Professor Jane Armitage
- ASCEND: A Study of Cardiovascular Events iN Diabetes
- BEST-D: Biochemical Efficacy and Safety Trial of Vitamin D
- HPS: Heart Protection Study
- HPS2 -THRIVE: Treatment of HDL to Reduce the Incidence of Vascular Events
- SEARCH: Study of the Effectiveness of Additional Reductions in Cholesterol and Homocysteine
- CTT: Cholesterol Treatment Trialists' Collaboration
- Trials Methodology
- Research Regulation
- Oxford Cholesterol Study
- LENS: Lowering Events in Non-proliferative retinopathy in Scotland
Professor of Clinical Trials and Epidemiology, and Honorary Consultant in Public Health Medicine
- MRC PHRU Programme Leader
Jane Armitage is Professor of Clinical Trials and Epidemiology and Honorary Consultant in Public Health Medicine. In addition, she is Director of Training and Career Development for the Nuffield Department of Population Health.
She joined the Clinical Trial Service Unit, now part of NDPH, in 1990 having qualified in clinical medicine in 1979. She worked in a variety of specialties over several years with particular experience in respiratory medicine, geriatrics and diabetes. Since joining CTSU she has co-ordinated and been chief investigator for a series of large-scale randomised clinical trials in cardiovascular disease including the 20,000 participant MRC/BHF Heart Protection Study, the 12,000 patient SEARCH and 25,000 HPS2-THRIVE study, which are trials of lipid modification in people with or at risk of vascular disease. In addition she is Chief Investigator for the BHF-supported ASCEND trial of aspirin and fish oils involving 15,000 people with diabetes. She collaborates with other epidemiologists and statisticians in NDPH on a variety of genetic and other risk factor studies based on the trial cohorts. She also continues a clinical role in the Lipid Clinic at the Oxford University Hospital NHS Trust and has a particular interest in the safety of statins. Her main research interests are in lipids and the epidemiology of cardiovascular and other chronic diseases including osteoporosis.
Effects of extended-release niacin with laropiprant in high-risk patients.
HPS2-THRIVE Collaborative Group None. et al, (2014), N Engl J Med, 371, 203 - 212
Effects of homocysteine-lowering with folic acid plus vitamin B12 vs placebo on mortality and major morbidity in myocardial infarction survivors: a randomized trial.
Study of the Effectiveness of Additional Reductions in Cholesterol and Homocysteine (SEARCH) Collaborative Group None. et al, (2010), JAMA, 303, 2486 - 2494
The safety of statins in clinical practice.
Armitage J., (2007), Lancet, 370, 1781 - 1790
MRC/BHF Heart Protection Study of cholesterol lowering with simvastatin in 20,536 high-risk individuals: a randomised placebo-controlled trial.
Heart Protection Study Collaborative Group None., (2002), Lancet, 360, 7 - 22
Associations of Omega-3 Fatty Acid Supplement Use With Cardiovascular Disease Risks: Meta-analysis of 10 Trials Involving 77 917 Individuals.
Aung T. et al, (2018), JAMA Cardiol, 3, 225 - 234
Impact of Apolipoprotein(a) Isoform Size on Lipoprotein(a) Lowering in the HPS2-THRIVE Study.
Parish S. et al, (2018), Circ Genom Precis Med, 11
Effects of Vitamin D on Blood Pressure, Arterial Stiffness, and Cardiac Function in Older People After 1 Year: BEST-D (Biochemical Efficacy and Safety Trial of Vitamin D).
Clarke RJ. et al, (2017), Journal of the American Heart Association, 6
Factors influencing recruitment in large randomised trials
Edwards D. et al, (2017), TRIALS, 18
Telephone support for mail based recruitment and follow-up in a large randomized trial
Chen F. et al, (2017), TRIALS, 18