Publications in 2010
Publications in 2009
Publications in 2008
Publications in 2007
Publications in 2006
Publications in 2005
Publications in 2004
Publications in 2003
Publications in 2002
Publications in 2001
Publications in 2000
Publications in 1999
Publications in 1998
Publications in 1997
Publications in 1996
Publications in 1995

Publications in 2010

Brown J, Robb Y, Lowndes A, Duffy K, Tolson D, Godwin J. The PLACE Project: development of a toolkit to profile learning achievements in in-patient settings from the perspectives of older people, family carers, nurses, support workers and student nurses. Report, NHS Education Scotland, NHS Quality Improvement Scotland 2010.

MacGilchrist C, Paul L, Ellis BM, Howe TE, Kennon B, Godwin J. Lower limb risk factors for falls in people with diabetes mellitus. Diab Med 2010; 27: 162-168.

Watson H, Munro A, Wilson M, Kerr S, Godwin J. The involvement of nurses and midwives in screening and brief interventions for hazardous and harmful use of alcohol and psychoactive substances. WHO 2010; WHO/HRH/HPN/10-6.

Publications in 2009

Antithrombotic Trialists' (ATT) Collaboration. (Writing Committee: Baigent C, Blackwell L, Buring J, Collins R, Emberson J, Godwin J, Hennekens C, Kearney P, Meade T, Patrono C, Peto R, Roncaglioni MC, Zanchetti A.) Aspirin in the primary prevention of vascular disease: collaborative meta-analysis of 6 primary and 16 secondary prevention trials among 95,000 and 17,000 individuals. Lancet 2009 May 30; 373(9678): 1849-60

Armitage J, Bowman L. Low-density lipoprotein cholesterol as a therapeutic target. In: Tonkin A (editor). Therapeutic Strategies in Lipid Disorders.

Aromatase Inhibitor Overview Group (writing committee: Dowsett M, Cuzick J, Ingle J, Coates A, Forbes J, Bliss J, Buyse M, Baum M, Buzdar A, Mouridsen H, Colleoni M, Coombes C, Snowdon C, Gnant M, Jakesz R, Kaufmann M, Boccardo F, Godwin J, Davies C, Peto R). Meta-analysis of breast cancer outcomes in adjuvant trials of aromatase inhibitors versus tamoxifen. J Clin Oncol 2009 (submitted)

Baigent C, Peto R, Gray R, Parish S, Collins R. Large-scale randomised evidence: trials and meta-analyses of trials. In: Warrell DA et al (eds), Oxford Textbook of Medicine, 5th edition, 2008. (in press)

Baigent C, Blackwell L, Buring JE, Collins RE, Emberson JR, Godwin J, Hennekens CH, Kearney PM, Meade TW, Patrono C, Peto R, Roncaglioni MC, Zanchetti A for the Antithrombotic Trialists' (ATT) Collaboration. Aspirin in the primary prevention of vascular disease: collaborative meta-analysis of individual patient data from 6 primary trials among 95,000 individuals. Lancet (submitted)

Batty GD, Kivimaki M, Morrison D, Huxley R, Smith GD, Clarke R, Marmot M G, Shipley MJ. Risk factors for prostatic cancer mortality. Null associations in the original Whitehall study. Cancer epidemiology, biomarkers and prevention 2009 (in Press).

Bhala N, Bhopal R, Brock A, Griffiths C, Wild S. Alcohol-related and hepatocellular cancer deaths by country of birth in England and Wales: analysis of mortality and census data. J Public Health (Oxf), 2009 Jun; 31(2):250-7

Boffetta et al. Alcohol poisoning is a main determinant of recent mortality trends in Russia : evidence from a detailed analysis of mortality statistics and autopsies. NEJM 2008 (submitted).

Calvert J, Dutton G, Macintryre-beon C, Godwin J. Assessment of dorsal stream dysfunction using a clinical history taking protocol. Child Vision Research Society Conference, Cardiff 2009 (abstract). Childhood Acute Lymphoblastic Leukaemia Collaborative Group (CALLCG). Beneficial and harmful effects of anthracyclines in the treatment of childhood acute lymphoblastic leukaemia: a systematic review and meta-analysis. Br J Haematol, 2009 May; 145(3):376-88

Clarke R. Brain. In Stanner S (Editor), Diet, Nutrition and Ageing. British Nutritional Foundation, London . Blackwell Scientific Publications 2009.

Emberson JR, Baigent C. Clinical Trials and meta-analysis. In: Yusuf S (ed). Evidence-based cardiology. BMJ Publications, London , 2008 (in press).

Gray A, Read S, McGale P, Darby S. Lung cancer deaths from indoor radon and the cost effectiveness and potential of policies to reduce them. BMJ (in press)

Haynes R, Landray MJ, Winearls CG. Reassuring results with regard to the effect of donor nephrectomy on cardiovascular outcomes. Nat Clin Pract Nephrol. 2009 Mar;5(3):126-7

Heart Protection Study Collaborative Group (writing committee: Mihaylova B, Briggs A, Hlatky M, Armitage J, Parish S, Gray A, Collins R). Statin cost-effectiveness in the United States for people at different vascular risk levels. Circulation 2008 (accepted for publication).

Heart Protection Study Collaborative Group. (Writing Committee: Armitage J, Bowman L, Collins R, Parish S and Tobert J) Effects of simvastatin 40mg daily on muscle and liver adverse effects in a 5-year randomized placebo-controlled trial in 20,536 high-risk people. BMC Clin Pharmacol 2009 Mar 31;9:6

Kathiresan S, Willer CJ, Peloso GM, Demissie S, Musunuru K, Schadt EE, Kaplan L, Bennett D, Li Y, Tanaka T, Voight BF, Bonnycastle LL, Jackson AU, Crawford G, Surti A, Guiducci C, Burtt NP, Parish S, Clarke R, Zelenika D, Kubalanza KA, Morken MA, Scott LJ, Stringham HM, Galan P, Swift AJ, Kuusisto J, Bergman RN, Sundvall J, Laakso M, Ferrucci L, Scheet P, Sanna S, Uda M, Yang Q, Lunetta KL, Dupuis J, de Bakker PI, O'Donnell CJ, Chambers JC, Kooner JS, Hercberg S, Meneton P, Lakatta EG, Scuteri A, Schlessinger D, Tuomilehto J, Collins FS, Groop L, Altshuler D, Collins R, Lathrop GM, Melander O, Salomaa V, Peltonen L, Orho-Melander M, Ordovas JM, Boehnke M, Abecasis GR, Mohlke KL, Cupples LA. Common variants at 30 loci contribute to polygenic dyslipidemia. Nat Genet. 2009 Jan;41(1):56-65

Kuri-Morales P, Emberson J, Alegre-Diaz J, Tapia-Conyer R, Collins R, Peto R, Whitlock G. The prevalence of chronic diseases and major disease risk factors at different ages among 150 000 men and women living in Mexico City : cross-sectional analyses of a prospective study. BMC Public Health 2009; 9: 9 (doi.10.1186/1471-2458-9-9

Mozaffarian D, Clarke R. Quantitative effects on cardiovascular risk factors and coronary heart disease risk of replacing partially hydrogenated vegetable oils with other fats and oils. Eur J Clin Nutr 2009 (in press).

Newhouse S, Farral M, Wallace C, Hoti M, Burke B, Howard P, Onipinla A, Lee K, Shaw-Hawkins S, Dobson R, Farrall M, Brown M, Samani NJ, Dominiczak AF, Connell JM, Webster J, Lathrop GM, Kooner J, Chambers J, Elliott P, Clarke R, Collins R, Laan M, Org E, Juhanson P, Veldre G, Viigimaa M, Eyheramendy S, Cappuccio FP, Ji C, Iacone R, Strazzullo P, Kumari M, Marmot M, Brunner E, Caulfield M, Munroe PB. Polymorphisms in the WNK1 gene are significantly associated with blood pressure variation and urinary potassium excretion. PLoS ONE. 2009;4(4):e5003. Epub 2009 Apr 4

Parish S, Peto R, Palmer A, Clarke R, Lewington S, Offer A, Whitlock G, Clark S, Youngman L, Sleight P, Collins R for the International Studies of Infarct Survival (ISIS) collaborators. The joint effects of apolipoprotein B, apolipoprotein A1, LDL cholesterol and HDL cholesterol on risk: 3510 cases of acute myocardial infarction and 9805 controls. Eur Heart J 2009 Jun 11

Parkin DM, Bray F. Evaluation of data quality in the cancer registry: principles and methods Part II. Completeness. Eur J Cancer. 2009 Mar;45(5):756-64.

Prospective Studies Collaboration (writing committee: Whitlock G, Lewington S, Sherliker P, Clarke R, Emberson J, Halsey J, Qizilbash N, Collins R, Peto R). Body-mass index and cause-specific mortality in 900,000 adults: collaborative analysis of 57 prospective studies. Lancet 2009 Mar 28;373(9669):1083-96

Rochester L, Baker K, Jones A, Godwin J, Burn D. Does deep brain stimulation of the STN in advanced Parkinson's disease change habitual physical activity? Movement Disorder Society Congress, Paris 2009 (abstract)

Rochester L, Baker K, Jones A, Godwin J, Burn D. Long term follow up of advanced Parkinson's disease following STN deep brain stimulation: impact on gait, balance and functional activity. International Society of Posture and Gait Research Conference, Bologna 2009 (abstract)

Rochester L, Burn DJ, Woods G, Godwin J, Niewboer A. Does auditory rhythmical cueing improve gait in people with Parkinson's disease and cognitive impairment? A feasibility study. Mov Disord 2009; 24: 839-845

Vendhan G, Peto R. Smoking, drinking and incident tuberculosis in rural India : population-based case-control study. Int J Epidemiol 2009 (submitted)

Yang L, Kuper H, Sandin S, Margolis KL, Chen Z, Adami HO, Weiderpass E. Reproductive history, oral contraceptive use, and the risk of ischemic and hemorrhagic stoke in a cohort study of middle-aged Swedish women. Whitlock G, Lewington S, Sherliker P, Clarke R, Emberson J, Halsey J, Qizilbash N, Collins R, Peto R for the Prospective Studies Collaboration. Body mass index and cause-specific mortality in 900,000 adults: collaborative meta-analysis of individual participant data from the 57 prospective studies with 90,000 deaths. Lancet 2009 (in press). Stroke. 2009 Apr;40(4):1050-8

Publications in 2008

Armitage J, Souhami R, Friedman L, Hilbrich L et al. The impact of privacy and confidentiality law on the conduct of clinical trials. Clin Trials 2008; 5(1):70-4.

Armitage J. Commentary on NICE technology appraisal guidance on ezetimibe for the treatment of primary (heterozygous-familial and non-familial) hypercholesterolaemia. Heart. 2008; 94: 643-5.

Arriagada R, Averbeck D, Dahl AA, Darby S, Fosså S, Friberg S, Polgár, de Vathaire F. OECI Workshop on late-side effects of cancer treatments. European Journal of Cancer 2009; 45: 354-359

Awasthi S, Peto R, Pande VK, Fletcher RH, Read S, Bundy DAP. Effects of deworming on malnourished preschool children in India : an open-labelled, cluster-randomized trial. PLoS Negl Trop Dis 2008; 2:e223 (doi:10.1371/journal.pntd.0000223).

Baigent C, Emberson JR. Randomisation is essential for progress in transplant medicine. Transplantation 2008; 86: 1-2.

Baigent C, Harrell FE, Buyse M, Emberson JR, Altman DG. Ensuring trial validity by data quality assurance and diversification of monitoring methods. Clin Trials 2008;5: 49-55.

Baigent C, Patrono C. Selective COX -2 inhibitors: where do we go from here? Lancet 2008; 372: 1712-3.

Baigent C. Cholesterol and lipids. International Encyclopedia of Public Health (First Edition), Volume 1, pp 693-704, London , 2008.

Bennett DA, Xu P, Clarke R, Zondervan K, Parish S, Palmer A, Cardon L, Peto R, Lathrop M, Collins R for the International Study of Infarct Survival (ISIS) Collaborators. The exon 1 -8C/G SNP in the PSMA6 gene contributes only a small amount to the burden of myocardial infarction in 6946 cases and 2720 controls from a United Kingdom (UK) population. Eur J Hum Genet. 2008;16: 480-6.

Booth J, O’Neil K, Lawrence M, McMillan L, Munro A, Godwin J, MacLaren W. Nocturia in older people. Report, Queen’s Nursing Institute Scotland 2008.

Bosetti C, Gallus S, Peto R, Negri E, Talamini R, Tavani A, Franceschi S, La Vecchia C. Smoking, smoking cessation and cumulative risk of upper aero-digestive tract cancers. Am J Epidemiol 2008 Feb 15; 167(4):468-73.

Broadbent HM, Peden JF, Lorkowski S, Goel A. Ongen H, Green F, Clarke R, Collins R, Franzosi MG, Tognoni G, Seedorf U, Rust S, Eriksson P, Hamsten A, Fararall M, Watkins H for the PROCARDIS consortium. Susceptibility to coronary artery disease and diabetes is encoded by distinct, tightly linked, SNPs in the ANRIL locus on chromosome 9p. Hum Mol Genet 2008; 17(6):806-14.

Bulbulia R, Bowman L, Wallendszus K, Parish S, Armitage J, Collins R. Does simvastatin save lives; If so, when and in whom? (Authors' reply). J Vasc Surg; 47: 901.

Cholesterol Treatment Trialists' (CTT) Collaborators (Writing Committee: Kearney PM, Blackwell L, Collins R, Keech A, Simes J, Peto R, Armitage J, Baigent C). Efficacy of cholesterol-lowering therapy in 18,686 people with diabetes in 14 randomised trials of statins: a meta-analysis. Lancet 2008; 371: 117-25.

Clarke R, Emberson JR, Breeze E, Casas JP, Parish S, Hingorani AD, Fletcher A, Collins R, Smeeth L. Biomarkers of inflammation predict both vascular and non-vascular mortality in older men. Eur Heart J. 2008;29: 800-9.

Clarke R, Sherliker P, Hin H, Molloy AM, Nexo E, Ueland PM, Emmens K, Scott JM, Evans JG. Folate and vitamin B12 status in relation to cognitive impairment and anaemia in the setting of voluntary fortification in the UK. Br J Nutr. 2008;100:1054-9.

Clarke R. B-vitamins and prevention of dementia. Proc Nutr Soc. 2008;67(1):75-81.

Clarke R. Cholesterol fractions and heart disease mortality in older men. Cardiology Reviews 2008; 25:34-37.

Clarke RJ, Bennett DA. B vitamins for prevention of cognitive decline: insufficient evidence to justify treatment. JAMA. 2008;300(15):1819-21.

Clarke R, Shipley M, Armitage J, Collins R, Harris W. Plasma phospholipid fatty acids and coronary heart disease in older men: Whitehall study of London Civil Servants. Br J Br J Nutr . 2008 Dec 24:1-6.

Cluett C, Brayne C, Clarke R, Evans G, Matthews F, Rubinsztein DC, Huppert F, Llewellyn DJ, Rice N, Henley W, Frayling TM, Murray A, Melzer D. Polymorphisms in LMNA and near a SERPINA gene cluster are associated with cognitive function in older people. Neurobiol Aging. 2008; 8.

Collaborative Group on Epidemiological Studies of Ovarian Cancer. Ovarian cancer and oral contraceptives: collaborative reanalysis of data from 45 epidemiological studies including 23,257 women with ovarian cancer and 87,303 controls. Lancet 2008; 371(9609):303-14.

Committee of Cancer Control in Low- and Middle-Income Countries (Sloan FA, Clark D, Debas HT, Huerta EE, Jha P, Joranson DE, Kaur R, Mooney KH, Ngoma TA, Parkin DM, Peto R, Rustum YM, Vikram B) Executive Summary. In: Sloan FA, Gelband H (eds). Cancer control opportunities in low- and middle-income countries. Institute of Medicine , The National Academies Press, Washington , D.C. , 2008.

Committee on the Economics of Antimalarial Drugs (Arrow KJ, Danzon PM, Greenwood BM, Kindermans J-M, Laxminarayan R, Mills AJ, Mshinda H, Mwabu G, Peto R, Ridley RG, White NJ) Executive Summary. In: Arrow KJ, Panosian CB, Gelband H (eds). Saving Lives, Buying Time: Economics of malaria drugs in an age of resistance. Institute of Medicine , The National Academies Press, Washington , D.C. , 2008.

CRP CHD Genetics Collaboration. Collaborative pooled analysis of data on C-reactive protein gene variants and coronary disease: judging causality by Mendelian randomisation. Eur J Epidemiol 2008; 23: 531-540.

Dangour AD, Breeze E, Clarke R, Shetty PS, Uauy R, Fletcher AE. Plasma homocysteine, but not folate or vitamin B-12, predicts mortality in older people in the United Kingdom.. J Nutr. 2008;138:1121-8.

Dearden C, Wade R, Else M, Richards S, Milligan D, Hamblin T, Catovsky D. The prognostic significance of a positive direct antiglobulin test in chronic lymphocytic leukemia – a beneficial effect of the combination of fludarabine and cyclophosphamide on the incidence of hemolytic anemia. Blood 2008; 111(4):1820-1826

Early Breast Cancer Trialists' Collaborative Group (Secretariat Clarke M, Collins R, Darby S, Davies C, Elphinstone P, Evans V, Godwin J, Gray R, Hicks C, James S, MacKinnon E, P McGale, McHugh T, Peto R, Taylor C, Wang Y). Adjuvant polychemotherapy in oestrogen-receptor-poor breast cancer: patient level meta-analysis of randomised trials. Lancet 2008; 371: 29-40.

Eisenstein EL, Collins R, Cracknell BS, Podesta O, Reid ED, Sandercock P, Shakhov Y, Terrin ML, Sellers MA, Califf RM, Granger CB, Diaz R. Sensible approaches for reducing clinical trial costs. Clin Trials 2008; 5: 75-84

Else M, Smith AG, Cocks K, Richards SM, Crofts S, Wade R, Catovsky D, on behalf of the UK NCRI CLL Trials Group. Patients' experience of chronic lymphocytic leukaemia: baseline health-related quality of life results from the LRF CLL4 trial. Br. J. Haematol. 2008; 143: 690-697 (doi:10.1111/j.1365-2141.2008.07407.x).

Fearn T, Hill DC , Darby SC. Measurement error in the explanatory variable of a binary regression: regression calibration and integrated conditional likelihood in studies of residential radon and lung cancer. Statistics in Medicine 2008; 27:2159-2176.

Gasowski J, Li Y, Kuznetsova T, Richart T, Thijs L, Grodzicki T, Clarke R, Staessen JA. Is “usual” blood pressure a proxy for 24-h ambulatory blood pressure in predicting cardiovascular outcomes? Am J Hypertension 2008; 21: 994-100.

Goldstone AH, Richards SM, Lazarus HM, Tallman MS, Buck G, Fielding AK, Burnett AK, Chopra R, Wiernik PH, Foroni L, Paietta E, Litzow MR, Marks DI, Durrant J, McMillan A, Franklin IM, Luger S, Ciobanu N, Rowe JM. In Adults with Standard-Risk Acute Lymphoblastic Leukemia (ALL) the Greatest Benefit is Achieved from a Matched Sibling Allogeneic Transplant in First Complete Remission (CR) and an Autologous Transplant is less Effective than Conventional Consolidation/Maintenance Chemotherapy in All Patients : Final Results of the International ALL Trial (MRC UKALL XII/ ECOG E2993) Blood 2008; 111(4):1827-33.

Gomes M, Faiz MA, Gyapong J, Warsame M, Agbenyega T, Babiker A, Baiden F, Bin Yunus E, Binka F, Clerk C, Folb P, Hossain M A, Kimbute O, Kitua A, Krishna S, Makasi C, Mensah N, Mrango Z, Olliaro P, Peto R, Peto TJ, Rahman MR, Ribeiro I, Samad R, White NJ, for the Study 13 Research Group. Pre-referral rectal artesunate to prevent death and disability in severe malaria: placebo-controlled trial. Lancet 2008 (Published online 8 December 2008 ; DOI:10.1016/S0140-6736(08)61734-1).

Gray R, Collins R, Peto R, Wheatley K. Large-scale randomized evidence: trials and overviews. in: Price P, Sikora K, Illidge T (eds) Treatment of Cancer. Fifth Edition, Chapter 56, pp. 1338-51. Hodder Arnold: 2008.

Independent Advisory Group on Non-ionising Radiation (Chairman: A Swerdlow Members: L Challis, D Coggan, L Coulton, S Darby, P Gowland, P Haggard, D Lomas, D Noble). Static Magnetic Fields. Documents of the Health Protection Agency RCE-6. Health Protection Agency: Oxfordshire. 2008.

Jha P, Gupta PC, Peto R for the Million Death Study Collaborators. Case-control study of smoking and death in India . (Author's reply) NEJM 2008 358: 2844-45.

Jha P, Jacob B, Gajalakshmi V, Gupta PC, Dhingra N, Kumar R, Sinha DN, Dikshit RP, Parida DK, Kamadod R, Boreham J, Peto R for the RGI-CGHR Investigators. A nationally representative case-control study of smoking and death in India NEJM 2008; 358: 1137-47.

Kearney PM, Keech A, Simes J, Collins R, Baigent C. Statins and diabetes. (Response to correspondence). Lancet 2008; 371: 1752.

Landray MJ, Haynes RJ. Commentary: Controversies in NICE guidance on chronic kidney disease. Br Med J 2008;337:a1793 [commentary].

McGale P, Darby SC. Commentary: A dose-response relationship for radiation-induced heart disease - current issues and future prospects. Int J Epidemiol 2008; 37:518-523.

Neil HAW, Perera R, Armitage JM, Farmer AJ, Mant D and Durrington PN on behalf of the Hyperlipidaemia Education and Atherosclerosis Research Trust (HEART UK). Estimated 10-year cardiovascular risk in a British population: results of a national screening project. Int J Clin Pract . 2008; 62: 1322-31

Niewboer A, Burn D, Woods G, Godwin J, Rochester L. Does auditory rhythmical cueing improve gait in people with Parkinson's disease with mild cognitive impairment and dementia? 6th International Congress on Mental Dysfunctions and other Non-Motor Features in Parkinson's Disease and Related Disorders, Dresden 2008; 235. (abstract).

Ostergren J, Poulter NR, Sever PS, Dahlof B, Wedel H, Beevers G, Caulfield M, Collins R, Kjeldsen SE, Kristinsson A, McInnes GT, Mehlsen J, Nieminen M, O'Brien E, for the ASCOT investigators. The Anglo-Scandinavian Cardiac Outcomes Trial: blood pressure-lowering limb: effects in patients with type II diabetes. J Hypertens 2008; 26; 2103-11.

Patel B, Richards SM, Rowe JM, Goldstone AH, Fielding AK . High Incidence Of Avascular Necrosis ( AVN ) In Adolescents With Acute Lymphoblastic Leukaemia ( ALL ); A UKALL XII Analysis. Leukaemia 2008; 22(2):308-12.

Patrono C, Baigent C, Hirsh J, Roth G. Antiplatelet Drugs: American College of Chest Physicians Evidence-Based Guidelines (8th Edition). Chest 2008; 133:199-233.

