The ISIS-1 to ISIS-4 series of trials randomised ~140,000 patients worldwide between 1985 and 1993. These trials were designed to reliably assess the effects of widely usable treatments on survival following a heart attack.
ISIS-1
A randomised trial of intravenous atenolol among 16027 cases of suspected acute myocardial infarction. Patients were randomised between mid 1981 and January 1985.
ISIS-2
A randomised trial of intravenous streptokinase, oral aspirin, both or neither among 17187 cases of suspected acute myocardial infarction. Patients were randomised between March 1985 and December 1987.
ISIS-3
A randomised comparison of streptokinase vs tissue plasminogen activator vs anistreplase and of aspirin plus heparin vs aspirin alone among 41299 cases of suspected acute myocardial infarction. Patients were randomised between September 1989 and January 1991.
ISIS Study of Possible Causes of Heart Attacks
A case-control study added to the ISIS-3 trial to investigate the causes of heart attacks.
ISIS-4
A randomised factorial trial assessing early oral captopril, oral mononitrate, and intravenous magnesium sulphate in 58050 patients with suspected acute myocardial infarction. Patients were randomised between July 1991 and August 1993.
Our team
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Rory Collins
Head of Oxford Population Health and BHF Professor of Medicine and Epidemiology
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Richard Peto
Emeritus Professor of Medical Statistics and Epidemiology
