A total of 277 patients with apparently localised prostatic cancer (T2-T4 NXMO) were allocated at random to receive radiotherapy alone (88), orchiectomy alone (90) and combined therapy (99) between 1980 and 1985. The main outcome measures were survival, time to appearance of metastases and treatment of local disease progression by further transurethral resection. Orchiectomy, whether alone or with radiotherapy, produced a significant delay in detection of metastases when compared with radiotherapy alone. There were no statistically significant differences between the 3 treatment groups in local disease control or in overall survival.

Type

Journal article

Journal

Br J Urol

Publication Date

09/1992

Volume

70

Pages

304 - 309

Keywords

Combined Modality Therapy, Humans, Male, Orchiectomy, Prostate, Prostatic Neoplasms, Radiotherapy, Risk Factors