Peters R, Beckett N, Forette F, Tuomilehto J, Clarke R, Ritchie C, Waldman A, Walton I, Poulter R, Ma S, Comsa M, Burch L, Fletcher A, Bulpitt C; HYVET investigators. Incident dementia and blood pressure lowering in the Hypertension in the Very Elderly Trial cognitive function assessment (HYVET-COG): a double-blind, placebo controlled trial. Lancet Neurol. 2008 (8):683-9.

Peto R, Emberson J, Landray M, Baigent C, Collins R, Clare R, Califf R. Hypothesis-testing Analyses of Cancer Data from Three Ezetimibe Trials. N Engl J Med 2008; 359: 1357-66.

Peto R. David Galton – Reminiscences. Leukemia & Lymphoma 2007; 48: 2293-94.

Pirie K, Beral V, Peto R, Roddam A, Reeves G, Green J, for the Million Women Study Collaborators. Passive smoking and breast cancer in never smokers: prospective study and meta-analysis. Int J Epidemiol 2008 Advance Access 10 June 2008, doi:10.1093/ije/dyn110.

SEARCH Study Collaborative Group (Writing committee: Link E, Parish S, Armitage J, Bowman L, Heath S, Matsuda F, Gut I, Lathrop M, Collins R). SLCO1B1 variants and statin-induced myopathy — A genomewide study. NEJM 2008; 359: 789-99.

Sellick GS. Wade R, Richards S, Oscier DG, Catobsky D, Houlston RS. Scan of 977 non-synonymous SNPs in CLL4 trial patients for the identification of genetic variants influencing prognosis. Blood 2008; 111(3):1625-33.

Sever P, Poulter NR, Dahlof B, Wedel H, Beevers DG, Caulfield M, Collins R, Kjeldsen SE, Kristinsson A, McInnes G, Mehlsen J, Nieminen MS, O'Brien E, Őstergren J on behalf of the ASCOT Investigators. The Anglo-Scandinavian cardiac outcomes trial lipid lowering arm: extended observations 2 years after trial closure. Eur Heart J 2008; 29(4):499-508.

Smith M, Zhou MG, Whitlock G, Yang GH, Offer A, Gei H, Peto R, Huang ZJ, Chen ZM. Oesophagus cancer and body mass index: results from a prospective study of 220,000 men in China and a meta-analysis of published studies. Int J Cancer 2008;122(7):1604-10.

Specchia C, Barlera S, Chiodini B D, Nicolis E, Farrall M, Peden J, Collins R, Watkins H, Tognoni G, Franzosi MG on behalf of the PROCARDIS Consortium. Quantitative trait genetic linkage analysis of Body-Mass Index in familial coronary artery disease. Human Heredity 2008; 66: 19-24.

Swerdlow AJ, Peto R, Doll R. Epidemiology of cancer. In: Oxford Textbook of Medicine. (ed DA Warrell). Oxford University Press, 2008.

Taylor CW, McGale P, Povall JM, Thomas E, Kumar S, Dodwell D, Darby SC. Estimating cardiac exposure from breast cancer radiotherapy in clinical practice. Int. J. Radiation Oncology Biol Phys. doi:10.1016/j.ijrobp.2008.05.066.

Taylor CW, Nisbet A, McGale P, Goldman U, Darby SC, Hall P, Gagliardi G. Cardiac doses from Swedish breast cancer radiotherapy since the 1950s. Radiother Oncol . 2009 Jan;90(1):127-35.

Taylor CW, Povall JM, McGale P, Nisbet A, Dodwell D, Smith JT, Darby SC. Cardiac dose from tangential breast cancer radiotherapy in the year 2006 Int. J. Radiation Oncology Biol Phys 2008; 72:501–507.

Taylor GM, Richards S, Wade R, Hussain A, Simpson J, Hill F, Mitchell C & Eden T on behalf of UKCCS and CCLG Investigators Relationship between HLA-DP supertype and survival in childhood acute lymphoblastic leukaemia: evidence for selective loss of immunological control of residual disease? BJHaem 2009;(doi:10.1111/j.1365-2141.2008.07571.x).

Willer CJ*, Sanna D*, Jackson AU, Scuteri A, Bonnycastle LL, Clarke R, Heath SC, Timpson NJ, Najjar SS, Stringham HM, Strait J, Duren WL, Maschio A, Busonero F, Mulas A, Albai G, Swift AJ, Morken MA, Narisu N, Bennett D, Parish S, Shen H, Galan P, Meneton, P Hercberg S, Zelenika D, Chen W-M, Li Y, Sundvall J, Watanabe RM, Nagaraja R, Ebrahim S, Lawlor DA, Ben-Shlomo Y, Davey-Smith G, Shuldiner AR, Collins R, Bergman RN, Uda M, Tuomilehto J, Cao A, Collins FS, Lakatta E, Lathrop GM, Boehnke M, Schlessinger D, Mohlke KL, Abecasis GR. Newly identified loci that influence lipid concentration and risk of coronary artery disease. Nat Genet 2008; 40(2):161-9.

Winkels RM, Brouwer IA, Clarke R, Katan MB, Verhoef P. Bread cofortified with folic acid and vitamin B-12 improves the folate and vitamin B-12 status of healthy older people: a randomized controlled trial. Am J Clin Nutr. 2008; 88(2):348-55.

Yusuf S, Bosch J, Devereaux PJ, Collins R, Baigent C, Granger C, Califf R, Temple R. Sensible guidelines for the conduct of large randomized trials. Clin Trials 2008; 5; 38-39 (published online doi: 10.1177/1740774507088099 at http://ctj.sagepub.com

Zhou M, Offer A, Yang G, Smith M, Hui G, Whitlock G, Collins R, Huang Z, Peto R, Chen Z. Body mass index, blood pressure and mortality from stroke: a nationally representative prospective study of 212 000 Chinese men. Stroke 2008; 39: 753-59.

Publications in 2007

Armitage J. The safety of statins in clinical practice. 2007 Lancet 2007; 370:1781-90

Armitage J, Souhami R, Friedman L, Hilbrich L et al. The impact of privacy and confidentiality law on the conduct of clinical trials. Clinical Trials. 2007 (in press)

B-Vitamin Treatment Trialists' Collaboration (Writing Committee: Clarke R, Armitage J, Lewington S, Collins R) Homocysteine-lowering trials for prevention of vascular disease: protocol for a collaborative meta-analysis. Clin Chem Lab Med 2007; 45: 1575-81

Baigent C, C larke R. B-Vitamins for prevention of vascular disease: insufficient evidence to justify treatment. JAMA 2007; 298: 1212-4

Baigent C, Harrell F, Buyse M, Emberson J, Altman D. Ensuring trial validity by data quality assurance and diversification of monitoring methods. Clinical Trials (in press)

Baigent C, Landray MJ. Which cardiovascular risk factors matter in chronic kidney disease? Nephrol Dial Transplant 2007; 22:9-11

Baigent C, Landray MJ, Wheeler DC. Misleading associations between cholesterol and vascular outcomes in dyalisis patients: the need for randomized trials. Seminars in dialysis 2007; 20:498-503

Baigent C, Peto R, Gray R, Parish S, Collins R. Large-scale randomised evidence: trials and meta-analyses of trials. In: Warrell DA et al (eds), Oxford Textbook of Medicine, 5th edition, 2008. (in press)

Bennet AM, Di Angelantonio E, Ye Z, Wensley F, Dahlin A, Ahlbom A, Keavney B, Collins R, Wiman B, de Faire U, Danesh J. Association of apolipoprotein E genotypes with lipid levels and coronary risk. JAMA 2007; 298: 1300-11

Bennett DA, Xu P, Clarke R, Zondervan K, Parish S, Palmer A, Cardon L, Peto R, Lathrop M, Collins R for the International Study of Infarct Survival (ISIS) Collaborators. The exon 1 -8C/G SNP in the PSMA6 gene contributes only a small amount to the burden of myocardial infarction in 6946 cases and 2720 controls from a United Kingdom (UK) population. Eur J Hum Gen 2007 (in press)

Blood Pressure Lowering Treatment Trialists' Collaboration (Baigent C, member of Executive Committee). Blood pressure dependent and independent effects of agents that inhibit the rennin-angiotensin system. J Hypertens 2007; 25:951-8

Bosetti C, Gallus S, Peto R, Negri E, Talamini R, Tavani A, Franceschi S, La Vecchia C. Smoking, smoking cessation and cumulative risk of upper aero-digestive tract cancers. Am J Epid 2007 (in press)

Brennan P, McKay J, Moore L, Zaridze D, Mukeria A, Szeszenia-Dabrowska N, Lissowska J, Rudnai P, Fabianova E, Mates D, Bencko V, Foretova L, Janout V, Chow W-H, Rothman N, Chabrier A, Gaborieau V, Odefrey F, Southey M, Hashibe M, Hall J, Boffetta P, Peto J, Peto R, J Hung RJ. Uncommon CHEK2 mis-sense variant and reduced risk of tobacco-related cancers: case-control study. Human Molecular Genetics 2007; 16: 1794-801

Broadbent HM, Peden JF, Lorkowski S, Goel A. Ongen H, Green F, Clarke R, Collins R, Franzosi MG, Tognoni G, Seedorf U, Rust S, Eriksson P, Hamsten A, Fararall M, Watkins H for the PROCARDIS consortium. Susceptibility to coronary artery disease and diabetes is encoded by distinct, tightly linked, SNPs in the ANRIL locus on chromosome 9p. Hum Molecular Genet 2007 (in press)

Bulbulia R, Bowman L, Wallendszus K, Parish P, Armitage J, Collins R. MRC/BHF Heart Protection Study ( HPS ): Mortality, cancer incidence and major vascular events during 4 years of post-trial follow-up of HPS . Am Coll Card 2007; 393A: 820-5

Clarke L, Clarke M, Clarke T. How useful are Cochrane reviews in identifying research needs?. Journal of Health Services Research and Policy 2007; 12: 101-3

Clarke M. The Cochrane Collaboration and systematic reviews. British Journal of Surgery 2007; 94: 391-2

Clarke M, Hopewell S, Chalmers I. Reports of clinical trials should begin and end with up-to-date systematic reviews of other relevant evidence: a status report. Journal of the Royal Society of Medicine 2007; 100: 187-90

Clarke M for the Sustainable Trials Study Group. Towards sustainable clinical trials. BMJ 2007; 334: 671-3

Clarke M. The Cochrane Collaboration and the Cochrane Library. Otolaryngology – Head and Neck Surgery 2007; 137:S52-4

Clarke R, Emberson JR, Parish S, Palmer A, Shipley M, Linksted P, Sherliker P, Clark S, Armitage J, Fletcher A, Collins R. Cholesterol fractions and apolipoproteins as risk factors for heart disease mortality in older men. Arch Intern Med.2007; 167: 1373-8

Clarke R, Lewington S, Sherliker P, Armitage J. Effects of B-vitamins on plasma homocysteine concentrations and on risk of cardiovascular disease and dementia. Current Opinion in Nutrition and Metabolism 2007; 10: 32-9

Clarke R, Sherliker P, Hin H, Nexo E, Hvas AM, Schneede JM, Birks J, Ueland PM, Emmens K, Scott JM, Evans JG. Detection of vitamin B12 deficiency in older people by vitamin B12 or holotranscobalamin, the active fraction of vitamin B12. Clin Chemistry 2007; 53: 963-70

Clarke R, Shipley M, Breeze E, Collins R, Marmot M, Halsey J, Fletcher A, Hemingway H. Influence of angina on survival in 6655 older men: the Whitehall study. Eur J Cardiovasc Prevention and Rehabilitation 2007; 14: 280-6

Clarke R, Armitage J, Lewington S, Collins R for the B-Vitamin Treatment Trialists' Collaboration. Homocysteine-lowering trials for prevention of vascular disease: protocol for a collaborative meta-analysis. Clin Chem Lab Med 2007; 45:1575-81

Clarke R. Homocysteine-lowering vitamin B supplements do not improve cognitive performance in healthy older adults after two years. Evid Based Ment Health. 2007; 10:27

Clarke R. Homocysteine, B-vitamins and risk of dementia. A J Clin Nutr 2007; 85: 329-30

Clarke R. Brain. In: Stanner S (ed). Diet, Nutrition and Ageing. British Nutritional Foundation, London . Blackwell Scientific Publications. 2007

Clarke R, Birks J, Nexo E, Ueland PM, Schneede PM, Scott J, Molloy A, Frost C, Evans JM. Low vitamin B12 status and risk of cognitive decline in older adults. Am J Clin Nutr 2007 ; 86:1384-91

Collaborative Group on Epidemiological Studies of Ovarian Cancer. Ovarian cancer and oral contraceptives: collaborative reanalysis of data from 45 epidemiological studies including 23,257 women with ovarian cancer and 87,303 controls. Lancet 2007 (submitted)

Collins R, MacMahon S. Reliable assessment of the effects of treatments on mortality and major morbidity. In: THE LANCET Treating individuals: from randomised trials to personalized medicine. pp.3-35 (ed. Rothwell, PM) Elsevier, 2007

CML autograft trials collaboration. Autologous stem cell transplantation in chronic myeloid leukaemia: A meta-analysis of six randomized trials. Cancer Treatment Reviews 2007; 33: 39-47 (doi: 10.1016/j.ctrv.2006.10.002)

Critical Leg Ischaemia Prevention Study Group (CLIPS) (writing committee: Catalano M, Born G, Peto R). Prevention of serious vascular events by aspirin among patients with peripheral arterial disease: randomised, double-blind trial. J Intern Med 2007; 261: 276-84

Darby S, Taylor C, McGale P, Ewertz M, Whelan T. Overviews of Randomized Trials of Radiotherapy in Early Breast Cancer: Importance of Long-term Follow-up and Cause-specific Mortality. Lead article (pp 3-6) in ASCO 2007 Educational Book

Darby S, Kan S, Spooner R, Giangrande P, Hill F, Hay C, Lee C, Ludlam C, Williams M for the UK Haemophilia Centre Doctors' Organisation. Mortality rates, life expectancy and causes of death in people with haemophilia A or B in the United Kingdom who were not infected with HIV. Blood 2007; 110: 815-25

De Caterina R, Husted S, Wallentin L, Agnelli G, Bachmann F, Baigent C et al. Anticoagulants in heart disease: current status and perspectives. Eur Heart J 2007; 28:880-913

Dearden C, Wade R, Else M, Richards S, Milligan D, Hamblin T, Catovsky D. The prognostic significance of a positive direct antiglobulin test in chronic lymphocytic leukemia – a beneficial effect of the combination of fludarabine and cyclophosphamide on the incidence of hemolytic anemia. Blood 2007 (Prepublished online Nov 30, 2007 , doi:10.1182/blood-2007-07-101303 )

Devane D, Begley CM, Clarke M, Horey D, OBoyle C. Evaluating maternity care: a core set of outcome measures. Birth 2007; 34:164-70

Early Breast Cancer Trialists' Collaborative Group. Adjuvant polychemotherapy in oestrogen-receptor-poor breast cancer: meta-analysis of individual patient data from the randomised trials. Lancet 2007 (in press)

Eisinga A, Siegfried N, Clarke M. The sensitivity and precision of search terms in Phases I, II and III of the Cochrane Highly Sensitive Search Strategy for identifying reports of randomized trials in Medline in a specific area of health care – HIV/AIDS prevention and treatment interventions. Health Info Libr J 2007; 24:103-9

Eussen SJ , Ueland PM , Clarke R , Blom HJ , Hoefnagels WH , van Staveren WA , de Groot LC . The association of betaine, homocysteine and related metabolites with cognitive function in Dutch elderly people. Br J Nutr 2007; 98:960 - 8

Fearn T, Hill DC, Darby SC. Measurement error in the explanatory variable of a binary regression: regression calibration and integrated conditional likelihood in studies of residential radon and lung cancer. Statistics in Medicine (in press)

Fielding AK, Richards SM, Chopra R, Lazarus HM, Litzow M, Buck G, Durrant IJ, Luger SM, Marks DI, McMillan AK , Tallman MS, Rowe JM, Goldstone AH on behalf of the Medical Research Council of the United Kingdom Adult ALL Working Party and the Eastern Co-operative Oncology Group. Outcome of 609 Adults After Relapse of Acute Lymphoblastic Leukaemia ( ALL ); An MRC UKALL12/ECOG 2993 Study. Blood 2007; 109: 944-50 (DOI 10.1182/blood-2006-05-018192)

Gajalakshmi V, Peto R. Suicide rates in rural Tamil Nadu, South India : Verbal autopsy of 39,000 deaths in 1997-98. Int J Epidemiol 2007; 36(1): 203-7

Gajalakshmi V, Peto R, Kanimozhi V C, Whitlock G, Veeramani D. Cohort profile: The Chennai prospective study of mortality among 500,000 adults in Tamil Nadu, South India . Int J Epidemiol (Advance Access published May 17 2007)

Goldstone AH, Richards SM, Lazarus HM, Tallman MS, BuckG, Fielding AK, Burnett AK, Chopra R, Wiernik PH, Foroni L, Paietta E, Litzow MR, Marks DI, Durrant J, McMillan A, Franklin IM, Luger S, Ciobanu N, Rowe JM. In Adults with Standard-Risk Acute Lymphoblastic Leukemia (ALL) the Greatest Benefit is Achieved from a Matched Sibling Allogeneic Transplant in First Complete Remission (CR) and an Autologous Transplant is less Effective than Conventional Consolidation/Maintenance Chemotherapy in All Patients : Final Results of the International ALL Trial (MRC UKALL XII/ ECOG E2993) Blood 2008 (prepublished November 29, 2007: DOI: 10.1182/blood-2007-10-116582

Haynes R, Armitage J. Fluvastatin for reduction of cardiovascular risk in patients with moderate to severe renal insufficiency. Nature Clin Prac Nephrology 2007 (commentary); 3(10):531

Heart Protection Study Collaborative Group (writing committee: Emberson Jr, Ng LL, Armitage J, Bowman L, Parish S, Collins R). N-terminal pro-B-type natriuretic peptide, vascular disease risk and cholesterol reduction among 20,536 patients in the MRC/BHF Heart Protection Study. J Am Coll Cardiol 2007; 49: 311-9

Heart Protection Study Collaborative Group (writing committee: Bulbulia R, Bowman L, Armitage J, Bowman L, Parish S, Collins R, Wallendszus K). Randomized trial of the effects of cholesterol-lowering with simvastatin on peripheral vascular and other major vascular outcomes in 20,536 people with peripheral arterial disease and other high-risk conditions. J Vasc. Surg 2007; 45: 645-54

Hill J, Treasure T, on behalf of the Guidelines Development Group (Baigent C, member). Reducing the risk of venous thromboembolism (deep vein thrombosis and pulmonary embolism) in inpatients having surgery: summary of NICE guidance. BMJ 2007; 334:1053-4

Kearney PM, Blackwell L, Collins R, Keech A, Simes J, Peto R, Armitage J, Baigent C. Efficacy of statin therapy in people with diabetes: meta-analysis of data from 18,686 diabetic participants in 14 randomised trials of statins. Lancet 2007 (in press)

Mafham, MM, Niculescu-Duvax I, Barron J, Emberson JR, Dockrell ME, Landray MJ, Baigent C. A practical method of measuring glomerular filtration rate by iohexol clearance using dried capillary blood spots. Nephron 2007; 106:c104-12

Moorman AV, Richards SM, Robinson HM, Strefford JC, Gibson BES, Kinsey SE, Eden OB, Vora AJ, Mitchell CD and Harrison CJ on behalf of the UK Medical Research Council (MRC) / National Cancer Research Institute ( NCRI ) Childhood Leukaemia Working Party (CLWP). Prognosis of children with acute lymphoblastic leukaemia ( ALL ) and intra-chromosomal amplification of chromosome 21 (iAMP21). Blood 2007; 109: 2327-30.

Moorman AV, Harrison CJ, Buck GAN , Richards SM, Secker-Walker LM, Martineau M, Vance GH, Cherry AM, Higgins RR, Fielding AK, Foroni L, Paietta E, TallmanES , Litzow MR, Wiernik PH, Rowe JM, Goldstone AH, and Dewald GW for the Medical Research Council (MRC) / National Cancer Research Institute ( NCRI ) Adult Leukaemia Working Party of the United Kingdom and the Eastern Cooperative Oncology Group of the United States of America. Karyotype is an independent prognostic factor in adult acute lymphoblastic leukemia ( ALL ): Analysis of cytogenetic data from patients treated on the Medical Research Council (MRC) UKALLXII / Eastern Cooperative Oncology Group (ECOG) 2993 Trial. Blood 2007; 109: 3189-97.

Mozzafarian D, Clarke R. Calculated effects of replacing trans fatty acids with specific fats and oils: lipid effects and clinical outcomes. Eur J Clin Nutr 2008 (In Press)

Neville MN , Clarke R, JG Evans, Karpe G. Absence of relationship between MTP ha plotypes and longevity. J Gerontol A Biol Sci Med Sci. 2007;62: 202-5

Patel B, Richards SM, Rowe JM, Goldstone AH, Fielding AK . High Incidence Of Avascular Necrosis ( AVN ) In Adolescents With Acute Lymphoblastic Leukaemia ( ALL ); A UKALL XII Analysis. Leukemia 2007 (in press)

Peto R. Some epidemiology of Malaria (Foreword to “Saving Lives, Buying Time: The Economics of Malaria Drugs in an age of resistance”, by KJ Arrow). Office of Health Economics, 2007

Peto R. The hazards of smoking and the benefits of stopping: cancer mortality and overall mortality. Introduction (pp15-27) to: IARC handbooks on cancer control. Volume 11: Smoking cessation. IARC, Lyon 2007. (Also a member of the working group responsible for the monograph.)

