Over 300 million adults are obese, but little is known about the impact of obesity on cardiovascular health. We discuss recent genetic and epigenetic studies of adiposity that indicate a causal role for general and central adiposity in cardiometabolic disease, and highlight potential mechanisms including insulin resistance and gene expression.

Original publication

DOI

10.1186/s13073-017-0474-5

Type

Journal article

Journal

Genome Med

Publication Date

18/09/2017

Volume

9

Keywords

Adiposity, Cardiovascular Diseases, Epigenomics, Humans, Insulin Resistance