Dr Najaf Amin
Senior Research Associate
Dr. Amin did her masters in statistics from Quaid-e-Azam University Islamabad, Pakistan in 2001. She moved to the Netherlands to pursue higher studies in 2005 on a scholarship awarded by the government of Pakistan. She did her Doctor of Science (DSc) in genetic epidemiology from the Netherlands Institute of Health Sciences in 2007 and received her PhD degree in genetic epidemiology from the Erasmus University Rotterdam, the Netherlands in 2011. From 2011 to 2014 she worked as a post doctoral researcher at the Department of Epidemiology at Erasmus Medical Center, Rotterdam. In 2014 she was promoted to become an assistant professor at the same department. In November 2019 she accepted a senior researcher position at the Nuffield Department of Population Health.
Her main area of research is identifying biomarkers for neuro-psychiatric traits using serum/plasma-based and single cell-based multi-omics research including genomics, epigenomics, transcriptomics, proteomics and metabolomics as well as gut microbiome. Further, she is interested in identifying causal relationships using Mendelian Randomisation and translation of her findings using cell-based research.
She is adept in using contemporary biomarker-mapping techniques related to genomics as well as other omics. She works with genomics data (array and sequence) generated by UK Biobank data and single cell-based transcriptomics, proteomics and metabolomics data in the Alzheimer's Disease Apolipoprotein Pathology for Treatment Elucidation and Development (ADAPTED) consortium. She has over 300 scientific research papers published in various international journals.
Genetic association study of childhood aggression across raters, instruments, and age
Ip HF. et al, (2021), Translational Psychiatry, 11
Genome-wide association study of frontotemporal dementia identifies a C9ORF72 haplotype with a median of 12-G4C2 repeats that predisposes to pathological repeat expansions.
Reus LM. et al, (2021), Transl Psychiatry, 11
Continuity of Genetic Risk for Aggressive Behavior Across the Life-Course.
van der Laan CM. et al, (2021), Behavior genetics, 51, 592 - 606
Association of mitochondrial variants and haplogroups identified by whole exome sequencing with Alzheimer's disease.
Zhang X. et al, (2021), Alzheimers Dement
Plasma amyloid β levels are driven by genetic variants near APOE, BACE1, APP, PSEN2: A genome-wide association study in over 12,000 non-demented participants.
Damotte V. et al, (2021), Alzheimers Dement