Statins are widely used lipid-lowering drugs that are effective in reducing cardiovascular disease risk. Although they are generally well tolerated, they can cause muscle toxicity, which can lead to severe rhabdomyolysis. Research in this area has been hampered to some extent by the lack of standardized nomenclature and phenotypic definitions. We have used numerical and descriptive classifications and developed an algorithm to define statin-related myotoxicity phenotypes, including myalgia, myopathy, rhabdomyolysis, and necrotizing autoimmune myopathy.

Original publication

DOI

10.1038/clpt.2014.121

Type

Journal article

Journal

Clin Pharmacol Ther

Publication Date

10/2014

Volume

96

Pages

470 - 476

Keywords

Autoimmune Diseases, Humans, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Muscular Diseases, Myalgia, Myositis, Phenotype, Rhabdomyolysis, Risk Factors, Terminology as Topic, Time Factors