This article about currently available antiplatelet drugs is part of the Antithrombotic and Thrombolytic Therapy: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition). It describes the mechanism of action, pharmacokinetics, and pharmacodynamics of aspirin, reversible cyclooxygenase inhibitors, thienopyridines, and integrin alphaIIbbeta3 receptor antagonists. The relationships among dose, efficacy, and safety are thoroughly discussed, with a mechanistic overview of randomized clinical trials. The article does not provide specific management recommendations; however, it does highlight important practical aspects related to antiplatelet therapy, including the optimal dose of aspirin, the variable balance of benefits and hazards in different clinical settings, and the issue of interindividual variability in response to antiplatelet drugs.

Original publication

DOI

10.1378/chest.08-0672

Type

Journal article

Journal

Chest

Publication Date

06/2008

Volume

133

Pages

199S - 233S

Keywords

Aspirin, Cyclooxygenase Inhibitors, Evidence-Based Medicine, Humans, Platelet Aggregation Inhibitors, Platelet Glycoprotein GPIIb-IIIa Complex, Pyridines