Peto R. Smoking. In: Sibtain A (ed), Towards the Prevention of Cancer. Section 2, pp.31-8. Royal Society of Medicine, 2007

Pirie K, Beral V, Peto R, Roddam A, Reeves G, Green J, for the Million Women Study Collaborators. Passive smoking and breast cancer in never smokers: prospective study and meta-analysis. Int J Epidemiol 2007; (in press)

Prospective Studies Collaboration (writing committee: Lewington S, Whitlock G, Clarke R, Sherliker P, Emberson J, Halsey J, Qizilbash N, Peto R, Collins R). Blood cholesterol and vascular mortality by age, sex, and blood pressure: a meta-analysis of individual data from 61 prospective studies with 55,000 vascular deaths. Lancet 2007; 370: 1829-39

Ramanujachar R, Richards S, Webb D, Goldstone A, Mitchell C, Vora A, Rowe J, Hann I. Adolescents with acute lymphoblastic leukaemia: outcome on UK national paediatric ( ALL 97) and adult (UKALLXII/E2993) trials Pediatric Blood & Cancer 2007; 48: 254-61 (DOI 10.1002/pbc.20749)

Roychoudhuri R, Robinson D, Putcha V, Cuzick J, Darby S, Møller H (2007). Increased cardiovascular mortality more than fifteen years after radiotherapy for breast cancer: a population-based study. BMC Cancer 2007, 7:9 doi:10.1186/1471-2407-7-9

SEARCH Study Collaborative Group (Bowman L, Armitage J, Bulbulia R, Parish S, Collins R,) Study of the Effectiveness of Additional Reductions in Cholesterol and Homocysteine (SEARCH): Characteristics of a randomised trial among 12,064 myocardial infarction survivors. Am Heart J 2007; 154:815-23

Sellick GS. Wade R, Richards S, Oscier DG, Catobsky D, Houlston RS. Scan of 977 non-synonymous SNPs in CLL4 trial patients for the identification of genetic variants influencing prognosis. Blood 2007 (prepublished online November 15, 2007; DOI 10.1182/blood-2007-08-110130)

Sever P, Poulter NR, Dahlof B, Wedel H, Beevers DG, Caulfield M, Collins R, Kjeldsen SE, Kristinsson A, McInnes G, Mehlsen J, Nieminen MS, O'Brien E, Őstergren J on behalf of the ASCOT Investigators. The Anglo-Scandinavian cardiac outcomes trial lipid lowering arm: extended observations 2 years after trial closure. Eur Heart J 2007 (in press)

Shah E, Clarke M. STROBE: New standards for reporting observational epidemiology, a chance to improve. Int J Epidemiol 2007; 36:946-8

Smith M, Zhou MG, Whitlock G, Yang GH, Offer A, Gei H, Peto R, Huang ZJ, Chen ZM. Oesophagus cancer and body mass index: results from a prospective study of 220,000 men in China and a meta-analysis of published studies. Int J Cancer 2007 (in press)

Smith V, Devane D, Begley CM, Clarke M, Higgins S. A systematic review and quality assessment of systematic reviews of fetal fibronectin and transvaginal length for predicting preterm birth. Eur J Obstet Gynecol Reprod Biol 2007; 133:134-42

Specchia C, Barlera S, Chiodini B D, Nicolis E, Farrall M, Peden J, Collins R, Watkins H, Tognoni G, Franzosi MG on behalf of the PROCARDIS Consortium. Quantitative trait genetic linkage analysis of Body-Mass Index in familial coronary artery disease. Human Heredity (in press)

Taylor CW, Nisbet A, McGale P, Darby SC. Cardiac exposures in breast cancer radiotherapy: 1950s-1990s. Int J Radiat Oncol Biol Phys. 2007; 69:1484–95

Taylor CW, Povall JM, McGale P, Nisbet A, Dodwell D, Smith JT, Darby SC. Cardiac dose from contemporary tangential breast cancer radiotherapy Int J Radiat Oncol Biol Phys. (in press)

Ueland PM, Clarke R. Homocysteine and cardiovascular risk: considering the evidence in the context of study design, folate fortification, and statistical power. Clin Chem 2007; 53: 1-3

UK Clinical Research Collaboration (R Collins; member of simulation team). UKCRC R&D Advisory Group to Connecting for Health. Report of Research Simulations. 2007

Willer CJ*, Sanna D*, Jackson AU, Scuteri A, Bonnycastle LL, Clarke R, Heath SC, Timpson NJ, Najjar SS, Stringham HM, Strait J, Duren WL, Maschio A, Busonero F, Mulas A, Albai G, Swift AJ, Morken MA, Narisu N, Bennett D, Parish S, Shen H, Galan P, Meneton, P Hercberg S, Zelenika D, Chen W-M, Li Y, Sundvall J, Watanabe RM, Nagaraja R, Ebrahim S, Lawlor DA, Ben-Shlomo Y, Davey-Smith G, Shuldiner AR, Collins R, Bergman RN, Uda M, Tuomilehto J, Cao A, Collins FS, Lakatta E, Lathrop GM, Boehnke M, Schlessinger D, Mohlke KL, Abecasis GR. Genoma-wide association scans identify novel loci that influence lipid levels and risk of coronary artery disease. Nature Genet 2007 (in press)

Zehnder D, Landray MJ, Wheeler DC, Fraser W, Blackwell L, Nuttall S, Hughes SV, Townend J, Ferro C, Baigent C, Hewison M. Coss-sectional analysis of abnormalities of mineral homeostasis, vitamin D and parathyroid hormone in a cohort of pre-dialysis patients. The chronic renal impairment in Birmingham (CRIB) study. Nephron 2007; 107:c109-16

Zhou MG, Offer A, Yang GH, Smith M, Gei H, Whitlock G, Collins R, Huang ZJ, Peto R, Chen ZM. Body mass index, blood pressure and mortality from stroke: a nationally representative prospective study of 212 000 Chinese men. Stroke 2007 (in press)

Publications in 2006

Academy of Medical Sciences Working Group (writing committee: Chalmers S, Collins R, Luker K, Newton J, Silman A, Souhami R, Watt G, Wessely S, Zimmern R) Personal data for public good: using health information in medical research: A Report from the Academy of Medical Sciences. Acad Med Sci January 2006

Advisory Group on Non-ionising Radiation (Chairman: Swerdlow A; Members: Challis L, Coggon D, Coulton L, Darby S, Gowland P, Haggard P , Lomas D, Noble D) (2006). Power Frequency Electromagnetic Fields, Melatonin and the Risk of Breast Cancer. Documents of the Health Protection Agency, Series B: Radiation, Chemical and Environmental Hazards. RCE-1. Health Protection Agency, UK

Allen C, Clarke M. International activity in Cochrane Review Groups with particular reference to China. Chinese Journal of Evidence-based Medicine 2006; 6: 541-5

Baigent C, Keech A, Kearney P, Collins R, Simes J, on behalf of the CTT Collaboration. Efficacy and safety of cholesterol-lowering treatment. Lancet 2006; 367: 470-1

Barlera S, Specchia C, Farrall M, Chiodini BD, Franzosi MG, Rust S, Green F, Nicolis EB, Peden J, Assmann G, Collins R, Hamsten A, Tognoni G, Watkins H on behalf of the PROCARDIS Consortium. Multiple QTL influence the serum Lp(a) concentration: a genome-wide linkage screen in the PROCARDIS study. Eur J Human Genet 2006, doi:10.1038/sj.ejhg.5201732, advance online publication 29 Nov 2006

Boffetta P, Clark S, Shen M, Gislefoss R, Peto R, Andersen A. Serum cotinine level as predictor of lung cancer risk. Cancer Epidemiol Biomarkers Prev 2006; 15: 1184-88

Breeze E, Clarke R, Shipley MJ, Marmot MG, Fletcher AE. Cause-specific mortality in relation to body mass index in middle and in old age. Int J Epidemiol 2006; 35: 169-78

Brown P, Brunnhuber K, Chalkidou K, Chalmers I, Clarke M, Fenton M, Forbes C, Glanville J, Hicks NJ, Moody J, Twaddle S, Timimi H, Young P. How to formulate research recommendations. BMJ 2006; 333: 804-6

Burton M, Clarke M. Systematic reviews of surgical interventions. Surgical Clinics of North America 2006; 86: 101-14

Cardis E, Krewski D, Boniol M, Drozdovitch V, Darby SC, Gilbert ES, Akiba S, Benichou J, Ferlay J, Gandini S, Hill C, Howe G, Kesminiene A, Moser M, Sanchez M, Storm H, Voisin L, Boyle P (2006) Estimates of the Cancer Burden in Europe from Radioactive Fallout from the Chernobyl Accident. International Journal of Cancer 119, 1224-35

Chen J, Peto R, Pan W, Liu B, Campbell TC, Boreham J, Parpia B, Cassano P, Chen Z, Feng Z, Gelband H, Li J, Pan H, Root M, Wu Y and Youngman D. 2006. Mortality, Biochemistry, Diet and Lifestyle in Rural China: geographic study of the characteristics of 69 counties in mainland China and 16 areas in Taiwan. Oxford University Press, Oxford

Chen Z, Yang G, Zhou M, Smith M, Offer A, Ma J, Wang L, Pan H, Whitlock G, Collins R, Niu S, Peto R. Body mass index and mortality from ischaemic heart disease in a lean population: 10 year prospective study of 220,000 adult men. Int J Epidemiol 2006; 35: 141-50

Chen Z, Collins R, Peto R, Xie J, Jiang L, Liu L. Clopidogrel and metoprolol in myocardial infarction. (Authors’ reply) Lancet 2006; 367: 813

Clarke M, Hopewell S, Juszczak E, Eisinga A, Kjeldstrom M. Compression stockings for preventing deep vein thrombosis in airline passengers. Cochrane Database of Systematic Reviews (Issue 2) CD004002. DOI: 10.1002/14651858.CD004002.pub2. 2006

Clarke M. Should systematic reviews be seen as original research? J Health Serv Res Pol 2006; 1: 192

Clarke M. Systematic reviews: new challenges relating to non-randomised studies and diagnostic test accuracy. Chinese Journal of Evidence-Based Medicine 2006; 6: 236-9

Clarke M. The 1944 Patulin Trial of the British Medical Research Council. J Roy Soc Med 2006; 99: 478-80

Clarke M. The Cochrane Collaboration. In: Killoran A, Swann C, Kelly MP, editors. Public health evidence: tackling health inequalities. Oxford: Oxford University Press, 2006: 115-23

Clarke R. Vitamin B12, folic acid, and the prevention of dementia. New Engl J Med 2006; 354; 26: 2817-19

Clarke R, Armitage J, Lewington S, Sherliker P, Collins R on behalf of the B-Vitamin Treatment Trialists’ Collaboration. Homocysteine lowering trials for prevention of cardiovascular events: a review of the design and power of the large randomized trials. Am Heart J 2006; 151: 282-7

Clarke R, Lewington S. Trans fatty acids and coronary heart disease. BMJ 2006; 333: 21

Clarke R, Peng X, Bennett D, Lewington S, Zondervan K, Parish S, Palmer A, Clark S, Cardon L, Peto R, Lathropp M, Collins R for the International Study of Infarct Survival (ISIS) collaborators. Lymphotoxin-alpha gene and risk of myocardial infraction in 6928 cases and 2712 controls in the ISIS case-control study. PLoS Genetics 2006; 2; e107, 990-6

Darby S, Hill D, Auvinen A, Barros-Dios JM, Baysson H, Bochicchio F, Deo H, Falk R, Farchi S, Figueiras A, Hakama M, Heid I, Hunter N, Kreienbrock L, Kreuzer M, Lagarde F, Mäkeläinen I, Muirhead C, Oberaigner W, Pershagen G, Ruosteenoja E, Schaffrath Rosario A, Tirmarche M, Tomášek L, Whitley E, Wichmann HE, Doll R (2006). Residential Radon and Lung Cancer: Detailed Results of a Collaborative Analysis of Individual Data on 7,148 Subjects with Lung Cancer and 14, 208 Subjects without Lung Cancer from 13 Epidemiological Studies in Europe. Scandinavian Journal of Work, Environment and Health 32, supplement 1

Darby S, McGale P, Peto R, Taylor C. Effects of radiotherapy and surgery for early breast cancer. Lancet 2006; 367: 1654-55

Davies C, Collins R. Balancing potential risks and benefits of using confidential data. BMJ 2006, 333: 349-51

Devlin AM, Clarke R, Birks J, Evans JE, Halsted CH. Interactions among polymorphisms in folate-metabolizing genes and serum total homocysteine levels in healthy elderly population. Am J Clin Nutr 2006; 83: 708-13

Doll R, Peto R. The Hazards of Smoking and the Benefits of Stopping. In: Understanding nicotine and tobacco addiction. (Novartis Foundation Symposium275), pp.3-16. Wiley, Chichester 2006

Eussen SJ, deGroot LC, Joosten LW, Bloo RJ, Clarke R, Ueland PM, Schneede J, Blom HJ, Hoefnagels WH, van Staveren WA. Effect of oral vitamin B-12 with or without folic acid on cognitive function in older people with mild vitamin B-12 deficiency: a randomized, placebo-controlled trial. Am J Clin Nutr 2006; 84: 361-70

Farrall M, Green FR, Peden JF, Olsson PG, Clarke R, Hellenius M-L, Rust S, Lagercrantz J, Franzosi MG, Schulte H, Carey A, Olsson GO, Assmann G, Tognoni G, Collins R, Hamsten A, Watkins H. Genome-wide mapping of susceptibility to coronary artery disease identifies a novel replicated locus on chromosome 17. PLoS Genetics 2006; 2(5): 755-61

Gnanalingham KK, Apostolopoulos V, Barazi S, O'Neill K. The impact of the international subarachnoid aneurysm trial (ISAT) on the management of aneurysmal subarachnoid haemorrhage in a neurosurgical unit in the UK. Clinical Neurology & Neurosurgery 2006; 108: 117-23

Heart Protection Study Collaborative Group (writing committee: Mihaylova B, Briggs A, Armitage J, Parish S, Gray A, Collins R). Lifetime cost-effectiveness of simvastatin in a range of risk groups and age groups derived from a randomised trial of 20,536 people. BMJ 2006; 333: 1145-48

Hennekens CH, Hollar D, Baigent C. Gender differences in response to aspirin in cardiovascular disease: an hypothesis formulated, but not tested. Nat Clin Pract Cardiovasc Med 2006, 3: 4-5

Hin H, Clarke R et al. Clinical relevance of vitamin B12 in older people: Banbury B12 study. Age and Aging 2006; 35: 416-22

Hopewell S, Clarke M, editors. The Cochrane Collaboration Methods Groups Newsletter Supplement 2006; 10: 1-38

Hopewell S, Clarke M, editors. The Cochrane Collaboration Methods Groups Newsletter 2006; 10: 1-35

Hopewell S, McDonald S, Clarke M, Egger M. Grey literature in meta-analyses of randomized trials of health care interventions [Update]. Cochrane Database of Methodology Reviews 2006, Issue 2. Art. No.: MR000010. DOI: 10.1002/14651858.MR000010.pub2

Jha P, Gajalakshmi V, Gupta PC, Kumar R, Mony P, Dhingra N, Peto R, RGI-CGHR Prospective Study Collaborators. Prospective study of one million deaths in India: rationale, design, and validation results. PLoS Medicine 2006; 3: 191-200

Jha P , Peto R, Zatonski W, Boreham J, Jarvis MJ and Lopez AD. Social inequalities in male mortality, and in male mortality from smoking: indirect estimation from national death rates in England and Wales, Poland, and North America. Lancet, 2006; 368: 367-70

Kearney PM, Baigent C, Godwin J, Halls H, Emberson JR, Patrono C. Do coxibs and traditional non-steroidal anti-inflammatory drugs increase the risk of atherothrombosis? Meta-analysis of randomized trials. BMJ 2006; 332: 1302-05

Kearney PM, Baigent C. Statins: are any questions unanswered? Curr Opin Lipidol 2006; 17: 418-25

Keavney B, Danesh J, Parish S, Palmer A, Clark S, Youngman L, Delépine M, Lathrop M, Peto R, Collins R, for The International Studies of Infarct Survival (ISIS) Collaborators. Fibrinogen and coronary heart disease: test of causality by "Mendelian randomisation". Int J Epidemiol 2006; 35: 935-43

Landray M, Baigent C, Leaper C, Adu D, Altmann P, Armitage J, Ball S, Baxter A, Blackwell L, Cairns HS, Carr S, Collins R, Kourellias K, Rogerson M, Scoble JE, Tomson CRV, Warwick G, Wheeler DC. The second United Kingdom Heart and Renal Protection study (UK-HARP-II): a randomized controlled study of the biochemical safety and efficacy of adding ezetimibe to simvastatin as initial therapy among patients with chronic kidney disease. Am J Kid Dis 2006; 47: 385-95

Lazarus HM, Richards SM, Chopra R, Litzow MR, Burnett AK, Wiernik PH, Franklin IM, Tallman MS, Cook L, Buck G, Durrant IJ, Rowe J, Goldstone AH, for the Medical Research Council (MRC)/National Cancer Research Institute (NCRI) Adult Leukaemia Working Party of the United Kingdom and the Eastern Cooperative Oncology Group Central nervous system involvement in adult acute lymphoblastic leukemia at diagnosis: results from the international ALL trial MRC UKALL XII/ECOG E2993. Blood 2006; 108: 465-72

Lennard L, Richards S, Cartwright CS, Mitchell C, Lilleyman JS, Vora A on behalf of the UK MRC/NCRI Childhood Leukaemia Working Party. The Thiopurine Methyltransferase Genetic Polymorphism is associated with Thioguanine-Related Veno-Occlusive Disease of the Liver in Children with Acute Lymphoblastic Leukaemia. Clin Pharm Therap 2006; 80: 373-83

Liu BQ, Jian JM, Chen ZM, Chen JS, Zhang KL, et al. Relationship between tobacco smoking and oesophagus cancer in China: a large population-based case-control study. Chinese Med J 2006; 86: 380-5

Okebe JU, Lasserson TJ, Meremikwu MM, Richards S. Therapeutic interventions for Burkitt’s lymphoma in children. Cochrane Database of Systematic Reviews 2006, Issue 4. Art. No.: CD005198. DOI: 10.1002/14651858. CD005198.pub2

Peto R, Doll R. The Hazards of Smoking and the Benefits of Stopping. In: Understanding nicotine and tobacco addiction. (Novartis Foundation Symposium 275), pp.3-16. Wiley, Chichester 2006

Peto R, Lopez ad, Boreham J, Thus M. Mortality from smoking in developed countries 1950-2000 (2nd edition: 500-page monograph plus CD)

Popat S, Chen ZM, Zhao D, Pan H, Hearle, N, Chandler I, et al. A prospective, blinded analysis of thymidylate synthase and p53 expression as prognostic markers in the adjuvant treatment of colorectal cancer. Ann Oncology 2006 17:1810-7

Ramanujachar R, Richards S, Hann I, Webb D. Adolescents with acute lymphoblastic leukaemia: emerging from the shadow of paediatric and adult treatment protocols Ped Blood Cancer 2006; 47: 748-56

Stem Cell Trialists’ Collaborative Group. Individual patient data meta-analysis of allogeneic peripheral blood stem cell transplant vs. bone marrow transplant in the management of hematological malignancies: indirect assessment of the effect of day 11 methotrexate administration. Bone Marrow Transplantation 2006; 38: 539 – 46

Steurer M, Pall G, Richards S, Schwarzer G, Bohlius J, Greil R. Purine Antagonists for Chronic Lymphocytic Leukaemia. Cochrane Database of Systematic Reviews 2006, Issue 3. Art. No.: CD004270. DOI: 10.1002/14651858.CD004270.pub2

Steurer M, Pall G, Richards S, Schwarzer G, Bohlius J, Greil R. Single agent purine analogues for the treatment of chronic lymphocytic leukemia: a systematic review and meta-analysis. Cancer Treat Revs 2006; 32: 377-89

Tapia-Conyer R, Kuri-Morales P, Alegre-Diaz J, Whitlock G, Emberson J, Clark S, Peto R, Collins R. Cohort profile: The Mexico City Prospective Study. Int J Epidemiol 2006; 35: 243-9

Taylor CW, McGale P, Darby SC. Cardiac risks of breast-cancer radiotherapy: A contemporary view. Clinical Oncology 2006; 18, 236-46

Vora A, Mitchell CD, Lennard L, Eden TOB, Kinsey SE, Lilleyman J, Richards SM, on behalf of the MRC/NCRN Childhood Leukaemia Working Party.Toxicity and efficacy of thioguanine versus mercaptopurine in childhood lymphoblastic leukaemia: a randomised trial. Lancet 2006; 368: 1339-48

Williams C, Brunskill S, Altman D, Briggs A, Campbell H, Clarke M, Glanville J, Gray A, Harris A, Johnston K, Lodge M. Cost-effectiveness of using prognostic information to select women with breast cancer for adjuvant systemic therapy. Health Technology Assessment 2006; 10: 1-204

Wood A, White I, Thompson S, Lewington S, Danesh J on behalf of the Fibrinogen Studies Collaboration. Regression dilution methods for meta-analysis: assessing long-term variability in plasma fibrinogen among 27,247 adults in 15 prospective studies. Int J Epidemiol 2006; 35: 1570-8

Woodward M, Rumley A, Rumley A, Rumley C, Lewington S, Morrison C, Lowe G. The association between homocysteine and myocardial infarction is independent of age, sex, blood pressure, cholesterol, smoking and markers of inflammation: the Glasgow Myocardial Infarction Study. Blood Coagul Fibrinolysis 2006; 17: 1-5

Ye Z, Liu EH, Higgins JP, Keavney BD, Lowe GD, Collins R, Danesh J. Seven haemostatic gene polymorphisms in 64,155 cases and 91,307 controls. Lancet 2006; 367: 651-8

Publications in 2005

Baigent C, Landray M, Leaper C, Altmann P, Armitage J, Baxter A, Cairns HS, Collins R, Foley RN, Frighi V, Kourellias K, Ratcliffe PJ, Rogerson M, Scoble JE, Tomson CRV, Warwick G, Wheeler DC. First United Kingdom Heart and Renal Protection (UK-HARP-I) study: Biochemical efficacy and safety of simvastatin and safety of low-dose aspirin in chronic kidney disease. Am J Kid Dis 2005; 45: 473-84

Baigent C. For debate: Aspirin for everyone older than 50? Against. BMJ 2005; 330: 1442-3

Blood Pressure Lowering Treatment Trialists’ Collaboration (Baigent C, member of Secretariat). Effects of different blood-pressure-lowering regimens on major cardiovascular events in individuals with and without diabetes mellitus. Ann Intern Med 2005; 165: 1410-19

Cairns V, Godwin J. Post-Lyme borreliosis syndrome: a meta-analysis of reported symptoms. Int J Epidemiol 2005; 34: 1340-5

Campbell PJ, Scott LM, Buck G, Wheatley K, East CL, Marsden JT, Duffy A, Boyd EM, Bench AJ, Scott MA, Vassiliou GS, Milligan DW, Smith SR, Erber WN, Bareford D, Wilkins BS, Reilly JT, Harrison CN, Green AR. Definition of subtypes of essential thrombocythaemia and relation to polycythaemia vera based on JAK2 V617F mutation status: a prospective study. Lancet. 2005; 366: 1945-53

Chen ZM, Lee L, Chen J, Collins R, Wu F, Guo Y, Linksted P, Peto R. Cohort Profile: The Kadoorie study of chronic disease in China (KSCDC). Int J Epidemiol 2005; 34: 1243-49

Cholesterol Treatment Trialists’ (CTT) Collaborators (writing committee: Baigent C, Keech A, Kearney PM, Blackwell L, Buck G, Pollicino C, Kirby A, Sourjina T, Peto R, Collins R, Simes J). Efficacy and safety of cholesterol-lowering treatment: meta-analysis of individual data from 90,056 participants in 14 randomised trials of statins. Lancet 2005; 366: 1267-78

Clarke R. Homocysteine. In Stanner S (Editor), Cardiovascular Disease: Diet, Nutrition and Emerging Risk Factors. British Nutritional Foundation, London. Blackwell Scientific Publications 2005

Clarke R. Homocysteine-lowering trials for prevention of heart disease and stroke. Seminars in Vasc Med 2005; 5: 2215-22

Clarke R, Frost C, Sherliker P, Lewington S, Collins R, for the Homocysteine-Lowering Trialists’ Collaboration. Dose-dependent effects of folic acid on plasma homocysteine concentrations. A meta-analysis of the randomised trials. Am J Clin Nutr 2005; 82: 806-12

