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OBJECTIVE: The success of open and endovascular repair of abdominal aortic aneurysms (AAA) is hampered by postoperative dilatation of the anatomical neck of the AAA, which is used for graft attachment. The purpose of this study was to determine whether the macroscopically non-diseased infrarenal aortic neck of AAA is histologically and biochemically altered at the time of operative repair. METHODS: We harvested full-thickness aortic wall samples as longitudinal stripes spanning from AAA neck to aneurysmal sac in 22 consecutive patients undergoing open surgical AAA repair. Control tissue was obtained from five organ donors and five deceased subjects undergoing autopsy without evidence of aneurysmal disease. We assessed aortic media thickness, number of intact elastic lamellar units, media destruction, and neovascularization grade and performed immunohistochemistry for matrix metalloproteinase (MMP)-9 and phosphorylated c-Jun N-terminal kinase (p-JNK). MMP-9 and p-JNK protein expressions were quantified using Western Blots. RESULTS: The median thickness of the aortic media was 1150 mum in control tissue (range, 1000-1300), 510 mum in aortic necks (250-900), and 200 mum in aortic sacs (50-500, P from nonparametric test for trend

Original publication




Journal article


J Vasc Surg

Publication Date





425 - 434


Aged, Aged, 80 and over, Aortic Aneurysm, Abdominal, Biomarkers, Case-Control Studies, Female, Humans, Immunohistochemistry, JNK Mitogen-Activated Protein Kinases, Laparotomy, Male, Matrix Metalloproteinase 9, Middle Aged, Postoperative Complications, Reference Values, Reverse Transcriptase Polymerase Chain Reaction, Sensitivity and Specificity, Severity of Illness Index, Tissue Culture Techniques, Tunica Intima, Vascular Surgical Procedures