Dr Michael Holmes
|Tel||+44 (0)1865 743644|
BSc(Hons) MBBS MSc(Epidemiology) PhD MRCP
Senior Clinical Research Fellow in Cardiovascular Medicine
- Clinical Trial Service Unit and Epidemiological Studies Unit
Michael Holmes studied Medicine at University of St Andrews and University College London, graduating in 2005. Working in the NHS as a hospital physician, he held NIHR clinical academic posts including academic foundation year and an academic clinical fellowship in Clinical Pharmacology and Therapeutics/General Internal Medicine. Michael then undertook a Masters in Epidemiology at London School of Hygiene and Tropical Medicine and completed a PhD in Genetic Epidemiology at University College London. Following his PhD, he was Assistant Professor at University of Pennsylvania, Philadelphia, USA, where he investigated genetic determinants of clinical outcomes following organ transplantation.
Michael is a Senior Clinical Research Fellow in Cardiovascular Medicine at CTSU. He is working within the China Kadoorie Biobank (CKB) to investigate causal risk factors underpinning cardiovascular disease and cancer subtypes. Michael's expertise lies in using genetic variants to disentangle causality from confounding with the aim of improving understanding of disease aetiology and identifying novel therapeutic targets for disease prevention.
Genetic variants associated with type 2 diabetes and adiposity and risk of intracranial and abdominal aortic aneurysms.
van 't Hof FN. et al, (2017), Eur J Hum Genet
Cannabis use and risk of schizophrenia: a Mendelian randomization study.
Vaucher J. et al, (2017), Mol Psychiatry
Association between diabetes and cause-specific mortality in rural and urban China
Bragg F. et al, (2017), JAMA
Diabetes, plasma glucose and incidence of pancreatic cancer: A prospective study of 0.5 million Chinese adults and a meta-analysis of 22 cohort studies.
Pang Y. et al, (2017), Int J Cancer
Commentary: Mendelian randomization-inspired causal inference in the absence of genetic data.
Zuccolo L. and Holmes MV., (2016), Int J Epidemiol