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OBJECTIVE: Liver fat associates with obesity-related metabolic disturbances and may precede incident diseases. Metabolomic profiles of liver fat in the UK Biobank were investigated. METHODS: Regression models assessed the associations between 180 metabolites and proton density liver fat fraction (PDFF) measured 5 years later through magnetic resonance imaging, as the difference (in SD units) of each log metabolite measure with 1-SD higher PDFF among those without chronic disease and not taking statins, and by diabetes and cardiovascular diseases. RESULTS: After accounting for confounders, multiple metabolites were associated positively with liver fat (p 

Original publication




Journal article


Obesity (Silver Spring)

Publication Date





1121 - 1132


Humans, Cardiovascular Diseases, Biological Specimen Banks, Magnetic Resonance Imaging, Liver, Non-alcoholic Fatty Liver Disease, Triglycerides, Lipoproteins, HDL, United Kingdom, Lipoproteins, LDL