COMMIT collaborative group (writing committee: Chen ZM, Pan HC, Chen YP, Peto R and Collins R). Addition of clopidogrel to aspirin in 45,852 patients with acute myocardial infarction: randomised placebo-controlled trial. Lancet 2005; 366: 1607-21

COMMIT collaborative group (writing committee: Chen ZM, Pan HC, Chen YP, Peto R and Collins R). Early intravenous then oral metoprolol in 45,852 patients with acute myocardial infarction: randomised placebo-controlled trial. Lancet 2005; 366: 1622-32

CRASH trial collaborators (Baigent C, member of Steering Committee; Collins R, member of Data Monitoring Committee). Final results of CRASH, a randomised placebo-controlled trial of intravenous corticosteroid in adults with head injury—outcomes at 6 months. Lancet 2005; 365: 1957-59

Dahlöf B, Sever PS, Poulter NR, Wedel H, Beevers DG, Caulfield M, Collins R, Kjeldsen SE, Kristinsson A, McInnes GT, Mehlsen J, Nieminen M, O´Brien E, Östergren J, for the ASCOT investigators. Prevention of cardiovascular events with an antihypertensive regimen of amlodipine adding perindopril as required versus atenolol adding bendroflumethiazide as required, in the Anglo-Scandinavian Cardiac Outcomes Trial – Blood Pressure Lowering Arm (ASCOT-BPLA): a multicentre randomised controlled trial. Lancet 2005; 366: 895-906

Darby S, Davies C, McGale P. The Early Breast Cancer Trialists' Collaborative Group: a brief history of the results to date. In: Celebrating Statistics. Davidson AC, Dodge Y, Wermuth N (eds). Oxford University Press, Oxford 2005; pp185-96

Darby SC, Gilbert ES. (2005) Radiation. pp3662-3668 in: 'Encyclopedia of Biostatistics, 2nd Edition'. Armitage P, Colton T (eds) Wiley, Chichester UK

Darby S, Hill D, Auvinen A, Barros-Dios J M, Baysson H, Bochicchio F, Deo H, Falk R, Forastiere F, Hakama M, Heid I, Kreienbrock L, Kreuzer M, Lagarde F, Mäkeläinen I, Muirhead C, Oberaigner W, Pershagen G, Ruano-Ravina A, Ruosteenoja E, Schaffrath Rosario A, Tirmarche M, Tomášek L, Whitley E, Wichmann HE, Doll R. Radon in homes and risk of lung cancer: collaborative analysis of individual data from 13 European case-control studies. BMJ 2005; 330: 223-7

Darby S, McGale P, Taylor CW and Peto R. Long-term mortality from heart disease and lung cancer after radiotherapy for early breast cancer: prospective study of about 300 000 women in US SEER cancer registries. Lancet Oncol 2005; 6: 557-65

Den Heijer M, Lewington S, Clarke R. Homocysteine, MTHFR and risk of venous thrombosis: a meta-analysis of published epidemiological studies. J Thromb Haemost 2005; 2: 1-8

Doll R, Boreham J. Recent trends in cancer mortality in the UK. British Journal of Cancer 2005; 92: 1329-35

Doll R, Peto R, Boreham J, Sutherland I. Mortality in relation to alcohol consumption: a prospective study among male British doctors. Int J Epidem 2005; 34: 199-204

Doll R, Berrington A, Darby S. Low mortality of British radiologists. Br. J. Radiol 2005; 78: 1057-8

Early Breast Cancer Trialists' Collaborative Group (writing committee: Clarke M, Collins R, Darby S, Davies C, Evans V, Godwin J, Gray R, McGale P, Peto R, Wang Y). Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival: an overview of the randomised trials. Lancet 2005; 365: 1687-717

Early Breast Cancer Trialists’ Collaborative Group (writing committee: Clarke M, Collins R, Darby S, Davies C, Elphinstone P, Evans V, Godwin J, Gray R, Hicks C, James S, MacKinnon E, McGale P, McHugh T, Peto R, Taylor C, Wang Y). Effects of radiotherapy and of differences in the extent of surgery for early breast cancer on local recurrence and 15-year survival: an overview of the randomised trials. Lancet 2005: 366: 2087-106

Eussen SJPM, deGroot CPGM, Clarke R, Schneede J, Ueland PM, Hofnagels WHL, van Staveren WA. Oral vitamin B12 supplementation in elderly people with vitamin B12 deficiency: a dose-finding trial. Arch Intern Medicine 2005; 165: 1167-72

Fairbank J, Frost H, Wilson-MacDonald J, Yu L-M, Barker K, Collins R, for the Spine Stabilisation Trial Group. Randomised controlled trial to compare surgical stabilisation of the lumbar spine with an intensive rehabilitation programme for patients with chronic low back pain: the MRC Spine Stabilisation Trial. BMJ 2005; 330: 1233-39

Fibrinogen Studies Collaboration (writing committee: Danesh J, Lewington S, Thompson SG, Lowe DGO, Collins R). Plasma fibrinogen level and the risk of major cardiovascular diseases and nonvascular mortality: an individual participant meta-analysis. JAMA 2005; 294: 1799-809

Harrison CN, Campbell PJ, Buck G, Wheatley K, East CL, Bareford D, Wilkins BS, van der Walt JD, Reilly JT, Grigg AP, Revell P, Woodcock BE, Green AR. Hydroxyurea compared with anagrelide in high-risk essential thrombocythemia. New Engl J Med 2005; 353: 33-45

Heart Protection Study Collaborative Group (writing committee: Armitage J, Collins R, Bowman L, Parish S, Sleight P, Peto R). The effects of cholesterol-lowering with simvastatin on cause-specific mortality and on cancer incidence in 20,536 high-risk people: a randomised placebo-controlled trial. BMC Medicine 2005 3:6 (published 16 March)

Heart Protection Study Collaborative Group (writing committee: Mihaylova B, Briggs A, Armitage J, Parish S, Gray A, Collins R). Cost-effectiveness of simvastatin in people at different levels of cardiovascular disease risk: economic analysis of a randomised trial in 20,536 individuals. Lancet 2005; 365: 1779-85

Homocysteine Lowering Trialists’ Collaboration (writing committee: Clarke R, Frost C, Sherliker P, Lewington S, Collins R). Dose-dependent effects of folic acid on blood concentrations of homocysteine: a meta-analysis of the randomized trials. Am J Clin Nutr 2005; 82: 806-12

Kendall GM, Darby SC, Muirhead CR, Doll R. Reply to comment on papers on NRPB study of the UK test veterans. J Radiol Prot 2005; 25: 193-201

Kendall GM, Darby SC, Muirhead CR, Doll R. Reply to 'Comments on papers on NRPB study of the UK test veterans'. J Radiol Prot 2005; 25: 199-201

Lewington S, Clarke R. Combined effects of systolic blood pressure and total cholesterol on cardiovascular disease risk. Circulation 2005; 112: 3373-74

Martineau M, Jalali GR, Barber KE, Broadfield ZJ, Cheung KL, Greaves MF, Lilleyman J, Moorman AV, Richards S, Robinson HM, Ross F, Harrison CJ. ETV6/RUNX1 fusion at diagnosis and relapse: some prognostic implications. Genes, Chromosomes and Cancer 2005; 43: 54-71

Mbulaiteye SM, Katabira ET, Wabinga H, Parkin DM, Virgo P, Ochai R, Workneh M, Coutinho A, Engels EA.Spectrum of cancers among HIV-infected persons in Africa: The Uganda AIDS-Cancer Registry Match Study. Int J Cancer 2005; 118: 985-90

McGale P and Darby SC. Low doses of ionizing radiation and circulatory diseases: a systematic review of the published epidemiological evidence. Radiat Res 2005; 163: 247-57

McGhee SM, Ho SY, Schooling M, Ho LM, Thomas GN, Hedley AJ, Mak KH, Peto R, Lam TH. Mortality associated with passive smoking in Hong Kong. BMJ 2005; 330: 287–8

Melse-Boonstra A, Holm PA, Ueland PM, Olthof M, Clarke R, Verhoef P. Betaine as a determinant of fasting total homocysteine concentration and the effect of folic acid supplementation. Am J Clin Nutr 2005; 81: 1378-82

Mitchell CD, Richards SM, Kinsey SE, Lilleyman J, Vora A, Eden OB on behalf of the MRC Childhood Leukaemia Working Party. Benefit of dexamethasone compared with prednisolone for childhood acute lymphoblastic leukaemia: results of the UK Medical Research Council ALL97 randomized trial. Br J Haematol 2005; 129: 734-45

Morkbak AL, Mjerde R, Emmens K, Molloy A, Hvas AM, Schneede J, Clarke R, Scott JM, Ueland PM, Nexo E. Holotranscobalamin, measurement and clinical utility. Clin Chem Lab Med 2005; 43: 1058-64

Molyneux AJ, Kerr RSC, Yu LM, Clarke M, Sneade M, Yarnold JA, Sandercock for the International Subarachnoid Aneurysm Trial (ISAT) Collaborative Group. International subarachnoid aneurysm trial (ISAT) of neurosurgical clipping versus endovascular coiling in 2143 patients with ruptured intracranial aneurysms: a randomised comparison of effects on survival, dependency, seizures, rebleeding, subgroups and aneurysm occlusion. Lancet 2005; 366: 809-17

Parkin DM. The global health burden of infection-associated cancers in the year 2002. Int. J. Cancer 2005; 118: 3030-44

Patrono C, Rodríguez LAG, Landolfi R, Baigent C. Low-dose aspirin for the prevention and treatment of atherothrombosis. New Engl J Med 2005; 353: 2373-83

Peniket A, Wainscoat J, Side L, Daly S, Kusec R, Buck G, Wheatley K, Walker H, Chatters S, Harrison C, Boultwood J, Goldstone A, Burnett A. Del (9q) AML: clinical and cytological characteristics and prognostic implications. Br J Haematol. 2005; 129: 210-20

Peto R. Nature, nurture and luck: Richard Peto celebrates Richard Doll, who made sense of the causes of cancer. Oxford Today, 2005; vol. 18(1):13

Peto R. Past and future tobacco mortality. In: Understanding Nicotine and Tobacco Addiction. Novartis Foundation Symposium 275. 2005

Peto R. Richard Doll, 1912-2005: half a century of cancer epidemiology. Cancer Research UK Scientific Yearbook 2004/5, pp.6-9

Richards S. Commentary on Fludarabine increases complete response but not survival compared with conventional alkylator-based regimens for previously untreated chronic lymphocytic leukaemia. Cancer Treatment Reviews 2005; 334-5

Roderick PJ, Ferris G, Wilson K, Halls H, Jackson D, Collins R. Baigent C Towards evidence-based guidelines for the prevention of venous thromboembolism: systematic reviews of mechanical methods, oral anticoagulation, dextran and regional anaesthesia as thromboprophylaxis. HTA reviews 2005 Health Technol Assess 2005; 9 (49)

Rowe JM, Buck G, Burnett AK, Chopra R, Wiernik PH, Richards SM, Lazarus HM, Franklin IM, Litzow MR, Prentice HG, Durrant J, Tallman MS, Goldstone AH. Induction therapy for adults with acute lymphoblastic leukemia (ALL): Results of over 1,500 patients from the international ALL trial: MRC UKALL XII / ECOG E2993. Blood 2005; 106: 3760-67

Sadjadi A, Nouraie M, Mohagheghi MA, Mousavi-Jarrahi A, Malekezadeh R, Parkin DM. Cancer occurrence in Iran in 2002, an international perspective. Asian Pac J Cancer Prev. 2005 Jul-Sep; 6: 359-63

Sasse EC, Sasse AD, Brandalise SR, Clark OAC, Richards S. Colony stimulating factors for prevention of myelosuppressive therapy induced febrile neutropenia in children with acute lymphoblastic leukaemia. Cochrane Database of Systematic Reviews 2005, Issue 4. Art. No.: CD004139. DOI: 10.1002/14651858.CD004139

Sever PS, Poulter NR, Dahlöf B, Wedel H, Beevers G, Caulfield M, Collins R, Kjeldsen SE, Kristinsson A, McInnes GT, Mehlsen J, Nieminen M, O'Brien E, Ostergren J, for the ASCOT investigators. The Anglo-Scandinavian Cardiac Outcomes Trial-Lipid-Lowering Arm (ASCOT-LLA): Reduction in cardiovascular events with atorvastatin in 2,532 patients with type 2 diabetes. Diabetes Care 2005; 28:1151-57

Sriamporn S, Kritpetcharat O, Nieminen P, Suwanrungraung K, Kamsa-ard S, Parkin DM. Consistency of cytology diagnosis for cervical cancer between two laboratories. Asian Pac J Cancer Prev 2005; 6: 208-12

Sriamporn S, Parkin DM, Pisani P, Vatanasapt V, Suwanrungruang K, Kamsa-Ard S, Pengsaa P, Kritpetcharat O, Pipitgool V, Vatanasapt P. A prospective study of diet, lifestyle, and genetic factors and the risk of cancer in Khon Kaen province, northeast Thailand: description of the cohort. Asian Pac J Cancer Prev 2005; 6: 295-303

Stem Cell Trialists’ Collaborative Group (Clarke M, Richards S). Allogenic peripheral blood stem cell vs. bone marrow transplantation in the management of haematological malignancies: an individual patient data meta-analysis of 9 randomized trials and 1,111 patients. J Clin Oncol 2005; 23: 5074-87

Taylor CW, Dodwell D. Oncological aspects of breast reconstruction. Breast 2005; 14: 118-30

Taylor CW, Kumar S. The effect of immediate breast reconstruction on adjuvant chemotherapy. Breast 2005; 14: 18-21

Taylor CW, Taylor RET, Kinsey SEK Leukemic infiltration of the orbit: Report of three cases and literature review. Pediatr Hematol Oncol 2005; 22: 415-2

Publications in 2004

Advisory Group on Non-ionising Radiation (Chairman: Swerdlow A, Doll R [until 31/3/03]; Members: Blakemore C, Challis L, Coggon D, Coulton L, Darby S [from 1/6/03], Haggard P [from 24/10/02], Noble D [23/6/03], Rugg M [until 28/2/03]) (2004). Particle Deposition in the Vicinity of Power Lines and Possible Effects on Health. Documents of the NRPB 2004; Volume 15 No 1

Armitage J, Bowman L. Cardiovascular outcomes among participants with diabetes in the recent large statin trials. Curr Opin Lipidol 2004; 15: 439-46

Baigent C, Landray M, Warren M. Statin therapy in kidney disease populations: potential benefits beyond lipid lowering and the need for clinical trials. Curr Opin Nephrol Hypertens 2004; 13: 601-5

Baigent C. The Struggle for Life: A Psychological perspective of kidney disease and transplantation. (Book Review). Am J Kid Dis 2004; 44: 382

Berrington de González A, Darby S. Risk of cancer from diagnostic X-rays: estimates for the UK and 14 other countries Lancet 2004; 363: 345-51

Berrington de González A, Darby S (2004) Risk of cancer from diagnostic X-rays. Lancet 363, 1910

Brennan PJ, Buffler PA, Reynolds P, Wu AH, Wichmann HE, Agudo A, Pershagen G, Jöckel KH, Benhamou S, Greenberg RS, Merletti F, Winck C, Fontham ETH, Kreuzer M, Darby SC, Forastiere F, Simonato L, Boffetta P. Secondhand smoke exposure in adulthood and risk of lung cancer among never-smokers. A pooled analysis of two large studies. International Journal of Cancer 2004; 109: 125-31

Chalmers I, Clarke M. Commentary: The 1944 patulin trial: the first properly controlled multicentre trial conducted under the aegis of the British Medical Research Council. International Journal of Epidemiology 2004; 32: 253-60

Chen ZM. Strategies for Tobacco Control. In: XU GW (ed). Cancer. Tianjin Health Publishing House, Tianjin, China, 2004

Clark S, Youngman LD, Chukwurah B, Palmer A, Parish S, Peto R, Collins R. Effect of temperature and light on the stability of fat-soluble vitamins in whole blood over several days: implications for epidemiological studies. Int J Epidemiol 2004; 33: 1-8

Clarke M, Neilson J. From the Co-Chairs. Cochrane News 2004; 30: 2

Clarke M. National provisions to The Cochrane Library: a personal view. Cochrane News 2004; 30: 1-6

Clarke M. The 1944 patulin trial of the British Medical Research Council: an example of how concerted common purpose can get reliable answers to important questions very quickly. [Online] Available from: The James Lind Library (www.jameslindlibrary.org). [May, 2004]

Clarke R, Grimley Evans J, Refsum H et al. Vitamin B12 and folate deficiency in older people. Age and Aging 2004; 33: 34-41

Collaborative Group on Hormonal Factors in Breast Cancer (writing committee: Beral V, Bull D, Doll R, Peto R, Reeves G) Breast cancer and abortion: collaborative reanalysis of data from 53 epidemiological studies, including 83 000 women with breast cancer from 16 countries. Lancet 2004; 363: 1007-16

Committee Examining Radiation Risks of Internal Emitters (CERRIE) (Chairman: Goodhead D; Members: Bramhall R, Busby C, Cox R, Darby S, Day P, Harrison J, Muirhead C, Roche P, Simmons J, Wakeford R, Wright E) (2004). Report of the Committee Examining Radiation Risks of Internal Emitters. Crown Copyright 2004.

CRASH trial collaborators. (Baigent C, member of Steering Committee) Effect of intravenous corticosteroids on death within 14 days in 10,008 adults with clinically significant head injury (MRC CRASH trial): randomised placebo-controlled trial. Lancet 2004; 364: 1321-28

Crispo A, Brennan P, Jöckel K-H, Schaffrath-Rosario A, Wichmann H-E, Nyberg F, Simonato L, Merletti F, Forastiere F, Boffetta P, Darby S. The cumulative risk of lung cancer among current, ex- and never-smokers in European men. Brit J Cancer 2004; 91: 1280-86

Davies C. Commentary on “Switching to exemestane after 2-3 years of adjuvant tamoxifen prolongs disease-free survival, but not overall survival, in postmenopausal women surviving primary breast cancer, compared with continuous tamoxifen [Coombes et al.  New Engl J Med 2004; 350: 1081]”. Cancer Treatment Reviews: Evidence Based Oncology 2004; 30: 583-8

Devane D, Begley CM, Clarke M. How many do I need? Basic principles of sample size estimation. Journal of Advanced Nursing 2004; 47: 297-302

Doll R Evolution of knowledge of the smoking epidemic. In: Tobacco: science, policy and public health. pp.1-16. Boyle P, Gray N, Henningfield J, Seffrin J, Zatonski W. (eds). Oxford University Press, Oxford, 2004

Doll R, Peto R, Boreham J, Sutherland I. Mortality in relation to smoking: 50 years' observations on male British doctors. BMJ 2004; 328: 1519-28

Gajalakshmi V, Peto R. Verbal autopsy of 80,000 adult deaths in Tamilnadu, South India. BMC Public Health 2004; 4: 47

Hanneke C Kluin-Nelemans, Georgina Buck, Saskia le Cessie, Sue Richards, H Berna Beverloo, J H Frederik Falkenburg, Tim Littlewood, Petra Muus, David Bareford, Hans van der Lelie, Anthony R Green, Klaas J Roozendaal, Alison E Milne, Claire S Chapman, and Patricia Shepherd. Randomized comparison of low dose versus high dose interferon-alfa in chronic myeloid leukaemia: Prospective collaboration of three joint trials by the MRC and HOVON groups Blood 2004; 103: 4408-15

Harrison CJ, Moorman AV, Broadfield ZJ, Cheung KL, Harris RL, Jalali GR, Robinson HM, Barber KE, Richards SM, Mitchell CD, Eden OB, Hann IM, Hill FGH, Kinsey SE, Gibson BES, Lilleyman J, Vora A, Goldstone AH, Franklin IM, Durrant J, Martineau M on behalf of the Childhood and Adult Leukaemia Working Parties. Three distinct subgroups of hypodiploidy in acute lymphoblastic leukaemia. Br J Haematol 2004; 125: 552-9

Heart Protection Collaborative Group (writing committee: Collins R, Armitage J, Parish S, Sleight P, Peto R). Effects of cholesterol-lowering with simvastatin on stroke and other major vascular events in 20,536 people with cerebrovascular disease or other high-risk conditions. Lancet 2004; 363: 757-67

Heerema NA, Harbott J, Galimberti S, Camitta BM, Gaynon PS, Janka-Schaub G, Kamps W, Basso G, Pui C-H, Schrappe M, Auclerc M-F, Caroll AJ, Conter V, Harrison CJ, Pullen J, Raimondi SC, Richards S, Riehm H, Sather HN, Shuster J, Silverman L, Valsecchi MG, Arico M. for the Acute Lymphoblastic Leukaemia Study Groups: ALL-BFM and CoALL (Germany), AIEOP (Italy), DCLSG (Netherlands), FRALLE (France), CCG, DFCI, POG and St.Jude (USA), and UKALL (UK). Secondary cytogenetic aberrations in childhood philadelphia chromosome positive acute lymphoblastic leukaemia are non-random and may be associated with outcome. Leukaemia 2004; 18: 693-702

Hill FGH, Richards S, Gibson B, Hann I, Lilleymann J, Kinsey S, Mitchell C, Harrison G, Eden OB, on behalf of the UK MRC Working Party on Childhood Leukaemia. Successful treatment without cranial radiotherapy of children receiving intensified chemotherapy for acute lymphoblastic leukaemia: results for the risk stratified randomized CNS treatment trial MRC UKALLXI. Br J Haematol 2004; 124: 33-46

Hopewell S, Clarke M, editors. The Cochrane Collaboration Methods Groups Newsletter 2004; 8: 1-39

Huxley R, Owen CG, Whincup PH, Cook DG, Colman S, Collins R. Birth weight and subsequent cholesterol levels: exploration of the "Fetal Origins" hypothesis. JAMA 2004; 292: 2755-64

International Artemisinin Study Group (CTSU chair of Advisory Group) Artesunate combinations for treatment of malaria: meta-analysis. Lancet 2004; 363: 9-17

Keavney B, Palmer A, Parish S, Clark S, Youngman L, Danesh J, McKenzie C, Delépine M, Lathrop M, Peto R, Collins R, for the International Studies of Infarct Survival (ISIS) Collaborators. Lipid-related genes and myocardial infarction in 4685 cases and 3460 controls: discrepancies between genotype, blood lipid concentrations and coronary disease risk. Int J Epidemiol 2004; 33: 1-12

Kendall GM, Muirhead CR, Darby SC, Doll R, Arnold L, O'Hagan JA. Epidemiological studies of UK test veterans: I. General description. J. Radiol Prot 2004; 24: 199-217

Kinlen J, Doll R Population mixing and childhood: leukaemia: Fallon and other US clusters. Editorial. Brit J Cancer 2004; 91: 1-3

Kumar A, Soares HP, Wells RJ, Khayat A, Clarke M, Hills RK, Bleyer A, Reaman G, Djulbegovic B. Experimental vs. control interventions in cancer therapy: which is better? - The Children's Oncology Group Experience. Abstract 6016. J Clin Oncol 2004; 22(Suppl 14S): 523s

