Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

Accept all cookies Reject all non-essential cookies Find out more

6. Data available for sharing

Details of data - available to researchers worldwide

For full details of available data please review the online MCPS Data Showcase. The Showcase displays all the data types currently available, in a grouped format (i.e. not at the individual participant level), along with further information about each data field (for example, background information about how measures were taken). Genetic variation can be viewed using the MCPS online Variant Browser.

Baseline data (1998-2004)

Available for 159,517 participants

Month and year of recruitment

Socio-demographic

  • Age
  • Sex
  • Area of residence
  • Marital status
  • Educational achievement
  • Occupation
  • Income
  • Health service provider
  • Social development Index (SDI)

Lifestyle characteristics

  • Smoking
  • Passive smoking
  • Alcohol consumption
  • Physical activity
  • Sleep duration
  • Fruit/vegetable intake
  • Fried food intake
  • Type of cooking oil used

Prior diseases and medication

Reproductive history (women)

  • Menopausal status
  • Hysterectomy
  • Oophorectomy
  • Hormone replacement therapy
  • Contraceptive use
  • Age at first sexual relationship
  • Age at first pregnancy
  • Number of pregnancies

Physical measurements

  • Height
  • Weight
  • Waist circumference
  • Hip circumference
  • Systolic blood pressure
  • Diastolic blood pressure

Blood samples

  • Time of blood sampling
  • Time since last meal
  • Glycosylated haemoglobin

Resurvey data (2015-2019)

 Available for 10,143 participants. Similar data to that collected at baseline plus:

Additional questionnaire data

  • Diabetes control questions
  • Diabetes consequences
  • (eg, eyes, amputations, dialysis)
  • Fractures/fall
  • Treatment for breast cancer
  • Additional dietary questions
  • (eg, sugary drinks, added salt,
  • meat, fish, desserts, diets)
  • Cognitive function (MMSE)

Additional samples

  • Time of urine sampling
  • Urinary creatinine
  • Urinary albumin

Additional measurements

  • Bioimpedance (fat mass, fat free mass, muscle mass, muscle score, bone mass, body water, degree of obesity, visceral fat rating, basal metabolic rate, metabolic age, Rohrer’s index)
  • Pulse rate

Baseline NMR metabolomic data using the Nightingale Health platform

First release: 40,297 participants

14 Lipoprotein subclasses

  • XXL VLDL
  • XL VLDL
  • L VLDL
  • M VLDL
  • S VLDL
  • XS VLDL
  • IDL
  • L LDL
  • M LDL
  • S LDL
  • XL HDL
  • L HDL
  • M HDL
  • S HDL

Lipoprotein mean particle sizes and apolipoproteins

  • VLDL-D
  • LDL-D
  • HDL-D
  • Apo A1
  • Apo B

Cholines and glycolysis-related

  • Total cholines
  • Lactate
  • Phosphatidylcholine
  • Citrate
  • Sphingomyelin
  • Glucose

7 Lipid measures for each subclass

  • Particle number
  • Cholesterol
  • Free cholesterol
  • Esterified cholesterol
  • Triglycerides
  • Phosphorolipids
  • Total lipids

Fatty acids

  • Polyunsaturated fatty acids
  • Monounsaturated fatty acids
  • Saturated fatty acids
  • Docosahexaenoic acid
  • Linoleic acid
  • Omega-3
  • Omega-6
  • Total fatty acids

Amino acids

  • Alanine Leucine
  • Glutamine
  • Histidine
  • Isoleucine
  • Valine
  • Phenylalanine
  • Tyrosine

Ketone bodies, inflammation and kidney function

  • Acetate
  • Acetone
  • β-hydroxy-butyrate
  • Albumin
  • Creatinine
  • Glycoprotein acetyls

Genomic Data

Described fully in Ziyatdinov et al. 2023

Genome–wide genotyping with the Illumina Global Screening Array (GSA) version 2

• Non-filtered dataset (140,831 participants)
650,381 variants: 619,501 autosomal variants; 30,101 sex chromosome variants; 779 mitochondrial variants.

• Quality controlled dataset (138,511 participants)
559,923 variants: 539,315 autosomal variants; 19,954 sex chromosome variants; 654 mitochondrial variants.

Whole Exome Sequencing (WES)

• Non-filtered dataset (141,046 participants)
13,331,228 variants: 12,957,291 autosomal variants; 368,300 chromosome X variants; 5,637 chromosome Y variants

Whole Genome Sequencing (WGS)

• Non-filtered dataset (9950 participants)
158,464,363 variants:151,639,445 autosomal variants; 6,342,270 chromosome X variants; 482,648 chromosome Y variants.

• Phased WGS Imputation Reference Panel (MCPS10k)9,948 whole genome sequenced phased samples

• Total of 134,337,444 variants distributed across 22 autosomes and chromosome X

• Data available in four file formats.

TopMed Imputed

• Non-filtered dataset (140,831 participants)
307,624,124 variants: 292,293,083 autosomal variants; 15,331,041 chromosome X variants.

Mortality data (up to 30th September 2022)

  • Date of death
  • ICD-10 underlying cause
  • ICD-10 contributory causes
  • Timing/duration of diseases
  • Location of death
  • Seen by doctor before death

Apo A1=apolipoprotein A1; Apo B=apolipoprotein B; HDL=high density lipoproteins; HDL−D=high density lipoprotein particle diameter; IDL=intermediate density lipoproteins; L=large; LDL=low density lipoproteins; LDL−D=low density lipoprotein particle diameter; M=medium; S=small; VLDL=very low density lipoproteins; VLDL−D=very low density lipoprotein particle diameter; XL=very large; XS=very small; XXL=extremely large.

Additional data currently available only to researchers in Mexico

NMR metabolomic data using the Nightingale Health platform

Second release: 152,833 participants at baseline and 9657 participants at resurvey

All metabolites as listed for the first release plus Aceto-acetate, Clinical LDL-C, and, Glycine and Pyruvate.

About MCPS