Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

Although studies have shown that cigarette smoking and elevated serum cholesterol and blood pressure levels are the greatest risk factors for coronary heart disease (CHD), it has been suggested that they account for only 50% of cases. The relationship between these risk factors and CHD, however, is often underestimated because of "regression dilution bias." Using data from the British Regional Heart Study, we estimated the population-attributable risk fraction for these risk factors after adjusting for regression dilution bias and found that they account for at least 75% of major CHD events in middle-aged men.


Journal article


Cardiology Review

Publication Date