Landray M, Wheeler D, Lip G, Newman D, Blann A, McGlynn F, Ball S, Townend J, Baigent C. Inflammation, endothelial dysfunction and platelet activation in patients with chronic kidney disease: The Chronic Renal Impairment in Birmingham (CRIB) Study. Am J Kidney Dis 2004; 43: 244-53

Langford NJ, Landray M, Martin U, Kendall MJ, Ferner RE. Testing the practical aspects of therapeutics by objective structured clinical examination. J Clin Pharm Ther 2004; 29: 263-6

Lawes CMM, Parag V, Bennett DA, Suh I, Lam TH, Whitlock G, Barzi F, Pan WH, Rodgers A. Blood glucose and risk of cardiovascular disease in the Asia Pacific region. Diabetes Care 2004; 27: 2836-42

Lowe GD, Danesh J, Lewington S, Walker M, Lennon L, Thomson A, Rumley A, Whincup PH. Tissue plasminogen activator antigen and coronary heart disease. Prospective study and meta-analysis. Eur Heart J 2004; 25: 252-9

Mills E, Montori VM, Wu P, Gallicano K, Clarke M, Guyatt G. Interaction of St John's Wort with conventional drugs: systematic review of clinical trials. BMJ 2004; 329: 27-30

MRC Asymptomatic Carotid Surgery Trial (ACST) Collaborative Group (writing committee: Halliday A, Mansfield A, Marro J, Peto C, Peto R, Potter J, Thomas D) Prevention of disabling and fatal strokes by successful carotid endarterectomy in patients without recent neurological symptoms: randomised controlled trial. Lancet 2004; 363: 1491-1502

Muirhead GM, Kendall GM, Darby SC, Doll R, Haylock RGE, O'Hagan JA, Berridge GLC, Phillipson MA, Hunter N. Epidemiological studies of UK test veterans: I. Mortality and cancer incidence. J. Radiol Prot. 2004; 24: 219-41

Patel A, Barzi F, Jamrozik K, Lam TH, Lawes C, Ueshima H, Whitlock G, Woodward M. Serum triglycerides as a risk factor cardiovascular diseases in the Asia Pacific region. Circulation 2004; 110: 2678-86

Peto R. Foreword. In: Ezzati M, Lopez AD, Rodgers A, Murray CJL (eds) Comparative Quantification of Health Risks: Global and regional burden of disease attributable to selected major risk factors. vol.1. World Health Organisation, Geneva

Peto R (working group member). General remarks: future worldwide health effects of current smoking patterns. Pages 33-47. In: IARC Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans. Volume 83: Tobacco smoke and involuntary smoking. IARC, Lyon, 2004

Peto R, Lopez AD. The future worldwide health effects of current smoking patterns. In: Boyle P, Gray N, Henningfield J, Seffrin J, Zatonski W (eds). Tobacco and Public Health: Science and Policy. pp.281-6. Oxford: Oxford University Press, 2004

PROCARDIS CONSORTIUM (principal investigators: Watkins H, Collins R, Tognoni G, Hansten A, Assmann G): A trio family study showing association of the lymphotoxin-a N26 (804A) allele with coronary artery disease. Eur J Hum Genetics 2004; 12: 770-4

Refsum H, Smith AD, Ueland PM, Nexo E, Clarke R, McPartlin J, Johnston C, Engbaek F, Schneede J, McPartlin C and Scott JM. Facts and recommendations about total homocysteine determinations: an expert opinion. Clin Chem 2004; 50: 30-2

Saving lives, buying time: economics of antimalarial drugs in an age of resistance (Arrow KJ, Panosian CB, Gelbald H, eds). Committee on the Economics of antimalarial drugs (Arrow KJ, Bloland PB, Danzon PM, Greenwood BM, Jamison DT, Kindermans J-M, Laxminarayan R, Mills AJ, Mshinda H, Mwabu G, Peto R, Ridley RG, White NJ) 2004: National Academies Press, Washington DC

Scott RB, Farmer E, Smiton A, Tovey C, Clarke M, Carpenter K. Methodology of neuropsychological research in multicentre randomized clinical trials: a model derived from The International Subarachnoid Aneurysm Trial. Clinical Trials 2004; 1: 31-9

Sitas F, Urban M, Bradshaw D, Kielkowski D, Bah S, Peto R. Tobacco attributable deaths in South Africa. Tobacco Control 2004; 13: 396-9

Soares HP, Daniels S, Kumar A, Clarke M, Scott C, Swann S, Djulbegovic B. Bad reporting does not mean bad methods for randomized trials: observational study of randomised controlled trials performed by the Radiation Therapy Oncology Group. BMJ 2004; 328: 22-5

Stewart L, Tierney J, Clarke M. Cochrane Individual Patient Data Meta-analysis Methods Group. Cochrane Collaboration Methods Groups Newsletter 2004; 8: 27-8

The Task Force on the use of antiplatelet agents in patients with atherosclerotic cardiovascular disease of the European Society of cardiology. (Baigent C, member of writing committee) Expert Consensus Document on the use of antiplatelet agents. Eur Heart J 2004; 25: 166-81

UK Haemophilia Centre Doctors' Organisation (Analysis & Writing Committee: Darby SC, Kan SW, Spooner RJD, Giangrande PLF, Lee CA, Makris M, Sabin CA, Watson HG, Wilde JT, Winter M). The impact of HIV on Mortality Rates in the Complete UK Haemophilia Population. AIDS 2004; 18: 525-33

UK Haemophilia Centre Doctors' Organisation (Analysis & Writing Committee: Darby SC, Keeling DM, Spooner RJ, Kan SW, Giangrande PLF, Collins PW, Hill FGH, Hay, CRM). The incidence of factor VIII and factor IX inhibitors in the hemophilia population of the UK and their effect on subsequent mortality. J Thromb Haemost 2004; 2: 1044-6

Vineis P, Alavanja M, Buffler P, Fontham E, Franceschi S, Gao YT, Gupta PC, Hackshaw A, Matos E, Samet J, Sitas F, Smith J, Stayner L, Straif K, Thun MJ, Wichmann HE, Wu AH, Zaridze D, Peto R, Doll R. Tobacco and Cancer: Recent Epidemiological Evidence. J Natl Cancer Inst 2004; 96: 99-106

Westby M, Clarke M Hopewell S Ram F. Masking reviewers at the study inclusion stage in a systematic review of healthcare interventions (Protocol for a Cochrane Methodology Review). In: Cochrane Library, Issue 2, 2004. Chichester, UK: John Wiley & Sons, Ltd

Wheeler JG, Keavney B, Watkins H, Collins R, Danesh J. Four paraoxonase gene polymorphisms in 11000 cases of coronary heart disease and 13000 controls: meta-analysis of 43 studies. Lancet 2004; 363: 689-95

Whitlock G, Norton R, Clark T, Jackson R, MacMahon S. Motor vehicle driver injury and marital status: a cohort study with prospective and retrospective injuries. Injury Prevention 2004; 10: 33-6

Publications in 2003

Advisory Group on Non-ionising Radiation (Chairman: Swerdlow A, Doll R [until 31/3/03]; Members: Blakemore C, Challis L, Coggon D, Coulton L, Darby S [from 1/6/03], Haggard P [from 24/10/02], Noble D [23/6/03], Rugg M [until 28/2/03]) (2003). Health Effects from Radiofrequency Electromagnetic Fields. Documents of the NRPB 2003; Volume 14 No 2

Armitage J. Cholesterol lowering for the prevention of stroke. Practical neurology 2003; 3: 225-33

Baigent C, Patrono C. Selective Cyclooxygenase 2 inhibitors, aspirin and cardiovascular disease. A reappraisal. Arthritis and Rheumatism 2003; 48: 12-20

Baigent C, Landray M. Study of Heart and Renal Protection (SHARP). Kidney International 2003; 63, Suppl.84: 207-10

Blood Pressure Lowering Treatment Trialists’ Collaboration (Baigent C, member of Secretariat). Effect of different blood-pressure-lowering regimens on major cardiovascular events: results of prospectively-designed overview of randomized trials. Lance 2003; 362: 1527-35

Brenner J, Doll R, Goodhead TD, Hall EJ, Little JB, Lubin JH, Preston DL, Preston RJ, Pushin JS, Ron E, Sachs RK, Samet JM, Setlow RB, Zaider M. Cancer risks attributable to low doses of ionizing radiation: assessing what we really know. Proc Natl Acad Sci 2003, 100: 13761-6

Chen ZM, Liu BQ, Boreham J, Wu JP, Chen JS, Peto R. Smoking and liver cancer in China: case-control comparison of 36,000 liver cancer deaths vs. 17,000 cirrhosis deaths. Int J Cancer 2003; 107: 106-12

Childhood ALL Collaborative Group (writing committee: Clarke M, Gaynon P, Hann I, Harrison G, Masera G, Peto R, Richards S): CNS-directed therapy for childhood acute lymphoblastic leukaemia: Childhood ALL Collaborative Group overview of 43 randomized trials. J Clin Oncol 2003; 21:1798-809

Clark S, Youngman LD, Palmer A, Parish S, Peto R, Collins R. Stability of plasma analytes after delayed separation of whole blood: implications for epidemiological studies. Int J Epidemiology 2003; 32: 125-30

Clark S, Youngman LD, Sullivan J, Peto R, Collins R. Stabilization of homocysteine in unseparated blood over several days: a solution for epidemiological studies. Clin Chem 2003; 49: 518-20

Clarke M, Fischer M, Hopewell S, Juszczak E, Eisinga A. Compression stockings for preventing deep vein thrombosis in airline passengers (Protocol for a Cochrane Review). In: Cochrane Library, Issue 1, 2003. Oxford: Update Software

Clarke M. The Early Breast Cancer Trialists' Collaborative Group: systematic reviews of treatments for women with breast cancer. In: Perry MC, editor. American Society of Clinical Oncology Educational Book. 39th Annual Meeting of the American Society of Clinical Oncology; 2003 May 31-June 3; Chicago (IL). Alexandria (VA). American Society of Clinical Oncology. 2003:751-8

Clarke R, Armitage J. Symposium: Vitamins and risk of cardiovascular disease review of large-scale randomised trials Vitamin supplements and cardiovascular risk: Review of the randomized trials. Cardiovasc drugs and Therapy 2003; 16: 411-5

Clarke R, Harrison G, Richards S, for the VITAL Trial Collaborative Group. Effect of vitamins and aspirin treatment on markers of platelet activation, oxidative stress and homocysteine in people with dementia. J Internal Medicine 2003; 254:67-75.

Clarke R, Lewington S, Landray M. Homocysteine, renal function and risk of cardiovascular disease. Kidney International 2003; 84: 5131-3

Clarke R, Lewington S. How important are elevated homocysteine levels and the MTHFR C677T→T genotype for coronary artery disease? Harrison’s Textbook of Medicine 2003; Online

Clarke R, Refsum H, Birks J, Grimley Evans J, Johnston C, Sherliker P, Ueland PM, Schneede J, McPartlin J, Nexo E, Scott JM. Screening for vitamin B12 and folate deficiency in older persons. Am J Clin Nutr 2003; 77: 1241-47

Collins R, Peto R, Gray R, Parish S. Large-scale randomized evidence: trials and overviews. In: Oxford Textbook of Medicine, 4th edition. Warrell DA, Cox TM, Firth JD, Benz EJ (eds). Oxford: Oxford University Press, 2003

Cox DR, Darby SC (guest associate editors) (2003). The Communication of Risk. Journal of the Royal Statistical Society, Series A, 166, 203-70

Cuervo LG, Clarke M. Balancing benefits and harms in health care: we need to get better evidence about harms. BMJ 2003; 327: 65-6

Darby S, McGale P, Peto R, Granath F, Hall P, Ekbom A,. Mortality from cardiovascular disease more than 10 years after radiotherapy for breast cancer: nationwide cohort study of 90,000 Swedish women. BMJ 2003; 326: 256-7

Darby SC. Voices: A Conversation with Sir Richard Doll. Epidemiology 2003; 14: 375-9

Darby SC, Hill DC on behalf of the European Collaborative Group on Residential Radon and Lung Cancer. Health effects of residential radon: a European perspective at the end of 2002. Radiation Protection Dosimetry 2003; 104: 321-9

Darby SC. Tobacco - the importance of relevant information on risk. Journal of the Royal Statistical Society Series A 2003;166: 225-31

den Heijer T, Vermeer S, Clarke R, Oudkerk M, Koudstaal PJ, Hofman A, Breteler MMB. Homocysteine, medial temporal lobe and generalised brain atrophy on MRI of non-demented elderly. Brain 2003; 126: 170-5

Djulbegovic B, Cantor A, Clarke M. The importance of the preservation of the ethical principle of equipoise in the design of clinical trials: relative impact of the methodological quality domains on the treatment effect in randomized controlled trials. Accountability in Research 2003; 10: 301-15

Doll R. Fisher and Bradford Hill: Their personal impact. Int J Epidemiol 2003; 32: 929-31

Doll R. The evolution of the controlled trial. Our Lords, The Sick McGovern Lectures on the History of Medicine and Medical Humanism. Longo D. (ed). FL Publishing, Melbourne, 2003

Gajalakshmi V, Peto R, Kanaka TS, Jha P. Smoking and mortality from tuberculosis and other diseases in India: retrospective study of 43,000 adult male deaths and 35,000 controls. Lancet 2003; 362: 507-15

Gajalakshmi V, Peto R. Verbal autopsy to evaluate completeness of cancer registration in Chennai, India. J Registry Management 2003; 30: 4-7

Harewood L, Robinson H, Harris R, Al-Obaidi MJ, Jalali GR, Martineau M, Moorman AV, Sumption N, Richards S, Mitchell C, Harrison C. Amplification of AML1 on a duplicated chromosome 21 in acute lymphoblastic leukemia. A study of 20 cases. Leukemia 2003; 17: 547-53

Heart Protection Study Collaborative Group (writing committee: Collins R, Armitage J, Parish S, Sleight P, Peto R). MRC/BHF Heart Protection Study of cholesterol-lowering with simvastatin in 5963 people with diabetes: a randomised placebo-controlled trial. Lancet 2003; 361: 2005-16

Hills RK, Richards SM, Wheatley K. Corner cutting compromises clinical trials: the inherent problems with up-front randomisation and a common standard arm. Leukaemia Research 2003; 27: 1071-73

Homewood J, Watson M, Richards SM, Halsey J, Shepherd PCA on behalf of the Adult Leukaemia Working Party. Treatment of CML using IFN-α: impact on quality of life. The Hematology Journal 2003; 4: 253-62

Hopewell S, Clarke M, Lefebvre C, Scherer R. Handsearching versus electronic searching to identify reports of randomized trials (Cochrane Methodology Review). In: Cochrane Library, Issue 2, 2003. Oxford: Update Software

Hopewell S, McDonald S, Clarke M. Grey literature in meta-analyses of randomized trials of health care interventions (Cochrane Methodology Review). In: Cochrane Library, Issue 1, 2003. Oxford, Update Software

Keavney B, Parish S, Palmer A, Clark S, Youngman L, Danesh J, McKenzie C, Delépine M, Lathrop M, Peto R, Collins R, for the International Studies of Infarct Survival (ISIS) Collaborators. Large-scale evidence that the cardiotoxicity of smoking is not significantly modified by the apolipoprotein E e2/e3/e4 genotype. Lancet 2003; 361: 396-8

Lewington S, Thomsen T, Davidsen M, Clarke R. Regression dilution bias in blood pressure and blood lipids in the Glostrup cohort and Framingham studies J Cardiovasc Risk 2003; 10: 143-8

Mallett S, Clarke M. How many Cochrane reviews are needed to cover existing evidence on the effects of healthcare interventions? Evidence Based Medicine 2003; 8: 100-1

Moorman A,V, Richards SM, Martineau M, Cheung KL, Robinson HM, Jalali GR, Broadfield ZJ, Harris RL, Taylor KE, Gibson B, Hann I, Hill F, Kinsey S, Eden OB, Mitchell C, Harrison CJ on behalf of the UK Medical Research Council’s Working Party on Childhood Leukaemia. Outcome heterogeneity in childhood high hyperdiploid acute lymphoblastic leukaemia. Blood 2003; 102: 2756-62

Morris EC, Harrison G, Bailey CC, Hann IM, Hill FG, Gibson BES, Richards S, Webb D for the MRC childhood leukaemia Working Party. Prognostic factors and outcome for children after second central nervous system relapse of acute lymphoblastic leukaemia. Br J Haematol 2003; 120: 787-9

Peto R, Baigent C. Need for large-scale randomized evidence to assess moderate benefits reliably. In: Nabholtz J-M, Aapro M, Tonkin K, Buzdar A U, Reese D M (eds) Application of clinical and translational evidence to patient care. Lippincott Williams and Wilkins, Philadelphia, 2003

Pui C-H, Chessells JM, Camitta B, Baruchel A, Biondi A, Boyett JM, Carroll A, Eden OB, Evans WE, Gadner H, Harbott J, Harms DO, Harrison C, Harrison P, Heerema N, Janka-Schaub G, Kamps W, Masera G, Pullen J, Raimondi S, Richards S, Riehm H, Sallan S, Sather H, Shuster J, Silverman LB, Valsecchi MG, Vilmer E, Zhou Y, Gaynon PS, Schrappe M. Clinical heterogeneity in childhood acute lymphoblastic leukemia with 11q23 rearrangements. Leukemia 2003; 17: 700-6

Schaeffner ES, Kurth T, Curhan GC, Glynn RG, Rexrode KM, Baigent C, Buring JE, Gaziano JM. Cholesterol and the risk of renal dysfunction in apparently healthy men. J Am Soc Nephrol 2003; 14: 2084-91

Sever PS, Dahlöf B, Poulter NR, Wedel H, Beevers G, Caulfield M, Collins R, Kjeldsen SE, Kristinsson A, McInnes GT, Mehlsen J, Nieminen M, O'Brien E, Östergren J, for the ASCOT investigators. Prevention of coronary and stroke events with atorvastatin in hypertensive patients who have average or lower-than-average cholesterol concentrations, in the Anglo-Scandinavian Cardiac Outcomes Trial — Lipid Lowering Arm (ASCOT-LLA): a multicentre randomised controlled trial. Lancet 2003; 361: 1149-58

Taylor CW, Kumar S. The effect of immediate breast reconstruction on adjuvant chemotherapy. Eur J Cancer 2003; 1: 41

Trivedi DP, Doll R, Khaw KT. Effect of four months oral vitamin D, cholecalciferol supplementation on fractures and mortality on men and women living in the community: randomised double-blind controlled trial. BMJ 2003; 326: 469-72

van Oort FVA, Boonstra AM, Brouwer I, Clarke R, West CE, Katan MB, Verhoef P. Folic acid and plasma homocysteine reduction in older adults: a dose-finding study. Am J Clin Nutr 2003; 77:1318-23

Wheeler DC, Townend JN, Landray MJ. Cardiovascular risk factors in pre-dialysis patients: Baseline data from the Chronic Renal Impairment in Birmingham (CRIB) study. Kidney Int 2003; 63(Suppl84): 201-3

Publications in 2002

Antithrombotic Trialists' (ATT) Collaboration (writing committee: C Baigent, C Sudlow, R Collins, R Peto). Collaborative meta-analysis of randomised trials of antiplatelet therapy for prevention of death, myocardial infarction, and stroke in high-risk patients. BMJ 2002; 324: 71-86

Blann AD, Landray MJ, Lip GYH. ABC of antithrombotic therapy. An overview of antithrombotic therapy. BMJ 2002; 325: 762-5

Bonnici F, Keavney B, Collins R, Danesh J. Angiotensin converting enzyme insertion or deletion polymorphism and coronary restenosis: meta-analysis of 16 studies. BMJ 2002; 325: 517-9

Bowman LJ, Armitage JM. Diabetes and impaired glucose tolerance: a review of the epidemiological and trial evidence for their role in cardiovascular risk. Seminars in Vascular Medicine 2002;2(4):383-9

Chen ZM & Boreham J. Smoking and cardiovascular disease. Seminar in Vascular Medicine 2002; 2: 233-42

Chessells JM, Harrison CJ, Watson SL, Vora AJ, Richards SM. Treatment of infants with lymphoblastic leukaemia: results of the UK Infant Protocols 1987-1999. Br J Haematol 2002; 117: 306-14

Chessells JM, Harrison G, Richards SM, Gibson BE, Bailey CC, Hill FGH, Hann IM for the Medical Research Council Working Party on childhood leukaemia. Failure of new protocol to improve treatment results in paediatric lymphoblastic leukaemia: lessons from the UK Medical Research Council trials UKALLX and UKALLXI. Br J Haematol 2002; 118: 445-55

Clarke M, Alderson P, Chalmers I. Discussion sections in reports of controlled trials published in general medical journals. JAMA 2002; 287: 2799-801

Clarke M. Searching for trials for systematic reviews: what difference does it make? Int J Epidemiol 2002; 31: 123-4

Clarke M. The Cochrane Collaboration: Providing, and obtaining, the best evidence about the effects of health care. Evaluation and the Health Professions 2002; 25: 8-11

Clarke R, Armitage J. Anti-oxidant vitamins and risk of cardiovascular disease, Review of large-scale randomised trials. Cardiovasc Drugs Ther 2002; 16: 411-5

Clarke R, Commentary: An updated review of the published studies of homocysteine and cardiovascular disease. Int J Epidemiol 2002; 31: 70-1

Clarke R, Lewington L, Youngman L, Sherliker P, Peto P, Collins R. Underestimation of the importance of blood pressure and cholesterol for coronary heart disease mortality in old age. Eur Heart J 2002; 23: 286-93

Clarke R, Lewington S, Donald A and Collins R for the Homocysteine Studies Collaboration. Homocysteine and risk of ischemic heart disease and stroke. 6000 events in 30 observational studies. JAMA 2002; 288: 2015-22

Clarke R, Lewington S. Homocysteine and risk of heart disease and stroke. Seminars in Vascular Medicine 2002; 3: 391-9

Collaborative Group on Hormonal Factors in Breast Cancer (writing committee: Beral V, Bull D, Doll R, Peto R, Reeves G). Breast cancer and breastfeeding: collaborative reanalysis of individual data from 47 epidemiological studies in 30 countries, including 50 302 women with breast cancer and 96 973 women without the disease. Lancet 2002; 360: 187-95

Collaborative Group on Hormonal Factors in Breast Cancer (writing committee: Beral V, Bull D, Doll R, Peto R, Reeves G). Alcohol, tobacco and breast cancer — collaborative reanalysis of individual data from 53 epidemiological studies, including 58,515 women with breast cancer and 95,067 women without the disease. Br J Cancer 2002; 87: 1234-45

Collins R, Armitage J. High-risk elderly patients PROSPER from cholesterol-lowering therapy. Lancet 2002; 360: 1618-9

Danesh J, Whincup P, Lewington S, Walker M, Lennon L, Thomson A, Wong YK, Zhou X, Ward M. Chlamydia pneumoniae IgA titres and coronary heart disease: prospective study and meta-analysis. Eur Heart J 2002; 23: 371-5

Darby SC. Discussion on 'Residential radon and alpha emitters'. Radiat Res 2002; 158: 783-90

de Jager CA, Budge M, Clarke R. Utility of TICS-M to assess cognitive function in older adults. Int J Geriatr Psychiatr 2002; 8: 318-24.

den Heijer T, Vermeer S, Clarke R, Oudkerk M, Koudstaal PJ, Hofman A, Breteler MMB. Homocysteine, medial temporal lobe and generalised brain atrophy on MRI of non-demented elderly. Brain 2003; 126: 170-5

Doll R. Proof of causality: deduction from epidemiological observation. Perspect Biol Med 2002; 46: 499-515

Doll R. Past, present and future of the smoking epidemic. J R Coll Physicians Edinb, 2002; 32: 24-30

Doll R. The role of data monitoring committees. In: Clinical Trials: into the new millennium. eds. L. Duley, B. Farrell, BMJ Books 2002, pp.97-104. London

Early Breast Cancer Trialists' Collaborative Group (includes Clarke M). Radiotherapy for early breast cancer (Cochrane Review). In: Cochrane Library, Issue 2, 2002. Oxford: Update Software.

