Associate Professor Michael Holmes
BSc(Hons) MBBS MSc(Epidemiology) PhD MRCP
- Clinical Trial Service Unit and Epidemiological Studies Unit
Michael Holmes studied Medicine at University of St Andrews and University College London, graduating in 2005. Working in the NHS as a hospital physician, he held NIHR clinical academic posts including academic foundation year and an academic clinical fellowship in Clinical Pharmacology and Therapeutics/General Internal Medicine. Michael then undertook a Masters in Epidemiology at London School of Hygiene and Tropical Medicine and completed a PhD in Genetic Epidemiology at University College London. Following his PhD, he was Assistant Professor at University of Pennsylvania, Philadelphia, USA, where he investigated genetic determinants of clinical outcomes following organ transplantation.
Michael is a Senior Clinical Research Fellow in Cardiovascular Medicine at CTSU. He is working within the China Kadoorie Biobank (CKB) to investigate causal risk factors underpinning cardiovascular disease and cancer subtypes. Michael's expertise lies in using genetic variants to disentangle causality from confounding with the aim of improving understanding of disease aetiology and identifying novel therapeutic targets for disease prevention.
Adiposity, circulation protein biomarkers and risk of major vascular diseases
Pang Y. et al, (2020), JAMA Cardiology
Genome-wide Study Identifies Association between HLA-B∗55:01 and Self-Reported Penicillin Allergy.
Krebs K. et al, (2020), Am J Hum Genet, 107, 612 - 621
Genomic and drug target evaluation of 90 cardiovascular proteins in 30,931 individuals.
Folkersen L. et al, (2020), Nat Metab, 2, 1135 - 1148
Observational and Genetic Associations of Body Mass Index and Hepatobiliary Diseases in a Relatively Lean Chinese Population.
Pang Y. et al, (2020), JAMA Netw Open, 3
Phenome-wide Mendelian randomization mapping the influence of the plasma proteome on complex diseases.
Zheng J. et al, (2020), Nat Genet, 52, 1122 - 1131