y variants
 
Whole Genome Sequencing (WGS)

Non-filtered dataset (9950 participants)
158,464,363 variants:151,639,445 autosomal variants; 6,342,270 chromosome X variants; 482,648 chromosome Y variants.

Phased WGS Imputation Reference Panel (MCPS10k) 9,948 whole genome sequenced phased samples

Total of 134,337,444 variants distributed across 22 autosomes and chromosome X

Data available in four file formats.
 
TopMed Imputed
Non-filtered dataset (140,831 participants)
307,624,124 variants: 292,293,083 autosomal variants; 15,331,041 chromosome X variants.

mortality data (up to 30 september 2022)

  • date of death
  • ICD-10 underlying cause
  • ICD-10 contributory causes
  • timing/duration of diseases
  • location of death
  • seen by doctor before death.

Apo A1=apolipoprotein A1; Apo B=apolipoprotein B; HDL=high density lipoproteins; HDL−D=high density lipoprotein particle diameter; IDL=intermediate density lipoproteins; L=large; LDL=low density lipoproteins; LDL−D=low density lipoprotein particle diameter; M=medium; S=small; VLDL=very low density lipoproteins; VLDL−D=very low density lipoprotein particle diameter; XL=very large; XS=very small; XXL=extremely large.

additional data currently available only to researchers in mexico

NMR metabolomic data using the Nightingale Health platform second release: 152833 participants at baseline and 9657 participants at resurvey

All metabolites as listed for the first release plus Phosphoglycerides, Pyruvate, Aceto-acetate and Clinical LDL-C.