Edwards P, Clarke M, DiGuiseppi C, Pratap S, Roberts I, Wentz R. Identification of randomized controlled trials in systematic reviews: accuracy and reliability of screening records. Stat Med 2002; 21: 1635-40

Edwards P, Roberts I, Clarke M, DiGuiseppi C, Pratap S, Wentz R, Kwan I. Increasing response rates to postal questionnaires: systematic review. BMJ 2002; 324: 1183-5

Gray R, Collins R, Peto R, Wheatley K. Large-scale randomized evidence: trials and overviews. Chapter 58 in: P Price, K Sikora (eds). Treatment of Cancer, 4th edition. Arnold, London, 2002

Heart Protection Study Collaborative Group (writing committee: Collins R, Armitage J, Parish S, Sleight P, Peto R). MRC/BHF Heart Protection Study of cholesterol lowering with simvastatin in 20,536 high-risk individuals: a randomised placebo-controlled trial. Lancet 2002; 360: 7-22

Heart Protection Study Collaborative Group (writing committee: Collins R, Armitage J, Parish S, Sleight P, Peto R). MRC/BHF Heart Protection Study of antioxidant vitamin supplementation in 20,536 high-risk individuals: a randomised placebo-controlled trial. Lancet 2002; 360: 23-33

Homocysteine Studies Collaboration (writing committee: R Clarke, S Lewington, A Donald, R Collins). Homocysteine and risk of ischemic heart disease and stroke: a meta-analysis. JAMA 2002; 288: 2015-22

Huxley R, Lewington S, Clarke R. Cholesterol, coronary heart disease and stroke: a review of published evidence from observational studies and randomized controlled trials. Seminars Vascular Medicine 2002; 2: 315-23

Huxley R, Neil A, Collins R. Unravelling the "fetal origins" hypothesis: is there really an inverse association between birth weight and subsequent blood pressure? Lancet 2002; 360: 659-65

International Subarachnoid Aneurysm Trial (ISAT) Collaborative Group (includes Clarke M). International Subarachnoid Aneurysm Trial (ISAT) of neurosurgical clipping versus endovascular coiling in 2143 patients with ruptured intracranial aneurysms. Lancet 2002; 360: 1267-74

Jabber-Al-Obaidi MS,Martineau M, Bennett CF, Franklin IM, Goldstone AH, Harewood L, Jalali GR, Prentice HG, Richards SM, Roberts K, Harrison CJ. ETV6/AML1 fusion by FISH in adult lymphoblastic leukemia. Leukemia 2002; 16: 669-74

Jiang LX, Chen ZM, Xie JX, Collins R, Peto R, Liu LS. Survey of hospital management of myocardial infarction in China. J Clinical Cardiol 2002; 18: 417-20

Klerk M Verhoef P, Clarke R, Blom HJ, Kok FJ, Schouten EG. MTHFR 677C to T polymorphism and risk of coronary heart disease: a meta-analysis. JAMA 2002; 288: 2023-31

Landray MJ, Edmunds E, Li-Saw-Hee FL, Hughes BA, Beevers DG, Kendall MJ, Lip GYH. Abnormal low-density lipoprotein subfraction profile in patients with untreated hypertension. QJM 2002; 95: 165-71

Landray MJ, Toescu V, Kendall MJ. The cardioprotective role of beta-blockers in patients with diabetes mellitus. J Clin Pharm Ther 2002; 27: 233-42

Landray MJ, Whitlock G. Evaluating treatment effects reliably: Although principles are well known, they are ignored too often. BMJ 2002; 325: 1372-73

Lewington S, Clarke R, Quizilbash N, Peto R, Collins R for the Prospective Studies Collaboration. Age-specific relevance of usual blood pressure to vascular mortality: One million adults in 61 prospective studies. Lancet 2002; 360:1903-13.

Lip GY, Edmunds E, Nuttall SL, Landray MJ, Blann AD, Beevers DG. Oxidative stress in malignant and non-malignant phase hypertension. J Hum Hypertens 2002; 16: 333-6

Mallet S, Clarke M. The 'average' Cochrane systematic review: How many trials? How many participants? Int J Tech Assess Health Care 2002; 18: 820-3

McDonald S, Westby M, Clarke M, Lefebvre C, The Cochrane Centres' Working Group On 50 Years Of Randomized Trials. Number and size of randomized trials in general health care journals from 1948 to 1997. Int J Epidemiol 2002; 31: 125-7

Prins ND, Den Heijer T, van Dijk EJ, Jolles J, Koudstaal PJ, Hofman A, Clarke R, Breteler MMB. Homocysteine and cognitive function in the elderly: The Rotterdam study. Neurology 2002; 59: 1375-80

Prospective Studies Collaboration (writing committee: Lewington S, Clarke R, Qizilbash N, Peto R, Collins R). Age-specific relevance of usual blood pressure to vascular mortality: a meta-analysis of one million adults in 61 prospective studies. Lancet 2002; 360: 1903-13

Taylor CW, Gerrard G. Chinese herbal remedies and radiotherapy. Clinical Oncology 2002; 14: 431

Teo KK, Yusuf S, Pfeffer M, Kober L, Hall A, Pogue J, Latini R, Collins R, for the ACE Inhibitors Collaborative Group. Effects of long-term treatment with angiotensin-converting-enzyme inhibitors in the presence or absence of aspirin: a systematic review. Lancet 2002; 360: 1033-43

The Magpie Trial Collaborative Group (includes Clarke M and Collins R). Do women with pre-eclampsia, and their babies, benefit from magnesium sulphate? The Magpie Trial: a randomised placebo-controlled trial. Lancet 2002; 359: 1877-90

The Royal Society Working Group on the Health Hazards of Depleted Uranium Munitions (Members: Bailey MR, Beral V, Clayton B, Darby SC, Goodhead DT, Hendry J, Marsh C, Murray V, Smith B, Spratt B (Chairman), Stoneham M, Al-Bader S, Collins P, Green N, Scott M, Wilkins M) The health effects of depleted uranium munitions: a summary. J Radiol Prot 2002; 22: 131-9

The Royal Society Working Group on the Health Hazards of Depleted Uranium Munitions (Bailey MR, Beral V, Clayton B, Darby SC, Goodhead DT, Hendry JH, Marsh C, Murray V, Smith B, Spratt BG (Chairman), Stoneham M). The Health Hazards of Depleted Uranium Munitions: Part II. London, The Royal Society, 2002

UKCCS Investigators (including R Doll) Exposure to power frequency electric fields and the risk of childhood cancer in the UK. Br J Cancer 2002; 87:1257-61

UKCCS Investigators (including R Doll) The United Kingdom Childhood Cancer Study of exposure to domestic sources of ionizing radiation: I: radon gas. Br J Cancer 2002; 86: 1721-6

UKCCS Investigators (including R Doll) The United Kingdom Childhood Cancer Study of exposure to domestic sources of ionizing radiation: 2: gamma radiation. Br J Cancer 2002; 86: 1727-31

Vermeer SE, van Dijk EJ, Koudstaal PJ, Oudkerk M, Hofman A, Clarke R, Breteler MBE. Homocysteine, silent brain infarcts and white matter lesions: the Rotterdam Scan Study. Ann Neurol 2002; 51: 285-9

Wilde JT, Lee CA, Darby SC, Kan SW, Giangrande P, Phillips AN, Winter M, Spooner R, Ludlam CA on behalf of the UK Haemophilia Centre Doctors' Organisation. The incidence of lymphoma in the UK haemophilia population between 1978 and 1999. AIDS 2002; 16: 1803-07

Youngman LD, Clark S, Manley S, Peto R, Collins R. Reliable measurement of glycated hemoglobin in frozen blood samples: implications for epidemiologic studies. Clin Chem 2002; 48: 1627-9

Publications in 2001

Advisory Group on Non-ionising Radiation (Chairman R. Doll). ELF Electromagnetic Fields and the Risk of Cancer. Documents of the NRPB 2001;12, No.1. National Radiological Protection Board, Didcot

Algra A, Brilstra EH, Clarke M, van Gijn J, Molyneux A, Rinkel GJE, van Rooij WJJ. Endovascular coiling versus neurosurgical clipping for patients with aneurysmal subarachnoid haemorrhage (Protocol for a Cochrane Review). In: Cochrane Library, Issue 2, 2001. Oxford: Update Software

Baigent C, Collins R, Peto R. Benefit of aspirin plus ACE inhibitor. Am J Cardiol 2001; 37: 1474-5

Berrington A, Darby SC, Weiss HA, Doll R. 100 years of observation on British radiologists: mortality from cancer and other causes 1897-1997. Br J Radiol 2001; 74: 507-19

Bonifazi F, deVivo A, Rosti G, Guilhot F, Guilhot J, Trabacchi E, Hehlmann R, Hochhaus A, Shepherd S, Steegman JL, Kluin-Nelemans HC, Thaler J, Simonsson B, Lowagie A, Reiffers J, Mahon FX, Montefusco E, Alimena G, Hasford J, Richards S, Saglio G, Testoni N, Martinelli G, Tura S, Baccarani M. Chronic myeloid leukemia and interferon-alpha: a study of complete cytogenetic responders. Blood 2001; 98: 3074-81

Breeze E, Fletcher AE, Leon DA, Marmot MG, Clarke R, Shipley MJ. Socioeconomic disadvantage persists into old age: self-reported morbidity in a 29 year follow-up of the Whitehall Study. Am J Publ Health 2001; 91: 277-83

Chessells JM, Harrison G, Richards SM, Bailey CC, Hill F, Gibson BE, Hann IM. Down syndrome and acute lymphoblastic leukaemia: clinical features and response to treatment. Arch Dis Child 2001; 85: 321-5

Clarke M, Halsey J. DICE 2: a further investigation of the effects of chance in life, death and subgroup analyses. Int J Clin Pract 2001; 55: 240-2

Clarke M, Horton R. Bringing it all together: Lancet-Cochrane collaborate on systematic reviews. Lancet 2001; 357: 1728

Clarke M, Stewart LA. Obtaining individual patient data from randomised controlled trials. In: Egger M, Davey Smith G, Altman DG (eds). Systematic Reviews in Health Care: Meta-analysis in Context, 2nd ed. BMJ Books 2001; 109-21

Clarke M, Stewart L, Tierney J, Williamson P. Individual patient data meta-analyses compared with meta-analyses based on aggregate data (Protocol for a Cochrane Methodology Review). In: Cochrane Library, Issue 3, 2001. Oxford: Update Software

Clarke R. Design of clinical trials to test the homocysteine hypothesis of vascular disease. In: Carmel R, Jacobsen D (eds). Homocysteine in Health and Disease. Cambridge University Press, New York, 2001, 477-84

Clarke R. Prevention of vitamin B-12 deficiency in old age. Am J Clin Nutr 2001; 73: 151-2

Clarke R, Frost C. Dietary fat, blood lipids and coronary heart disease risk. In: Wilson T, Temple N (eds). Frontiers in Nutrition 2001. Humana Press, New Jersey 2001, 121-34

Clarke R, Frost C. Dietary fat, blood lipids and coronary heart disease risk. In Nutritional Health: Strategies for disease prevention. Wilson T, Temple N, (Eds), Humana Press Inc, Totowa, NJ 200

Clarke R, Lewington S, Youngman L, Sherliker P, Peto R, Collins R. Underestimation of the importance of blood pressure and cholesterol for coronary heart disease mortality in old age. Eur Heart J 2001; 23: 286-93

Clarke R, Lewington S, Donald A, Johnston C, Refsum H, Stratton I, Jacques P, Breteler MMB, Holman R. Underestimation of the importance of homocysteine as a risk factor for cardiovascular disease in epidemiological studies. J Cardiovasc Risk 2001; 8: 363-9.

Clarke R, Stansbie D. Assessment of homocysteine as a cardiovascular risk factor in clinical practice. Ann Clin Biochem 2001; 38: 624-32

Collaborative Group on Hormonal Factors in Breast Cancer (analysis & writing committee: V Beral, D Bull, R Doll, R Peto, G Reeves). Familial breast cancer. Lancet 2001; 358: 1389-99

Collins R, MacMahon S. Reliable assessment of the effects of treatment on mortality and major morbidity, I: clinical trials. Lancet 2001; 357: 373-80

Colorectal Cancer Collaborative Group (writing committee: R Gray, R Hills, R Stowe, M Clarke, R Peto, M Buyse, P Piedbois). Adjuvant radiotherapy for rectal cancer: a systematic overview of 8507 patients from 22 randomised trials. Lancet 2001; 358: 1291-304

Danesh J. Helicobacter pylori. In: Schwab, M. (ed). Encyclopedic Reference of Cancer, Springer, Heidelberg, 2001

Danesh, J. Clinical trials and meta-analyses. In Firth, J. (ed). Masterclass. Blackwell Scientific & Royal College of Physicians, Oxford, 2001, pp. 15-22

Danesh J, Collins R. Antibiotics in the prevention of coronary heart disease: review of the randomised trials. In: Mehta JL (ed). Inflammatory and Infectious Basis of Atherosclerosis. Birkhäuser Verlag, Basel, 2001, pp.237-42

Danesh J, Whincup P, Walker M, Lennon L, Thomson A, Appleby P, Rumley A, Lowe GDO. Prospective study of fibrin D-dimer and coronary heart disease. Circulation 2001; 103: 2323-7

Darby S, Deo H, Doll R. A parallel analysis of individual and ecological data on residential radon and lung cancer in south-west England. J Roy Stat Soc Series A 2001; 164: 193-203

Darby S, Hill D, Doll R. Radon: A likely carcinogen at all exposures. Annals of Oncology 2001;12: 1341-1351. [Reprinted in Natural Ionizing Radiation and Health pp 103-26, edited by B. Bølviken. The Norwegian Academy of Science and Letters, Oslo 2002]

Darby S, Whitley E, Doll R, Silcocks P. Diet, smoking and lung cancer: a case-control study of 1000 cases and 1500 controls in South-West England. Br J Cancer 2001; 84: 728-35

Djulbegovic B, Clarke M. Scientific and ethical issues in equivalence trials. JAMA 2001; 285: 1206-8

Doll R. Cohort studies: history of the method: I. Prospective cohort studies. Sozi Präventivmed 2001; 46: 75-86

Doll R. Defamatory article by Martin Walker. Occup Environ Medicine 2001; 58: 136

Doll R. Foreword: Professor Martin Vessey. Pharmacoepidemiol & Drug Safety 2001; 10: 3

Doll R. The causes of cancer. Rev Epidém et Santé Publ 2001; 49: 193-200

Doll R. Commentary: Lung cancer and tobacco consumption. Int J Epidemiol 2001; 30: 30-1

Doll R. The role of data monitoring committees. In: Duley L, Farrell B (eds). Clinical Trials: Into the New Millennium. BMJ Books, London, 2001, pp.97-104

Doll R, Peto R. Rights involve responsibilities for patients. BMJ 2001; 322: 730

Early Breast Cancer Trialists' Collaborative Group. Tamoxifen for early breast cancer (Cochrane Review). In: Cochrane Library, Issue 1, 2001. Oxford: Update Software

Edwards P, Roberts I, Clarke M, Diguiseppi C, Pratap S, Wentz R, Kwan I. Methods to influence response to postal questionnaires (Cochrane Methodology Review). In: Cochrane Library, Issue 3, 2001. Oxford: Update Software

Grimwade D, Walker H, Harrison G, Oliver F, Chatters S, Harrison CJ, Wheatley K, Burnett AK, Goldstone AH, on behalf of the MRC Adult Leukaemia Working Party. The predictive value of hierarchical cytogenetic classification in older adults with AML: analysis of 1065 patients entered into the MRC AML11 trial. Blood 2001; 98: 1312-20

Hann I, Vora A, Harrison G, Harrison C, Eden O, Hill F, Gibson B, Richards S on behalf of the UK Medical Research Council's Working Party on Childhood Leukaemia. Determinants of outcome after intensified therapy of childhood lymphoblastic leukaemia: results from MRC UKALL XI. Br J Haematol 2001; 113: 103-14

Hargrave DR, Hann IM, Richards SM, Hill FG, Lilleyman JS, Kinsey S, Bailey CC, Chessells JM, Mitchell C, Eden OB. Progressive reduction in treatment-related deaths in Medical Research Council childhood lymphoblastic leukaemia trials from 1980 to 1997 (UKALL VIII, X and XI). Br J Haematol 2001; 112: 293-9

Hopewell S, Clarke M. Methodologists and their methods: do methodologists write up their conference presentations or is it just 15 minutes of fame? Int J Tech Assessment in Health Care 2001; 17: 601-3

Hopewell S, Clarke M, Lefebvre C, Scherer R. Handsearching versus electronic searching to identify reports of randomized trials (Protocol for a Cochrane Methodology Review). In: Cochrane Library, Issue 2, 2001. Oxford: Update Software

Kottaridis PD, Gale RE, Frew ME, Harrison G, Langabeer SE, Belton AA, Walker H, Wheatley K, Bowen DT, Burnett AK, Goldstone AH, Linch DC. The presence of a FLT3 internal tandem duplication in patients with acute myeloid leukaemia adds important prognostic information to cytogenetic risk group and response to the first cycle of chemotherapy: analysis of 854 patients from the UK MRC AML 10 and 12 trials. Blood 2001 ;98: 1752-9

Lam TH, Ho SY, Hedley AJ, Mak KH, Peto R. Mortality and smoking in Hong Kong: case-control study of all adult deaths in 1998. BMJ 2001; 323: 361-2

Landray MJ, Thambyrajah J, McGlynn FJ, Jones HJ, Baigent C, Kendall MJ, Townend JN, Wheeler DC. Prospective evaluation of known and suspected cardiovascular risk factors in a cohort of patients with chronic renal impairment: study design and cross-sectional analysis of baseline demographic and biochemical characteristics. Am J Kidney Dis 2001; 38: 537-46

Langabeer SE, Rogers JR, Harrison G, Wheatley K, Walker H, Bain BJ, Burnett AK, Goldstone AH, Linch DC, Grimwade D, on behalf of the MRC Adult Leukaemia Working Party. EVI1 expression in acute myeloid leukaemia. Br J Haematol 2001; 112: 208-11

Lefebvre C, Clarke MJ. Identifying randomised trials. In: Egger M, Davey Smith G, Altman DG (eds). Systematic Reviews in Health Care: Meta-analysis in Context, 2nd ed. BMJ Books 2001; pp69-86

Lewis S, Clarke M. Forest plots: trying to see the wood and the trees. BMJ 2001; 322: 1479-80

MacMahon S, Collins R. Reliable assessment of the effects of treatment on mortality and major morbidity, II: observational studies. Lancet 2001; 357: 455-62

Malik I, Danesh J, Whincup P, Popacosta O, Walker M, Lennon L, Thomson A, Haskard D. Soluble cell adhesion molecules and coronary heart disease: prospective study and meta-analysis. Lancet 2001; 358: 971-75

Mork J, Lie A-K, Glattre E, Hallmans G, Jellum E, Koskela P, Moller B, Pukkala E, Schiller J-T, Youngman L, Lehtinen M, Dillner J. Human papillomavirus infection as a risk factor for squamous-cell carcinoma of the head and neck.  New Engl J Med 2001; 344: 1125-31

Myeloma Trialists' Collaborative Group (secretariat: Alison R, Clarke M, Elphinstone P, Evans V, Gray R, Hicks C, James S, MacKinnon L, Peto R, Richards S, Wheatley K). Interferon as therapy for multiple myeloma: an individual patient data overview of 24 randomized trials and 4012 patients. Br J Haematol 2001; 113: 1020-34

Olsen KL, Hopewell S, Dickersin K, Clarke M, Osman AD. Publication bias in clinical trials (Protocol for a Cochrane Methodology Review). In: Cochrane Library, Issue 3, 2001. Oxford: Update Software

Paietta E, Neuberg D, Richards S, Bennett JM, Han Lei, Racevskis J, Dewald G, Rowe JM, Wiernik PH for the Eastern Cooperative Oncology Group. Rare adult acute lymphoblastic leukemia with CD56 expression in the ECOG experience shows unexpected phenotypic and genotypic heterogeneity. Am J Haematol 2001; 66: 189-96

Ridker PM, Danesh J, Youngman L, Collins R, Stampfer MJ, Peto R, Hennekens CH. A prospective study of Helicobacter pylori seropositivity and the risk for future myocardial infarction among socioeconomically similar US men. Ann Intern Med 2001; 135: 184-8

The Royal Society Working Group on the Health Hazards of Depleted Uranium Munitions (Members: Bailey MR, Beral V, Clayton B, Darby SC, Goodhead DT, Hendry JH, Marsh C, Murray V, Smith B, Spratt BG (Chairman), Stoneham M). The Health Hazards of Depleted Uranium Munitions: Part I. London, The Royal Society, 2001

Sever PS, Dahlöf B, Poulter NR, Wedel H, Beevers G, Caulfield M, Collins R, Kjeldsen SE, McInnes GT, Mehlsen J, Nieminen M, O'Brien E, Ostergren J. Rationale, design, methods and baseline demography of participants of the Anglo-Scandinavian cardiac outcomes trial. J Hypertens 2001; 19: 1-8

Simonato L, Agudo A, Ahrens W, Benhamou E, Benhamou S, Boffetta P, Brennan P, Darby SC, Forastiere F, Fortes C, Gaborieau V, Gerken M, Gonzalez CA, Jöckel K-H, Kreuzer M, Merletti F, Nyberg F, Pershagen G, Pohlabeln H, Rösch F, Whitley E, Wichmann H-E, Zambon P. Lung cancer and cigarette smoking in Europe: an update of risk estimates and an assessment of heterogeneity. Int J Cancer 2001; 91: 876-87

Taylor CW, Sinha A, Nightingale JMD. Dysphagia and thoracoabdominal aneurysm. Postgrad Med J 2001; 77: 257-8

van Dijk EJ, Vermeer SE, den Heijer T, Oudkerk M, Hofman A, Koudstaal PJ, Clarke R, Breteler MBE. Homocysteine and cerebral white matter lesions: the Rotterdam Scan Study. Stroke 2001; 32: 321

Publications in 2000

Altman DG, Deeks JJ, Clarke M, Cates C. The quality of systematic reviews: high quality reporting of both randomised trials and systematic reviews should be priority (letter). BMJ 2000; 321: 297

Armitage J, Collins R. Need for large scale randomised evidence about lowering LDL cholesterol in people with diabetes mellitus: MRC/BHF heart protection study and other major trials. Heart 2000; 84: 357-60

Baigent C, Burbury K, Wheeler D. Premature cardiovascular disease in chronic renal failure. Lancet 2000 356: 147-53

Baigent C, Wheeler D. Should we reduce blood cholesterol to prevent cardiovascular disease among patients with chronic renal failure? Nephrol Dial Transplant 2000; 15: 1118-19

Baithwood J, Peniket A, Watkins F, Shepherd P, McGale P, Richards S, Fider C, Littlewood TJ, Wainscoat JS. Telomere length shortening in Chronic Myelogenous Leukemia is associated with reduced time to accelerated phase. Blood 2000; 96; 358-61

Betteridge DJ, Colhoun H, Armitage J. Status report of lipid-lowering trials in diabetes. Current Opinion Lipidology 2000; 11: 621-6

Brennan P, Butler J, Agudo A, Benhamou S, Darby S, Fortes C, Jckel K-H, Kreuzer M, Nyberg F, Pohlabeln H, Saracci R, Wichmann H-E, Boffetta P. Joint effect of diet and environmental tobacco smoke on risk of lung cancer among non-smokers. J Natl Cancer Inst 2000; 92, 426-7.

