Professor Louise Bowman
Research groups
- AMALFI - Active Monitoring for Atrial Fibrillation
- ASCEND: A Study of Cardiovascular Events iN Diabetes
- ORION-4
- Research regulation
- REVEAL : Randomised Evaluation of the Effects of Anacetrapib through Lipid-modification
- SEARCH: Study of the Effectiveness of Additional Reductions in Cholesterol and Homocysteine
- Trials methodology
Websites
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Oxford University Hospitals Trust
Honorary Consultant in Lipidology
Louise Bowman
BA, MBBS, MD, FRCP
Professor of Medicine and Clinical Trials, and Honorary Consultant Physician (Lipidology)
- Co-director Clinical Trial Service Unit & Epidemiological Studies Unit
Louise Bowman is Professor of Medicine and Clinical Trials at the Clinical Trial Service Unit & Epidemiological Studies Unit (CTSU). Her specialist clinical background is in diabetes and endocrinology. She has particular research interests in cardiovascular disease in diabetes, and maintains her clinical practice with regular specialist lipid clinics.
She is Chief Investigator for the ORION-4 trial which is assessing the effects of inclisiran on clinical outcomes among 15,000 people with atherosclerotic cardiovascular disease, and for the AMALFI trial, which is assessing the value of screening for undiagnosed atrial fibrillation in high-risk individuals.
Professor Bowman was also Co-principal Investigator for the ASCEND trial, which studied the effects of aspirin and of omega-3 fatty acid supplementation for the primary prevention of cardiovascular disease in 15,000 people with diabetes, and for the REVEAL study, an international clinical trial that assessed the efficacy and safety of the CETP-inhibitor, anacetrapib, in 30,000 high-risk individuals.
Through her work on large-scale trials in cardiovascular disease she has developed a specialist interest in clinical trials methodology with a particular focus on the development, application and widespread promotion of methods to enhance the design and conduct of trials to ensure high quality outputs and reliable results at low cost. She is Co-Course Director for the MSc in Clinical Trials which is a part-time distance learning course that provides in-depth training in the principles and practice of conducting large-scale, randomised clinical trials.
Recent publications
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Effects of aspirin and omega-3 fatty acids on composite and subdomain scores from the NEI-VFQ-25 questionnaire: the ASCEND-Eye randomized controlled trial.
Sammons EL. et al, (2024), BMC Ophthalmol, 24
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ASCEND-Eye: Effects of Aspirin on Diabetic Retinopathy.
Sammons EL. et al, (2024), Ophthalmology, 131, 771 - 779
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ASCEND-Eye: Effects of Omega-3 Fatty Acids on Diabetic Retinopathy.
Sammons EL. et al, (2024), Ophthalmology, 131, 526 - 533
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Effects of statin therapy on diagnoses of new-onset diabetes and worsening glycaemia in large-scale randomised blinded statin trials: an individual participant data meta-analysis.
Cholesterol Treatment Trialists’ (CTT) Collaboration. Electronic address: ctt@ndph.ox.ac.uk None. and Cholesterol Treatment Trialists’ (CTT) Collaboration None., (2024), Lancet Diabetes Endocrinol, 12, 306 - 319
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Thromboxane biosynthesis and future events in diabetes: the ASCEND trial.
Petrucci G. et al, (2024), Eur Heart J, 45, 1355 - 1367