Genotyping and population characteristics of the China Kadoorie Biobank.
Walters RG., Millwood IY., Lin K., Schmidt Valle D., McDonnell P., Hacker A., Avery D., Edris A., Fry H., Cai N., Kretzschmar WW., Ansari MA., Lyons PA., Collins R., Donnelly P., Hill M., Peto R., Shen H., Jin X., Nie C., Xu X., Guo Y., Yu C., Lv J., Clarke RJ., Li L., Chen Z., China Kadoorie Biobank Collaborative Group None.
The China Kadoorie Biobank (CKB) is a population-based prospective cohort of >512,000 adults recruited from 2004 to 2008 from 10 geographically diverse regions across China. Detailed data from questionnaires and physical measurements were collected at baseline, with additional measurements at three resurveys involving ∼5% of surviving participants. Analyses of genome-wide genotyping, for >100,000 participants using custom-designed Axiom arrays, reveal extensive relatedness, recent consanguinity, and signatures reflecting large-scale population movements from recent Chinese history. Systematic genome-wide association studies of incident disease, captured through electronic linkage to death and disease registries and to the national health insurance system, replicate established disease loci and identify 14 novel disease associations. Together with studies of candidate drug targets and disease risk factors and contributions to international genetics consortia, these demonstrate the breadth, depth, and quality of the CKB data. Ongoing high-throughput omics assays of collected biosamples and planned whole-genome sequencing will further enhance the scientific value of this biobank.