Brennan P, Fortes C, Butler J, Agudo A, Benhamou S, Darby S, Gerken M, Jckel K-H, Kreuzer M, Mallone S, Nyberg F, Pohlabeln H, Ferro G, Boffetta P. A multicenter case-control study of diet and lung cancer among non-smokers. Cancer Causes and Control 2000; 11: 49-58

Chen ZM, Xu Z, Collins R, Li WX, Peto R. Smoking and mortality in China: a prospective study of 9351 middle-aged adults in Shanghai, with 16-year follow-up. In: Lu R, Mackay J, Niu S, Peto R (eds). Tobacco: The Growing Epidemic. Springer Verlag, London, 2000, pp.84-90

Chen ZM, Sandercock P, Pan HC, Counsell C, Collins R, Liu LS, Xie JX, Warlow C, Peto R, on behalf of the CAST and IST collaborative groups. Indications for early aspirin use in acute ischemic stroke: a combined analysis of 40,000 randomized patients from the Chinese Acute Stroke Trial and the International Stroke Trial. Stroke 2000; 31: 1240-9

Chronic Myeloid Leukaemia Trialists' Collaborative Group (secretariat: Alison R, Clarke M, Evans V, Godwin J, MacKinnon E, Richards S). Hydroxyurea versus busulphan for chronic myeloid leukaemia: an individual patient data meta-analysis of three randomised trials. Br J Haematol 2000; 110; 573-6

Clark R, Byatt S-A, Bennett CF, Brama M, Martineau M, Moorman AV, Roberts K, Secker-Walker LM, Richards S, Eden OB, Goldstone AH, Harrison CJ. Monosomy 20 as a pointer to dicentric (9;20) in acute lymphoblasitc leukemia. Leukemia 2000; 14; 241-6

Clarke M, Clarke T. A study of the references used in Cochrane protocols and reviews: three Bibles, three dictionaries, and nearly 25,000 other things. Int J Tech Assess in Health Care 2000; 16: 907-9

Clarke M, Oxman AD (eds). Cochrane Reviewers Handbook 4.1 ([updated June 2000]. In: The Cochrane Library, Issue 4, 2000. Update Software, Oxford

Clarke M. Quality of evidence for treatment of prostate cancer (letter). JAMA 2000; 284: 1785-6

Clarke M. The QUORUM statement (letter). Lancet 2000; 355: 756-7

Clarke M. What is so important about systematic reviews? Acta Psychiat Scand 2000; 102: 239-40

Clarke R, Armitage J. Vitamin supplements and cardiovascular risk: review of the randomized trials of homocysteine-lowering vitamin supplements. Seminars in Thrombosis & Hemostasis 2000; 26: 341-8

Clarke R, Breeze E, Youngman L, Sherliker P, Bell P, Shah S, Shipley M, Collins R, Leon D, Marmot M, Fletcher A. Re-survey of the Whitehall study of London civil servants: changes in risk factors for cardiovascular disease during 29 years of follow-up. J Cardiovasc Risk 2000; 7: 251-7

Clarke R, Joachim C, Esiri M, Morris J, Bungay H, Molyneux A, Budge M, Frost C, King E, Barnetson L, Smith AD. Leukoaraiosis at presentation and disease progression during follow-up in histologically confirmed cases of dementia. Ann NY Acad Sci 2000; 903: 497-500

Clarke R. An overview of homocysteine lowering clinical trials. In: Robinson K (ed). Homocysteine and Vascular Disease. Kluwer Academic Publishers, Dordrecht, 2000; 413-29

Collaborative Group on AIDS Incubation and HIV Survival including the CASCADE EU Concerted Action. (Analysis and writing committee: Babiker A, Darby S, De Angelis D, Ewart D, Porter K.) Time from HIV-1 seroconversion to AIDS and death before widespread use of highly-active antiretroviral therapy: a collaborative re-analysis. Lancet 2000; 355: 1131-7

Collins R, Rodgers A, Prentice C, MacMahon S on behalf of the PEP Trial Collaborative Group. PEP trial (letter). Lancet 2000; 356: 250-1

Dalesio O, van Tinteren H, Peto R, Clarke M, Schroder FH. Androgen blockade in advanced prostate cancer (letter). Lancet 2000; 356: 341-2

Danesh J. Estimating the contribution of Helicobacter pylori to gastric cancer (letter). Br J Cancer 2000; 83: 970

Danesh J, Collins R, Peto R, Lowe GDO. Haematocrit, viscosity, erythrocyte sedimentation rate: meta-analyses of prospective studies of coronary heart disease. Eur Heart J 2000; 21: 515-20

Danesh J, Collins R, Peto R. Lipoprotein(a) and coronary heart disease: meta-analysis of prospective studies. Circulation 2000; 102: 1082-5

Danesh J, Gasbarrini A, Cremoni I, Gasbarrini G. Extra-digestive diseases and Helicobacter pylori. Current Opin Gastroenterol 2000; 16: S52-S55

Danesh J, Lawrence M, Murphy M, Roberts S, Collins R. Systematic review of the epidemiological evidence on Helicobacter pylori infection and nonulcer or uninvestigated dyspepsia. Arch Intern Med 2000; 160: 1192-8

Danesh J, Pepys MB. C-reactive protein in healthy and in sick populations. Eur Heart J 2000; 21: 1564-5

Danesh J, Pounder RE. Eradication of Helicobacter pylori and non-ulcer dyspepsia. Lancet 2000; 355: 766-7

Danesh J, Whincup P, Walker M, Lennon L, Thomson A, Appleby P, Hawkey C, Atherton J. High prevalence of potentially virulent strains of Helicobacter pylori in the general male British population. Gut 2000; 47: 23-5

Danesh J, Whincup P, Walker M, Lennon L, Thomson A, Appleby P, Gallimore JR, Pepys MB. Low grade inflammation and coronary heart disease: prospective study and updated meta-analyses. BMJ 2000; 321: 199-204

Danesh J, Whincup P, Walker M, Lennon L, Thomson A, Appleby P, Wong YK, Thomas M, Ward M. Chlamydia pneumoniae IgG titres and coronary heart disease: prospective study, updated meta-analysis, and implications for trials of antibiotic treatments. BMJ 2000; 321, 208-13.

Darby S, Doll R. Explaining the lung cancer versus radon exposure data for US counties. J Radiol Prot 2000; 20: 221-2

Devlin AM, Ling E-H, Peerson JM, Fernando S, Clarke R et al. Glutamate carboxypeptidase II: a polymorphism associated with lower levels of serum folate and hyperhomocysteinemia. Human Mol Genet 2000; 9: 2837-44

Doll R, Peto R, Boreham J, Sutherland I. Smoking and dementia in male British doctors: prospective study. BMJ 2000; 320: 1097-1102

Doll R, Peto R. Smoking and dementia in male British doctors (letter). BMJ 2000; 321: 379

Doll R. Smoking and lung cancer: how it really happened. Am J Respir Crit Care Med 2000; 162: 4-6

Durrant IJ, Richards SM, Prentice HG, Goldstone AH. The Medical Research Council trials in adult acute lymphocytic leukema. In: Advances in the Treatment of Adult Acute Lymphocytic Leukemia, Part I. Hematology/Oncology Clinics of North America 2000; 14: 1327-52

Early Breast Cancer Trialists' Collaborative Group (writing committee: Clarke M, Collins R, Darby S, Davies C, Godwin J, Gray R, Peto R). Favourable and unfavourable effects on long-term survival of radiotherapy for early breast cancer: an overview of the randomised trials. Lancet 2000; 355: 1757-70

Eden OB, Harrison G, Richards S, Lilleyman JS, Chessells JM, Hann IM, Hill FGH, Gibson BES on behalf of the Medical Research Council Childhood Leukaemia Working Party. Long term follow-up of the United Kingdom Medical Research Council protocols for childhood acute lymphoblastic leukaemia, 1980-97. Leukemia 2000; 14: 2193-94

Edwards P, Clarke M, Diguiseppi C, Roberts I, Pratap S, Wentz R. Methods to influence response to postal questionnaires (protocol for a Cochrane review). In: The Cochrane Library, Issue 4, 2000. Update Software, Oxford

Frassoni F, Richards S. Commentary and response on randomised studies in acute myeloid leukaemia: the double truth. Bone Marrow Transplantation 2000; 25: 471-3

Gajalakshmi CK, Shanta V, Peto R. Pilot studies on tobacco use in Chennai (Madras), India. In: Lu R, Mackay J, Niu S, Peto R (eds). Tobacco: The Growing Epidemic. Springer Verlag, London, 2000, pp.40-1

Gray R, Bentham P, Raftery J. Effectiveness of rivastigmine in Alzheimer's disease. Participation in trials should be based on clinical uncertainty, not enforcement (letter). BMJ 2000; 320: 511-12

Gray R, Davies C, Perry P. Tamoxifen for early breast cancer: better late than never. Ann Oncol 2000; 11: 505-7

Gray R, Kerr D, Barnwell J, McConkey C. Adjuvant chemotherapy (letter). Lancet 2000; 356: 1276

Green J, Banks E, Berrington A, Darby S, Deo H, Newton, R. N-acetyltransferase 2 and bladder cancer: an overview and consideration of the evidence for gene-environment interaction. Br J Cancer 2000; 83: 412-17

Hancock BW, Harris S, Wheatley K, Gore M. Adjuvant interferon-alpha in malignant melanoma current status. Cancer Treatment Reviews 2000; 26: 81-9

Hann J, Vora A, Richards S, Hill F, Gibson B, Lilleyman JS, Mitchell C, Eden DB. Benefit of intensified treatment for all children with acute lymphoblastic leukaemia: results from MRC UKALLXI and MRC ALL97 randomised trials. Leukemia 2000; 14; 356-63

Hargrave DR, Hann IM, Richards SM, Hill FG, Lilleyman JS, Kinsey S, Bailey CC, Chessells JM, Mitchell C, Eden OB on behalf of the Medical Research Council Working Party for Childhood Leukaemia. Progressive reduction in treatment-related deaths in Medical Research Council childhood lymphoblastic leukaemia trials from 1980 to 1997 (UKALL VIII, X and XI). Br J Haematol 2000; 112: 1-8

Harrison G, Richards S, Lawson S, Darbyshire P, Pinkerton R, Stevens R, Oakhill A, Eden OB, on behalf of the MRC Childhood Leukaemia Working Party. Comparison of allogeneic transplant versus chemotherapy for relapsed childhood acute lymphoblastic leukaemia in the MRC UKALLRI trial. Annals of Oncology 2000; 11: 999-1006

Hassan F, Gelband H, Peto R. High prevalences of obesity, hypertension and smoking in an Egyptian population. In: Lu R, Mackay J, Niu S, Peto R (eds). Tobacco: The Growing Epidemic. Springer Verlag, London, 2000

Keavney B, McKenzie C, Parish S, Palmer A, Clark S, Youngman L, Delpine M, Lathrop M, Peto R, Collins R for the International Studies of Infarct Survival (ISIS) Collaborators. Large-scale test of hypothesised associations between the angiotensin converting enzyme insertion/deletion polymorphism and myocardial infarction in about 5000 cases and 6000 controls. Lancet 2000; 355: 434-42

Kerr DJ, Gray R, McConkey C and Barnwell J, for the QUASAR Colorectal Cancer Study Group. Adjuvant chemotherapy with 5-fluorouracil, L-folinic acid and levamisole for patients with colorectal cancer: Non-randomised comparison of weekly versus four-weekly schedules -- less pain, same gain. Ann Oncol 2000; 11: 947-55

Latini R, Tognoni G, Maggioni AP, Baigent C, Braunwald E, Chen Z-M, Collins R, Flather M, Franzosi MG, Kjekshus J, Kber L, Liu L-S, Peto R, Pfeffer M, Pizzetti F, Santoro E, Sleight P, Swedberg K, Tavazzi L, Wang W, Yusuf S, on behalf of the Angiotensin-converting Enzyme inhibitor Myocardial Infarction Collaborative Group. Clinical effects of early angiotensin-converting enzyme inhibitor treatment for acute myocardial infarction are similar in the presence and absence of aspirin: systematic overview of individual data from 96,712 randomized patients. J Am Coll Cardiol 2000; 35: 1801-7

Lawson SE, Harrison G, Richards S, Oakhill A, Stevens R, Eden OB, Darbyshire PJ on behalf of the MRC Childhood Leukaemia Working Party. The UK experience in treating relapsed childhood acute lymphoblastic leukaemia: a report on the Medical Research Council UKALLRI study. Br J Haematol 2000; 108; 531-43

Lu R, Mackay J, Niu S, Peto R (eds). Tobacco: The Growing Epidemic. Proceedings of the Tenth World Conference on Tobacco or Health, 24-28 August 1997, Beijing, China. Springer Verlag, London, 2000

Nexo E, Engbaek F, Ueland PM, Westby C, O'Gorman P, Johnston C, Kase BF, Guttormsen AB, Alfheim I, McPartlin J, Smith D, Mller J, Rasmussen K, Clarke R, Scott JM, Refsum H. Evaluation of novel assays in clinical chemistry: quantification of plasma total homocysteine. Clin Chem 2000; 46: 1150-6

Niu S, Yang GH, Chen ZM, Chen JL, Wang GH, He XZ, Schoepff H, Boreham J, Peto R. Emerging tobacco hazards in China: results on early mortality from a prospective study of 224,500 men. In: Mackay J, Niu S, Peto R (eds). Tobacco: The Growing Epidemic. Springer-Verlag, London, 2000, p

Peto R. Misconduct in clinical trials: are we over-reacting? Proc Roy Coll Phys Edinburgh 2000; Supplement 7: 25

Peto R, Baigent C. The need for large-scale randomized evidence for reliable assessment of moderate benefits. In: Nabholtz J-M, Tonkin K, Aapro MS, Buzdar AU (eds). Breast Cancer Management. Application of Evidence to Patient Care. Martin Dunitz, London, 2000, pp.51-6

Peto R, Boreham J, Clarke M, Davies C, Beral V. UK and USA breast cancer deaths down 25% in year 2000 at ages 20-69 (letter). Lancet 2000; 355: 1822

Peto R, Darby S, Deo H, Silcocks P, Whitley E, Doll R. Smoking, smoking cessation, and lung cancer in the UK since 1950: combination of national statistics with two case-control studies. BMJ 2000; 321: 323-9

Peto R, Lopez AD. The future worldwide health effects of current smoking patterns. In: Koop CE, Pearson C, Schwarz MR (eds). Global Health in the 21st Century. Jossey-Bass, New York, 2000

Prostate Cancer Trialists' Collaborative Group (writing committeee: Daleso O, van Tinteren H, Clarke M, Peto R, Schrder FH). Maximum androgen blockade in advanced prostate cancer: an overview of the randomised trials. Lancet 2000; 355: 1491-8

Pulmonary Embolism Prevention (PEP) Trial Collaborative Group (writing committee: Rodgers A, MacMahon S, Collins R, Prentice C). Prevention of pulmonary embolism and deep vein thrombosis with low dose aspirin: Pulmonary Embolism Prevention (PEP) trial. Lancet 2000; 355: 1295-1302

Qizilbash N, Birks J, Lopez-Arrieta J, Lewington S, Szeto S. Tacrine for Alzheimer's disease (Cochrane Review). In: The Cochrane Library, Issue 3, 2000. Update Software: Oxford

Qizilbash N, Lewington S, Lopez-Arrieta JM. Corticosteroids for acute ischaemic stroke (Cochrane Review). In: The Cochrane Library, Issue 3, 2000. Update Software: Oxford

QUASAR Collaborative Group (writing committee: Gray RG, Kerr DJ, McConkey CC, Williams NS, Hills RK). Comparison of fluorouracil with additional levamisole, higher-dose folinic acid, or both, as adjuvant chemotherapy for colorectal cancer: a randomised trial. Lancet 2000; 355: 1588-96

Richard SM. Treatment of head lice (letter). Lancet 2000; 356: 2007

Richards SM. Survival analysis in bone marrow transplantation. In: Bidwell J, Navarette C (eds). Histocompatibility Testing. Imperial College Press, 2000, pp.427-38

Second Chinese Cardiac Study (CCS-2) Collaborative Group (steering committee: Liu LS, Collins R, Chen ZM, Xie JX, Jiang LX, Wang W, Pan HC, Peto R et al). Rationale, design and organization of the Second Chinese Cardiac Study (CCS-2): a randomized trial of clopidogrel plus aspirin, and of metoprolol, among patients with suspected acute myocardial infarction. J Cardiovasc Risk 2000; 7: 435-41

Tierney JF, Clarke M, Stewart LA. Is there bias in the publication of individual patient data meta-analyses? Int J Technol Assess Health Care 2000; 16: 657-67

UKCCS Investigators (including R. Doll). The United Kingdom Childhood Cancer Study: objectives, materials and methods. Br J Cancer 2000; 82: 1073-1102

Wheeler D, Baigent C. Cardiovascular risk factors in chronic renal failure. In: Loscalzo J, London G (eds). Cardiovascular Disease in End-stage Renal Failure. Oxford University Press, Oxford, 2000, pp.3-23

Wheeler KA, Richards SM, Bailey CC, Gibson B, Hill FGH, Chessells JM on behalf of the Medical Research Council Working Party on Childhood Leukaemia. Bone marrow transplantation versus chemotherapy in the treatment of very high risk childhood acute lymphoblastic leukemia in first remission: results from MRC UKALLX and XI. Blood 2000; 96: 2412-18

Whincup P, Danesh J, Walker M, Lennon L, Thomson A, Appleby P, Hawkey C, Atherton J. Prospective study of potentially virulent strains of Helicobacter pylori and coronary heart disease in middle-aged men. Circulation 2000; 101: 1647-52

Publications in 1999

Armitage J. Lipid-lowering trials in diabetes. Eur Heart J 1999; M13-M17

Baigent C, Armitage J. Cholesterol reduction among patients at increased risk of coronary heart disease. Proc R Coll Physicians Edinb 1999; 29(Suppl 5): 10-15

Baigent C, Chen Z, Collins R, Peto R, Sudlow. Immediate aspirin for suspected ischaemic stroke (letter). Lancet 1999; 353: 151-2

Baigent C, Collins R, Peto R. Large-scale randomized trials. In: Hennekens CH (ed). Clinical Trials in Cardiovascular Disease. W B Saunders, 1999, pp.24-30

Baigent C, Collins R. Aspirin and heparin. In: Hennekens CH (ed). Clinical Trials in Cardiovascular Disease. W B Saunders, 1999, pp.55-64

Baigent C, Collins R. Thrombolytic therapy. In: Hennekens CH (ed). Clinical Trials in Cardiovascular Disease. W B Saunders, 1999, pp.65-75

Baigent C, Peto R. Safety of metformin in Type 2 diabetes mellitus. Diabetic Medicine 1999; 16: 89-90

Bentham P, Gray R, Sellwood E, Raftery J. Effectiveness of rivastigmine in Alzheimer's disease. Improvements in functional ability remain unestablished (letter). BMJ 1999; 319: 640-1

Bosanquet AG, Johnson SA, Richards SM. Prognosis for fludarabine therapy of chronic lymphocytic leukaemia based on ex vivo drug response by DiSC assay. Br J Haematol 1999; 106: 71-7

Burnett AK, Grimwade D, Solomon E, Wheatley K, Goldstone AH. Presenting white cell count and kinetics of molecular remission predict prognosis in acute promyelocytic leukaemia treated with all-trans retinoic acid: result of the randomised MRC trial. Blood 1999; 93: 4131-43

Clarke M, Oxman A. Cochrane reviews will be in Medline (letter). BMJ 1999; 319: 1435

Clarke M. 50 years of clinical trials: past, present and future. Nordic Newsletter on Evidence-Based Health Care 1999; 3: 6-7

Clarke R, Shipley M, Lewington S, Youngman L, Collins R, Marmot M, Peto R. Underestimation of risk associations due to regression dilution in long-term follow-up of prospective studies. Am J Epidemiol 1999; 150: 341-53

CLL Trialists' Collaborative Group (writing committee: Richards S, Clarke M, Wheatley K, Peto R). Chemotherapeutic options in chronic lymphocytic leukemia: a meta-analysis of the randomized trials. J Natl Cancer Inst 1999; 91: 861-8

Cox DR, Darby SC, Reeves GK, Whitley E. The effects of measurement errors with particular reference to a study of exposure to residential radon. In: Hoffman RE (ed). Uncertainties in Radiation Dosimetry and Their Impact on Dose-Response Analyses. National Cancer Institute, National Institutes of Health Publication No. 99-4541. USA, National Institute of Health, 1999, pp. 139-51

Craze JL, Harrison G, Wheatley K, Hann IM, Chessells JM. Improved outcome of acute myeloid leukaemia in Down syndrome. Archives of Disease in Childhood, 1999; 81: 32-7

Danesh J. Macrolides in the secondary prevention of coronary heart disease. Evidence-based Cardiovascular Medicine 1999; 3: 110-11

Danesh J. Coronary heart disease, Helicobacter pylori, dental disease, Chlamydia pneumoniae, and cytomegalovirus: meta-analyses of prospective studies. Am Heart J 1999; 138: 434-7

Danesh J. Helicobacter pylori and gastric cancer: systematic review of the epidemiological studies. Aliment Pharmacol Ther 1999; 13: 851-6

Danesh J. Helicobacter pylori and gastric cancer: time for mega-trials? Br J Cancer 1999; 80: 927-9

Danesh J. Is Helicobacter pylori a cause of gastric neoplasia? In: Beral V, Newton R, Weiss R (eds). Infections and Cancer. Cold Spring Harbor Press, New York, 1999, 263-89

Danesh J. Smoldering arteries? Low-grade inflammation and coronary heart disease. JAMA 1999; 282; 2169-71

Danesh J, Appleby P. Iron status and coronary heart disease: meta-analyses of prospective studies. Circulation 1999; 99: 852-4

Danesh J, Gault S, Semmence J, Appleby P, Peto R. Postcodes as useful markers of income in 26,000 British households. J Epidemiol Community Health 1999; 53: 582

