6. Data available for sharing

For full details of available data please review the online MCPS Data Showcase. The Showcase displays all the data types currently available, in a grouped format (i.e. not at the individual participant level), along with further information about each data field (for example, background information about how measures were taken). Genetic variation can be viewed using the MCPS online Variant Browser.

Baseline data (1998-2004)

Available for 159,517 participants

Month and year of recruitment

Socio-demographic

Age
Sex
Area of residence
Marital status
Educational achievement
Occupation
Income
Health service provider
Social development Index (SDI)

Lifestyle characteristics

Smoking
Passive smoking
Alcohol consumption
Physical activity
Sleep duration
Fruit/vegetable intake
Fried food intake
Type of cooking oil used

Prior diseases and medication

Reproductive history (women)

Menopausal status
Hysterectomy
Oophorectomy
Hormone replacement therapy
Contraceptive use
Age at first sexual relationship
Age at first pregnancy
Number of pregnancies

Physical measurements

Height
Weight
Waist circumference
Hip circumference
Systolic blood pressure
Diastolic blood pressure

Blood samples

Time of blood sampling
Time since last meal
Glycosylated haemoglobin

Clinical Chemistry Pilot data*

Albumin
Alanine transaminase
Apolipoprotein A
Apolipoprotein B
Aspartate transaminase
Total Cholesterol
Creatinine
Cystatin C
gamma-glutamyl transferase
hs-C-reactive protein
Triglycerides
Lipoprotein(a)
High density lipoprotein
Low density lipoprotein
Estimated glomerular filtration rate

^{*1041 participants only}

Resurvey data (2015-2019)

Available for 10,143 participants. Similar data to that collected at baseline plus:

Additional questionnaire data

Diabetes control questions
Diabetes consequences (eg, eyes, amputations, dialysis)
Fractures/fall
Treatment for breast cancer
Additional dietary questions (eg, sugary drinks, added salt, meat, fish, desserts, diets)
Cognitive function (MMSE)

Additional measurements

Bioimpedance (fat mass, fat free mass, muscle mass, muscle score, bone mass, body water, degree of obesity, visceral fat rating, basal metabolic rate, metabolic age, Rohrer’s index)
Pulse rate

Additional samples

Time of urine sampling
Urinary creatinine
Urinary albumin

Baseline NMR metabolomic data using the Nightingale Health platform

First release: 40,297 participants

14 Lipoprotein subclasses

XXL VLDL
L LDL
XL VLDL
M LDL
L VLDL
S LDL
M VLDL
XL HDL
S VLDL
L HDL
XS VLDL
M HDL
IDL
S HDL

7 Lipid measures for each subclass

Particle number
Triglycerides
Cholesterol
Phospholipids
Free cholesterol
Total lipids
Esterified cholesterol

Lipoprotein mean particle sizes & apolipoproteins

VLDL-D
Apo A1
LDL-D
Apo B
HDL-D

Fatty acids

Polyunsaturated fatty acids
Monounsaturated fatty acids
Saturated fatty acids
Docosahexaenoic acid
Linoleic acid
Omega-3
Omega-6
Total fatty acids

Cholines and glycolysis-related

Total cholines
Lactate
Phosphatidylcholine
Citrate
Sphingomyelin
Glucose

Ketone bodies, inflammation and kidney function

Acetate
Albumin
Acetone
Creatinine
β-hydroxy-butyrate
Glycoprotein acetyls

Genomic Data

Genome–wide genotyping with the Illumina Global Screening Array (GSA) version¥

Non-filtered dataset (140,831 participants)
650,381 variants: 619,501 autosomal variants; 30,101 sex chromosome variants; 779 mitochondrial variants.
Quality controlled dataset (138,511 participants)
559,923 variants: 539,315 autosomal variants; 19,954 sex chromosome variants; 654 mitochondrial variants.

TOPMed Imputed¥

Non-filtered dataset (140,831 participants)
307,624,124 variants: 292,293,083 autosomal variants; 15,331,041 chromosome X variants.

Genetic Risk Score Instruments

Type 2 Diabetes*
Adiposity§
Blood Pressure¶
Coronary heart disease†

Genetic Derived Variables

Genomic ancestry‡
Relatednessⱽ
Genetic principal componentsⱽ

Linkage Disequilibrium Scoresⱽ

Covariate-adjusted linkage disequilibrium (LD) scores for 18.8 million variants (MAF ≥ 0.1%) estimated from whole-genome sequence data in 9,764 MCPS participants using cov-LDSC.

Whole Exome Sequencing (WES) ¥

Non-filtered dataset (141,046 participants)
13,331,228 variants: 12,957,291 autosomal variants; 368,300 chromosome X variants; 5,637 chromosome Y variants

Whole Genome Sequencing (WGS) ¥

Non-filtered dataset (9950 participants)
158,464,363 variants:151,639,445 autosomal variants; 6,342,270 chromosome X variants; 482,648 chromosome Y variants.

Phased WGS Imputation Reference Panel (MCPS10k) ¥

9,948 whole genome sequenced phased samples
Total of 134,337,444 variants distributed across 22 autosomes and chromosome X
Data available in four file formats.

^{Apo A1=apolipoprotein A1; Apo B=apolipoprotein B; HDL=high density lipoproteins; HDL−D=high density lipoprotein particle diameter; IDL=intermediate density lipoproteins; L=large; LDL=low density lipoproteins; LDL−D=low density lipoprotein particle diameter; M=medium; S=small; VLDL=very low density lipoproteins; VLDL−D=very low density lipoprotein particle diameter; XL=very large; XS=very small; XXL=extremely large. ¥Nature 2023:622;784-793. *Lancet Reg Health Am. 2025;45:101082. §BMI: Int J Epidemiol. 2025;54(4). ¶Hypertension. 2025;82(11):1896–1905. †Eur J Prev Cardiol. 2026;33(3):415–423. ‡https://www.medrxiv.org/content/10.1101/2025.09.09.25335237v1. ⱽhttps://www.medrxiv.org/content/10.64898/2026.06.23.26356360v.}

Mortality data (up to 30th September 2022)

Date of death
ICD-10 underlying cause
ICD-10 contributory causes
Timing/duration of diseases
Location of death
Seen by doctor before death

Additional data currently available only to researchers in Mexico

NMR metabolomic data using the Nightingale Health platform

Second release: 152,833 participants at baseline and 9657 participants at resurvey

All metabolites as listed for the first release plus Aceto-acetate, Clinical LDL-C, and, Glycine and Pyruvate.