The association between age of alcohol onset with type 2 diabetes: a 0.5 million cohort study in china.
Li H., Lv J., Yu C., Guo Y., Bian Z., Fan J., Yang L., Chen Y., Du H., Long H., Zhang Z., Chen J., Chen Z., Huang T., Li L., Collaborative Group OBOTCKB.
It is well known that alcohol consumption is associated with type 2 diabetes. However, the association between age of alcohol onset (AAO) and drinking duration with type 2 diabetes among Chinese adults is not fully understood. Our study was based on the data from the China Kadoorie Biobank, which included 512,712 participants aged 30-79 years in China from 2004-2008. Cox proportional-hazard model was used to estimate the association between AAO and drinking duration with type 2 diabetes. After adjustment for potential covariates, 18.1 ≤ AAO ≤ 29.0, 29.1 ≤ AAO ≤ 39.0 and AAO > 39.0 were associated with 22% (95%CI: 14%, 30%), 25% (95%CI: 17%, 33%) and 32% (95%CI: 24%, 39%) lower hazard ratio of type 2 diabetes, compared with abstainer, respectively. Drinking duration < 10.1, 10.1 ≤ duration ≤ 20.0, and 20.1 ≤ duration ≤ 30.0 were associated with a lower risk of type 2 diabetes, compared with abstainer. Among weekly drinkers, AAO < 18.1 and drinking duration>30.0 were associated with 18% (95%CI: 9%, 33%) and 20% (95%CI: 3%, 40%) higher hazard ratio of type 2 diabetes, compared with 18.1 ≤ AAO ≤ 29.0 and drinking duration < 10.1, respectively. In conclusion, a decrease risk of type 2 diabetes was associated with a late AAO and a short drinking duration in the largest prospective cohort of Chinese adults. But early AAO and long drinking duration was not associated with lower risk of type 2 diabetes.