Dr Michael Holmes
|Tel||+44 (0)1865 743644|
BSc(Hons) MBBS MSc(Epidemiology) PhD MRCP
Senior Clinical Research Fellow in Cardiovascular Medicine
- Clinical Trial Service Unit and Epidemiological Studies Unit
Michael Holmes studied Medicine at University of St Andrews and University College London, graduating in 2005. Working in the NHS as a hospital physician, he held NIHR clinical academic posts including academic foundation year and an academic clinical fellowship in Clinical Pharmacology and Therapeutics/General Internal Medicine. Michael then undertook a Masters in Epidemiology at London School of Hygiene and Tropical Medicine and completed a PhD in Genetic Epidemiology at University College London. Following his PhD, he was Assistant Professor at University of Pennsylvania, Philadelphia, USA, where he investigated genetic determinants of clinical outcomes following organ transplantation.
Michael is a Senior Clinical Research Fellow in Cardiovascular Medicine at CTSU. He is working within the China Kadoorie Biobank (CKB) to investigate causal risk factors underpinning cardiovascular disease and cancer subtypes. Michael's expertise lies in using genetic variants to disentangle causality from confounding with the aim of improving understanding of disease aetiology and identifying novel therapeutic targets for disease prevention.
Mendelian randomization in cardiometabolic disease: challenges in evaluating causality.
Holmes MV. et al, (2017), Nat Rev Cardiol, 14, 577 - 590
Genetic and epigenetic studies of adiposity and cardiometabolic disease.
Holmes MV. et al, (2017), Genome Med, 9
Education and coronary heart disease: mendelian randomisation study.
Tillmann T. et al, (2017), BMJ, 358
Association of Body Mass Index With Cardiometabolic Disease in the UK Biobank: A Mendelian Randomization Study.
Lyall DM. et al, (2017), JAMA Cardiol, 2, 882 - 889
Relations between lipoprotein(a) concentrations, LPA genetic variants, and the risk of mortality in patients with established coronary heart disease: a molecular and genetic association study.
Zewinger S. et al, (2017), Lancet Diabetes Endocrinol, 5, 534 - 543