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For most older women with early breast cancer, standard treatment after breast-conserving surgery is whole-breast radiotherapy and endocrine treatment. Numerous randomised trials have confirmed that radiotherapy after breast conservation reduces the rate of local recurrence substantially and may have a small long-term (15-year) benefit on survival on meta-analysis of these trials. 1 The PRIME II trial aimed to assess the effect of omission of radiotherapy on local control in older women at low risk of local recurrence.

Original publication





Book title

50 Landmark Papers: Every Breast Surgeon Should Know

Publication Date



217 - 220