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OBJECTIVES: This meta-analysis examines whether there is any advantage of coronary artery bypass graft with bilateral internal thoracic artery (BITA) as an in situ versus composite graft. METHODS: We searched MEDLINE and EMBASE Databases from 1996 to 2016 for studies that compared coronary artery bypass graft with BITA as in situ versus composite graft. Data were extracted by 2 independent investigators and meta-analyzed with the use of random effects. RESULTS: Two randomized controlled trials (RCTs; n = 705), 2 matched (n = 1688), and 4 unadjusted observational studies (n = 3517) met inclusion criteria. Composite grafting trended towards greater distal anastomoses (+0.22, 95% confidence interval, -0.01 to +0.45 anastomoses/patient; P = .06 [4 unadjusted observational studies]) and greater distal anastomoses using an internal thoracic artery (+0.80, 95% confidence interval, 0.41-1.18 anastomoses/patient; P 

Original publication




Journal article


J Thorac Cardiovasc Surg

Publication Date





1108 - 1116.e16


bilateral internal thoracic artery, coronary artery bypass graft, graft patency, Aged, Coronary Artery Bypass, Coronary Artery Disease, Coronary Vessels, Female, Humans, Internal Mammary-Coronary Artery Anastomosis, Male, Middle Aged, Postoperative Complications, Risk Assessment, Risk Factors, Treatment Outcome, Vascular Patency