Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival: an overview of the randomised trials

Introduction

This web site contains extended sets of figures for the 2005 "systemic therapy" paper published in The Lancet 2005; 365: 1687-1717.

The Contents List below provides hyperlinks to four sections: the paper itself; the figures and tables presented in the paper ("publication version"); an enhanced version of the figures presented in the paper; and a substantially expanded set of the same figures together with additional figures illustrating the detail of the tables.

The format of Annex-Figures 1-14 resembles that of the corresponding Text-Figures 1-14; but the Annexes to the Tables each consist of several very detailed Figures. Appendix to Table 1 gives "forest plots" of trial-specific data and rate ratios, with one line per trial, for some 200 different trials. Appendix to Table 2 (side-effects of polychemotherapy) and Appendix to Table 3 (side-effects of about five years of tamoxifen) give detailed "forest plots", with one line per trial, for the incidence of second cancers (e.g. contralateral breast, endometrium etc) and for mortality from particular causes (e.g. stroke, thromboembolism etc).

In addition, there are (slow-loading) sets of reduced-size illustrations which show the entire set in miniature, again hyperlinked to the individual figures, and also Adobe Acrobat ® (PDF) files of the illustrations.

Editors' Note: Various improvements to the web site are planned. In case of difficulty fitting figures onto the page, adjustments to page margins and font size might be necessary; some should be printed in 'landscape' mode. In particular, if using Microsoft Internet Explorer ® we recommend using "Medium" Text Size (View menu) or, if using Netscape Navigator ®, Mozilla ® or Firefox ®, Font Size 12 (Edit - Preferences... Appearance - Fonts menu). "Super-size" versions of all figures are included so that fine detail can be seen clearly on the computer screen, although it is the "normal" versions which should be printed.
 

Christina Davies and Jon Godwin, Oxford
E-Mail: christina.davies@ctsu.ox.ac.uk and jon.godwin@ctsu.ox.ac.uk

Contents List

• The Lancet paper:
• Early Breast Cancer Trialists' Collaborative Group. Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival: an overview of the randomised trials. The Lancet 2005; 365: 1687-1717. (n.b. an on-line subscription is required)
• Final typescript of the paper (free to view; 1460 kb) in Adobe Acrobat ® format
• The Lancet Press Release in Adobe Acrobat ® format
  
  You may need to download the Adobe Reader to view the PDF files; Version 5 or later is required.

 
• Quick-loading indexes, hyperlinked to the items listed, of:
• Publication version of Figures 1-14 and Tables 1-4
• Enhanced version of Figures 1-14 and Tables 1-4
• Annex-Figures 1-14
• Appendix to Table 1
• Appendix to Table 2
• Appendix to Table 3
• Appendix to Table 4

 
• Sets of reduced-size illustrations (which will take some time to load over a slow connexion), hyperlinked to the items shown, of:
• Publication version of Figures 1-14 and Tables 1-4
• Enhanced version of Figures 1-14 and Tables 1-4
• Annex-Figures 1-14
• Appendix to Table 1
• Appendix to Table 2
• Appendix to Table 3
• Appendix to Table 4

 
• Adobe Acrobat ® (PDF) files of illustrations (which will take some time to load over a slow connexion) of:
• Publication version of Figures 1-14 (345 kb)
• Enhanced version of Figures 1-14 (487 kb)
• Annex-Figures 1-14 (942 kb)
• Appendix to Table 1 (845 kb)
• Appendix to Table 2 (368 kb)
• Appendix to Table 3 (281 kb)
• Appendix to Table 4 (70 kb)


You may need to download the Adobe Reader to view the PDF files; Version 5 or later is required.

• Master list of all trials in the EBCTCG 2000 overview database (710 kb HTML file). Trials appearing in "forest plots" each have a year code, e.g. 77J1, which can be used to find the corresponding details in the master list.

[End of document, updated to 14 November 2005, slightly amended 25 May 2011]