The Application of Genetic Risk Scores in Age-Related Macular Degeneration: A Review
Cooke Bailey JN., Hoffman JD., Sardell RJ., Scott WK., Pericak-Vance MA., Haines JL.
Age-related macular degeneration (AMD), a highly prevalent and impactful disease of aging, is inarguably influenced by complex interactions between genetic and environmental factors. Various risk scores have been tested that assess measurable genetic and environmental contributions to disease. We herein summarize and review the ability and utility of these numerous models for prediction of AMD and suggest additional risk factors to be incorporated into clinically useful predictive models of AMD.