Sarah Clark
MRC PHRU Research Fellow
Sarah Clark is a Research Fellow within the Wolfson Laboratories. She coordinates the research and assay development programme and is a member of the senior laboratory management team.
Her main areas of research are the design and conduct of methodological studies to establish appropriate sample collection, transport and storage methods for large blood-based epidemiological studies and the development of new analytical methods suitable for high-throughput testing.
Examples of projects include the investigation of analyte stability in mailed blood or urine; stabilisation of homocysteine and phosphate in transported blood samples; stability of analytes in long-term frozen samples; development of a modified beta quantification reference method for accurate measurement of LDL-cholesterol; and investigation of assay and sample suitability for measurement of FGF-23.
In addition to supporting CTSU projects, Sarah actively supports collaboration with external groups including the UK Biobank, the Cancer Council of New South Wales and the London School of Hygiene and Tropical Medicine.
Sarah studied Chemistry at Oxford University and joined the Clinical Trial Service Unit & Epidemiological Studies Unit (CTSU) in 1994 to undertake a DPhil in Clinical Chemistry and Epidemiology, working on the ISIS-3 case-control study of biochemical risk factors for myocardial infarction.
Recent publications
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Infectious pathogens and risk of esophageal, gastric and duodenal cancers and ulcers in China: A case-cohort study.
Journal article
Kartsonaki C. et al, (2024), Int J Cancer, 154, 1423 - 1432
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The structure of the Caenorhabditis elegans TMC-2 complex suggests roles of lipid-mediated subunit contacts in mechanosensory transduction.
Journal article
Clark S. et al, (2024), Proceedings of the National Academy of Sciences of the United States of America, 121
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Preoperative N-terminal pro-B-type natriuretic peptide and myocardial injury after stopping or continuing renin–angiotensin system inhibitors in noncardiac surgery: a prespecified analysis of a phase 2 randomised controlled multicentre trial
Journal article
Gutierrez del Arroyo A. et al, (2024), British Journal of Anaesthesia
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Cryo-EM structures reveal native GABAA receptor assemblies and pharmacology.
Journal article
Sun C. et al, (2023), Nature, 622, 195 - 201
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Large-scale growth of C. elegans and isolation of membrane protein complexes.
Journal article
Clark S. et al, (2023), Nature protocols, 18, 2699 - 2716