Evidence for molecular differences in prostate cancer between african American and Caucasian Men
Khani F., Mosquera JM., Park K., Blattner M., O'Reilly C., MacDonald TY., Chen Z., Srivastava A., Tewari AK., Barbieri CE., Rubin MA., Robinson BD.
Experimental design: Dominant tumor nodules from radical prostatectomy specimens of 105 African American men (AAM) were compared with 113 dominant nodules from Caucasianmen (CaM). Clinical and pathologic characteristics of the two groups were similar. SPINK1 overexpression was evaluated by immunohistochemistry, ERG rearrangement and PTEN deletion by FISH, and SPOP mutation by Sanger sequencing.