Genetic substructure in Latin American individuals reveals novel associations, mechanistic insights, and variable polygenic risk score transferability for alcohol traits

Montalvo-Ortiz J., Martínez-Magaña J., Brito DA., Trichia E., Rivera-Hernández M., Porras L., Sullivan K., Jacobson D., Kember R., Nuñez D., Torres J., Peterson R., Zhou H., Vlot A., Merlet J., Townsend A., Wells A., Alvarez C., Lane M., Alegre-Díaz J., Berumen J., Kuri-Morales P., Tapia-Conyer R., Emberson J., Kranzler H., Justice A., Gelernter J., Sanchez-Roige S., Wassertheil-Smoller S., Perreira K., Daviglus M., Nicolini H., Genis-Mendoza A., Villatoro-Velazquez J., Medina-Mora M., Bustos-Gamiño M., Belangero S., Santoro M., Rohde L., Bressan R., Miguel E., Pan P., Salum G., Tucker K., Ordovas J., Coletta D., Parra O., Klimentidis Y., Mandarino L., Moysés-Oliveira M., Tempaku P., Andersen M., Tufik S., Lancaster E., Singh M., Tusié-Luna M., Aguilar-Salinas C., Ochoa-Guzmán A., Pereira A., Martinez-Gonzalez K., Bulik C., Group SFSW., Consortium LAG., Atkinson E., Giusti-Rodríguez P.

DOI

10.21203/rs.3.rs-8789707/v1

Type

Preprint

Publication Date

2026-02-27T00:00:00+00:00

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