Danesh J, Gault S, Semmence J, Appleby P, Peto R. Postcodes as useful markers of social class: population-based study in 26,000 British households. BMJ 1999: 318: 843-4

Danesh J, Koreth J, Youngman L, Collins R, Arnold JR, Balarajan Y, McGee J, Roskell D. Is Helicobacter pylori a factor in coronary atherosclerosis? J Clin Microbiol 1999; 37: 1651

Danesh J, Muir J, Wong YK, Ward M, Gallimore R, Pepys MB. Risk factors for coronary heart disease and acute-phase proteins: a population-based study. Eur Heart J 1999; 20: 954-59

Danesh J, Newton R, Beral V. The bacteria craze (letter). Lancet 1999; 353: 1447

Danesh J, Wong Y, Ward M, Muir J. Chronic infection with Helicobacter pylori, Chlamydia pneumoniae, or cytomegalovirus: population based study of coronary heart disease. Heart 1999; 81: 245-7

Danesh J, Wong Y, Ward M, Muir J. Risk factors for coronary heart disease and persistent infection with Chlamydia pneumoniae or cytomegalovirus: a population based study. J Cardiovasc Risk 1999; 6: 387-90

Danesh J, Youngman L, Clark S, Parish S, Peto R, Collins R for the International Studies of Infarct Survival (ISIS) Collaborative Group. Helicobacter pylori infection and early onset myocardial infarction: case-control and sibling pairs study. BMJ 1999; 319: 1157-62

Darby S. Radiation risks. Appropriate decisions come from valid data, not inaccurate perceptions of risk. BMJ 1999; 319: 1019-20

Darby SC, Fearn T (1999). Berkson Error Model. In: Encyclopedia of Statistical Sciences, Update Vol 3. Chichester, John Wiley & Sons, 1999, pp.53-4

Doll R. Epidemiologia de doenes crnicas no infecciosos: situaao atuel e perspectives futures. (in English). Revista Brasileira de Epidemiologia 1999; 1: 94-103

Doll R. Risk from tobacco and potentials for health gain. Int J Tuberc Lung Dis 1999; 3: 90-9

Doll R. The Pierre Denoix Memorial Lecture. Nature and nurture in the control of cancer. Eur J Cancer 1999; 15: 16-23

Doll R. The Seascale cluster: a probable explanation. Br J Cancer 1999; 81: 3-6

Doll R. The limits of epidemiology. J Radiol Prot 1999; 19: 1-2

Doll R. Tobacco: a medical history. J Urban Health: Bulletin of the New York Academy of Medicine 1999; 76, 289-313

Doll R, Darby S, Whitley E, Silcocks P, Thakrar B, Green M, Lomas P, Miles J, Reeves G, Fearn T. Involvement of radon levels in lung cancer (letter). Br J Cancer 1999; 79: 1622-3

Doll R, Peto R, Clarke M. First publication of an individually randomized trial (letter). Controlled Clinical Trials 1999; 20: 367-8

Frost C, Clarke R, Beacon H. Use of hierarchical models for meta-analysis: experience in the metabolic ward studies of diet and blood cholesterol. Stat Med 1999; 18: 1657-76

Groves DJ, Smye SW, Kinsey SE, Richards SM, Chessells JM, Eden OB, Bailey CC. A comparison of Cox regression and neural networks for risk stratification in cases of acute lymphoblastic leukaemia in children. Neural Computing & Applications 1999; 8: 257-64

Groves DJ, Smye SW, Kinsey SE, Richards SM, Chessells JM, Eden OB, Bailey CC. Comparison of Cox regression and neural networks for risk stratification in cases of acute lymphoblastic leukaemia in children (letter). Br J Haematol 1999; 104: 198-200

HIV Trialists' Collaborative Group (writing committee: Darbyshire J, Babiker A, Walker S, Collins R, Peto R). Zidovudine, didanosine, and zalcitabine in the treatment of HIV infection: meta-analyses of the randomised evidence. Lancet 1999; 353: 2014-25

Kinjo Y, Beral V, Akiba S, Key T, Mizuno S, Appleby P, YamaguchiI N, Watanabe S, Doll R. Possible protective effect of milk, meat and fish for cerebrovascular disease mortality in Japan. J Epidemiology 1999; 9: 268-73

Kreienbrock L, Poffijn A, Tirmarche M, Feider M, Kies A, Darby SC. Intercomparison of passive radon-detectors under field conditions in epidemiological studies. Health Physics 1999; 76: 558-63

Lewington S, MacMahon S on behalf of the Prospective Studies Collaboration. Blood pressure, cholesterol and common causes of death: a review. Am J Hypertens 1999; 12: 96S-98S

Little MP, Weiss HA, Boice Jr JD, Darby SC, Day NE, Muirhead CR. Risks of leukaemia in Japanese atomic bomb surv vors, in women treated for cervical cancer and in patients treated for ankylosing spondyitis. Radiation Research 1999; 152: 280-92

McLeod HL, Coulthard S, Thomas AE, Pritchard SC, King DJ, Richards SM, Eden OB, Hall AG, Gibson BES. Analysis of thiopurine methyltransferase variant alleles in childhood acute lymphoblastic leukaemia. Br J Haematol 1999; 105: 696-700

MRC/BHF Heart Protection Study Collaborative Group (writing committee: Collins R, Armitage J). MRC/BHF Heart Protection Study of cholesterol-lowering therapy and of antioxidant vitamin supplementation in a wide range of patients at increased risk of coronary heart disease death: early safety and efficacy experience. Eur Heart J 1999; 20: 725-41

Pallis M, Turzanski J, Harrison G, Wheatley K, Langabeer S, Burnett AK, Russell NH. Use of standardised flow cytometric determinants of multidrug resistance to analyse response to remission induction chemotherapy in patients with acute myeloblastic leukaemia. Br J Haematol 1999; 104: 307-12

Peto R, Chen ZM, Boreham J. Emerging tobacco hazards in China (letter). BMJ 1999; 318: 1555

Peto R, Chen ZM, Boreham J. Tobacco -- the growing epidemic (letter). Nature Medicine 1999; 5: 15-17

Peto R, Collins R. Better patency with SK than with tPA? (letter). J Am Coll Cardiol 1999; 33: 287-8

Peto R. Cause for alarm (letter). New Scientist 1999; 161: 49

Peto R. Failure of randomisation by "sealed" envelope (letter). Lancet 1999; 354: 73

Peto R. Richard Doll's contribution to epidemiology. Eur J Cancer 1999; 35: 11

Prospective Studies Collaboration (writing committee: Lewington S, MacMahon S, Clarke R, Collins R, Duffy S, Qizilbash N, Rodgers A, Peto R). Collaborative overview ("meta-analysis") of prospective observational studies of the associations of usual blood pressure and usual cholesterol levels with common causes of death: protocol for the second cycle of the Prospective Studies Collaboration. J Cardiovasc Risk 1999; 6: 315-20

Riley LC, Hann IM, Wheatley K, Stevens RF for the MRC Childhood Leukaemia Working Party. Treatment related deaths during induction and first remission of acute myeloid leukaemia in children treated on the Tenth Medical Research Council acute myeloid leukaemia trial (MRC AML10). Br J Haematol 1999; 106; 436-44

Sonksen J, Gray R, Hutton P. Safer non-cardiac surgery for patients with coronary artery disease (letter). BMJ 1999; 319: 320-1

Stiller CA, Benjamin S, Cartwright RA, Clough JV, Gorst DW, Kroll ME, Ross JRY, Wheatley K, Whittaker JA, Taylor PRA, Proctor SJ. Patterns of care and survival for adolescents and young adults with acute leukaemia -- a population based study. Br J Cancer 1999; 79: 658-65

Sudlow CLM, Baigent CN. Randomized trials of antiplatelet therapy. In: Platelet Physiology and Pharmacology. Kluwer Academic Publishers, Dordrecht, The Netherlands, 1999, pp.527-48

Sudlow C, Baigent C. Long term management of cardiovascular risk in asymptomatic people: antithrombotic therapy. In: Godlee F (ed). British Medical Journal / American College of Physicians Clinical Effectiveness Directory: Evidence '99. BMJ Publishing Group, London, 1999, pp.477-8

Sudlow C, Baigent C. Long term management of patients at high risk of ischaemic cardiac events: antiplatelet and anticoagulant therapy. In: Godlee F (ed). British Medical Journal / American College of Physicians Clinical Effectiveness Directory: Evidence '99. BMJ Publishing Group, London, 1999, pp.478-80

Sudlow C, Baigent C. Long term management of patients at high risk of stroke: blood pressure reduction, cholesterol reduction, and antiplatelet therapy. In: Godlee F (ed). British Medical Journal / American College of Physicians Clinical Effectiveness Directory: Evidence '99. BMJ Publishing Group, London, 1999, pp.504-07

UKCCS Investigators (including R. Doll). Exposure to power-frequency magnetic fields and the risk of childhood cancers. Lancet 1999; 354: 1925-31

Walton J, Doll R, Asscher W, Hurley R, Langman M, Gillon R, Strachan D, Wald N, Fletcher P. Consequences for research if use of anonymised patient data breaches confidentiality (letter). BMJ 1999; 319: 1366

Watson M, Wheatley K, Harrison GA, Zittoun R, Gray RG, Goldstone AH. Burnett AK. Severe adverse impact on sexual functioning and fertility of bone marrow transplantation, either allogeneic or autologous, compared with consolidation chemotherapy alone: analysis of the MRC AML 10 trial. Cancer 1999; 86:1231-9

Webb DKH, Wheatley K, Harrison G, Stevens RF, Hann IM. Outcome for children with relapsed acute myeloid leukaemia following initial therapy in the Medical Research Council (MRC) AML10 trial. Leukemia 1999; 13: 25-31

Wheatley K, Burnett AK, Goldstone AH, Gray RG, Hann IM, Harrison CJ, Rees JKH, Stevens RF, Walker H for the United Kingdom Medical Research Council's Adult and Childhood Leukaemia Working Partyies. A simple, robust, validated and highly predictive index for the determination of risk-directed therapy in acute myeloid leukaemia derived from the MRC AML10 trial. Br J Haematol 1999; 107: 69-79

Wheatley K, Richards S. Meta-analysis -- where are we now? Cancer Topics 1999; 10,12: 10-13

Whitley E, Darby SC. Quantifying the risks from residential radon. In: Barnett V, A Stein A, Turkman KF (eds). Statistics for the Environment (4): Statistical Aspects of Health and the Environment. Chichester, John Wiley & Sons, 1999, pp.73-89

Publications in 1998

ACE-inhibitor Myocardial Infarction Collaborative Group (writing committee: Franzosi MG, Santoro E, Zuanetti G, Baigent C, Collins R et al). Indications for ACE-inhibitors in the early treatment of acute myocardial infarction: systematic overview of individual data from 100,000 patients in randomized trials. Circulation 1998; 97: 2202-12

AML Collaborative Group (secretariat: Alison R, Clarke M, Evans V, Gray R, Greaves E, Hall E, Hicks C, James S, Peto R, Richards S, Sinclair D, Tooth A, Wheatley K). A systematic collaborative overview of randomized trials comparing idarubicin with daunorubicin (or other anthracyclines) as induction therapy for acute myeloid leukaemia. Br J Haematol 1998; 103: 100-9

Anderson RM, Darby SC. The role of statistics in human immunodeficiency virus research. J Roy Stat Soc Series A 1998: 161: 161-6

Baigent C, Collins R, Appleby P, Parish S, Sleight P, Peto R on behalf of the ISIS-2 (Second International Study of Infarct Survival) Collaborative Group. ISIS-2: 10 year survival among patients with suspected acute myocardial infarction in randomised comparison of intravenous streptokinase, oral aspirin, both, or neither. BMJ 1998; 316: 1337-43

Beral V, Reeves G, Bull D, Key T, Peto R. Breast cancer and hormone replacement therapy: putting the risk into context. In: Birkhuser MH, Rozenbaum H (eds). Proc IV European Congress on Menopause (Vienna, 8-12 October 1998). Editions Eska, Paris, 1998, pp.267-77

Boffetta P, Agudo A, Ahrens W, Benhamou E, Benhamou S, Darby S, Ferro G, Fortes C, Gonzalez CA, Jckel K-H, Krauss M, Kreienbrock L, Kreuzer M, Mendes A, Merletti F, Nyberg F, Pershagen G, Pohlabeln H, Riboli E, Schmid G, Simonato L, Trdaniel J, Whitley E, Wichmann H-E, Winck C, Zambon P, Saracci R. European multicentre case-control study of lung cancer in non-smokers. IARC Technical Report 33. Lyon, International Agency for Research on Cancer, 1998

Boffetta P, Agudo A, Ahrens W, Benhamou E, Benhamou S, Darby S, Ferro G, Fortes C, Gonzalez CA, Jckel K-H, Krauss M, Kreienbrock L, Kreuzer M, Mendes A, Merletti F, Nyberg F, Pershagen G, Pohlabeln H, Riboli E, Schmid G, Simonato L, Trdaniel J, Whitley E, Wichmann H-E, Winck C, Zambon P, Saracci R. Multicentre case-control study of exposure to environmental tobacco smoke and lung cancer in Europe. J Natl Cancer Inst 1998; 90: 1444-50

Bundy D, Peto R. Anthelminthic treatment for infestation with Trichuris trichiura (letter). Lancet 1998; 352: 1935

Burnett AK, Goldstone AH, Stevens RMF, Hann IM, Rees JKH, Gray RG, Wheatley K, et al for the UK Medical Research Council Adult and Children's Leukaemia Working Parties. Randomised comparison of addition of autologous bone-marrow transplantation to intensive chemotherapy for acute myeloid leukaemia in first remission: results of the AML10 trial. Lancet 1998; 315: 700-8

Chen ZM. Ongoing large randomised trials in China: opportunities and challenges. Drug Infor J 1998; 32: 1193S-1200S

Chessells JM, Hall E, Prentice HG, Durrant J, Bailey CC, Richards SM. The impact of age on outcome in lymphoblastic leukemia: MRC UKALL X and XA compared. Leukemia 1998; 12: 463-73

Clarke M, Chalmers I. Discussion sections in reports of controlled trials published in five general medical journals: islands in search of continents? JAMA 1998; 280: 280-2

Clarke M, Chalmers I. Meta-analyses, multivariate analyses, and coping with the play of chance (letter). Lancet 1998; 351: 1062

Clarke M, Godwin J. Systematic reviews using individual patient data: a map for the minefields? Ann Oncol 1998; 9: 827-33

Clarke M, Stewart L, Pignon J-P, Bijnens L. Individual patient data meta-analyses in cancer. Br J Cancer 1998; 77: 2036-44

Clarke M, Stewart L. Comparison of effect estimates from a meta-analysis of summary data from published studies and from a meta-analysis using individual patient data for ovarian cancer studies (letter). Am J Epidem 1998; 148: 102-3

Clarke M, Stewart L. Time lag bias in publishing clinical trials (letter). JAMA 1998; 279: 1952

Clarke M. Ovarian ablation in breast cancer, 1896 to 1998: milestones along hierarchy of evidence from case report to Cochrane review. BMJ 1998; 317: 1246-8

Clarke R, Breeze E, Sherliker P, Shipley M, Youngman L, Fletcher A, Fuhrer R, Leon D, Parish S, Collins R, Marmot M. Design, objectives, and lessons from a pilot 25 year follow up re-survey of survivors in the Whitehall study of London Civil Servants. J Epidemiol & Com Health 1998; 52: 364-9

Clarke R, Collins R. Can dietary supplements with folic acid or vitamin B₆ reduce cardiovascular risk? Design of clinical trials to test the homocysteine hypothesis of vascular disease. J Cardiovasc Risk 1998; 5: 249-55

Clarke R, Smith AD, Jobst K, Sutton L, Refsum H, Ueland PM. Plasma homocysteine, folate and vitamin B-12 as risk factors for confirmed Alzheimer's disease. Arch Neurol 1998; 55: 1449-55

Clarke R, Woodhouse P, Ulvik A, Frost C, Sherliker P, Refsum H, Ueland PM, Khaw K-T. Variability and determinants of plasma total homocysteine levels in an elderly population. Clin Chem 1998; 44: 102-7

Clarke R. Homocysteine and cardiovascular disease: an in-depth review. J Cardiovasc Risk 1998; 5: 213-15

Collins R, Malacrida R, Moccetti T. Comparison of the early outcome of acute myocardial infarction in women and men (letter). N Engl J Med 1998; 338: 1544

Danesh J. Helicobacter pylori infection and coronary heart disease: a critical look. In: Hunt RH, Tytgat GNJ (eds). Helicobacter pylori: Basic Mechanisms to Clinical Cure. Kluwer Academic, Amsterdam, 1998, 267-73

Danesh J. Is there a link between chronic Helicobacter pylori infection and coronary heart disease? Eur J Surg Suppl 1998; 582: 27-31

Danesh J, Appleby P, Peto R. How often does surgery for peptic ulceration eradicate Helicobacter pylori? Systematic review of 36 studies. BMJ 1998; 316: 746-7

Danesh J, Appleby P. Persistent infection and vascular disease: a systematic review. Expert Opin Invest Drugs 1998; 7: 691-713

Danesh J, Collins R, Appleby P, Peto R. Association of fibrinogen, C-reactive protein, albumin, or leukocyte count with coronary heart disease. JAMA 1998; 279: 1477-82

Danesh J, Lewington S. Plasma homocysteine and coronary heart disease: a systematic review of the published epidemiological evidence. J Cardiovasc Risk 1998; 5: 229-32

Danesh J, Peto R. Helicobacter pylori and surgery (letter). BMJ 1998; 317: 679-80

Danesh J, Peto R. Risk factors for coronary heart disease and infection with Helicobacter pylori: meta-analysis of 18 studies. BMJ 1998; 316: 1130-2

Danesh J, Wong YK, Ward M, Hawtin P, Murphy M, Muir J. Strong correlation between Helicobacter pylori seropositivity and Chlamydia pneumoniae IgG titres. J Epidemiol Comm Health 1998; 52: 821-2

Darby S, Whitley E, Silcocks P, Thakrar B, Green M, Lomas P, Miles J, Reeves G, Fearn T, Doll R. Risk of lung cancer associated with residential radon exposure in south-west England: a case-control study. Br J Cancer 1998; 78: 394-408

Darby S, Whitley E, Silcocks P, Thakrar B, Green M, Lomas P, Miles J, Reeves G, Fearn T, Doll R. Risk of lung cancer associated with residential radon exposure in south-west England: a case-control study. Radiol Prot Bull 1998; 204: 10-13

Darby SC, Ewart DW. Measures of mortality in the study of individuals infected with the human immunodeficiency virus in the UK haemophilia population. J Roy Stat Soc Series A 1998; 161: 191-8

Darby SC, Gilbert ES. Radiation. In: Armitage P, Colton T (eds). Encyclopedia of Biostatistics Vol 5. Chichester, John Wiley & Sons, 1998, pp.3662-8

Davies C, Arriagada R, Ziegler Z, Peralta O. Duration of adjuvant treatment with tamoxifen in patients with resectable breast cancer. Revista Medica de Chile 1998; 126: 210-17

Davies C, McGale P, Peto R. Variation in use of adjuvant tamoxifen (letter). Lancet 1998; 351: 1487-8

Doll R. Epidemiological evidence of the effets of behaviour and the environment on the risk of human cancer. Recent Results Cancer Res 1998; 154: 3-21

Doll R. Concluding remarks. In: Hoffmeister H, Szklo M, Thamm M (eds). Epidemiological practices in research on small effects. Springer, Berlin, 1998, pp.127-32

Doll R. Controlled trials: the 1948 watershed. BMJ 1998; 517: 1217-20

Doll R. Effect of environmental smoke on adults. In: Stockwell T (ed). Drug Trials and Tribulations: Lessons for Australian Drug Policy. National Centre for Research into the Prevention of Drug Abuse, Perth, 1998, pp.1-14

Doll R. Effects of small doses of ionizing radiation. J Radiol Prot, 1998; 18: 163-74

Doll R. The benefit of alcohol in moderation. Drug and Alcohol Review 1998; 17: 353-63

Doll R. The first reports on smoking and lung cancer. In: Lock S, Reynolds L, Tansey EM (eds). Ashes to Ashes: The History of Smoking and Health. Clio Medica, 1998, pp.130-42

Doll R. Uncovering the effects of smoking: historical perspective. Stat Methods Med Res 1998; 7: 87-117

Doll R, Sharp C, Muirhead C, Darby S. Study of UK men who had participated in the UK nuclear weapons test programme (letter). J Radiol Prot 1998; 18: 209

Early Breast Cancer Trialists' Collaborative Group (writing committee: Clarke M, Collins R, Davies C, Godwin J, Gray R, Peto R). Polychemotherapy for early breast cancer: an overview of the randomised trials. Lancet 1998; 352: 930-42

Early Breast Cancer Trialists' Collaborative Group (writing committee: Clarke M, Collins R, Davies C, Godwin J, Gray R, Peto R). Tamoxifen for early breast cancer: an overview of the randomised trials. Lancet 1998; 351: 1451-67

Ewart DW, Darby SC, Lee CA, Giangrande PLF, Spooner RJD, Phillips AN, Ludlam CA on behalf of the UK Haemohilia Centre Directors' Organisation. Immune status in HIV-1 infected men and boys with haemophilia in the United Kingdom. AIDS 1998; 12: 956-8

Gray R, Clarke M, Peto R, Richards S, Wheatley K, Masera G, Allan N, Montserrat E, Maclennan I, Burnett A, Henry-Amar M. Systematic overviews of randomised controlled trials in the treatment of colorectal cancer, leukaemia, myeloma and lymphoma. In: Baig SS (ed). Cancer Research Supported under BIOMED 1. Biomedical & Health Research, vol 24. IOS Press, 1998

Grimwade D, Walker H, Oliver F, Wheatley K, Harrison C, Harrison G, Rees J, Hann I, Stevens R, Burnett A, Goldstone A for the Medical Research Council Adult and Chldren's Leukaemia Working Parties. The importance of diagnostic cytogenetics on outcome in AML: analysis of 1612 patients entered into the MRC AML10 trial. Blood 1998; 92: 2322-33

Hann IM, Richards SM, Eden OB, Hill FGH on behalf of the Medical Research Council Childhood Leukaemia Working Party. Analysis of the immunophenotype of children treated on the Medical Research Council United Kingdom Acute Lymphoblastic Leukaemia Trial XI (MRC UKALLXI). Leukemia 1998; 12: 1249-55

Homocysteine Lowering Trialists' Collaboration (writing committee: Clarke R, Frost C, Leroy V, Collins R). Lowering blood homocysteine with folic acid based supplements: meta-analysis of randomised trials. BMJ 1998; 316: 894-8

Hu GZ, Zhang X, Chen JS, Peto R, Campbell TC, Cassano PA. Dietary vitamin C intake and lung function in rural China. Am J Epidemiol 1998; 148: 594-9

Kalra P, Baigent C. A proposed UK multicentre trial in ARVD. Br J Renal Med 1998; 3: 9

Liu BQ, Peto R, Chen ZM, Boreham J, Wu YP, Li JY, Campbell TC, Chen JS. Emerging tobacco hazards in China: 1. Retrospective proportional mortality study of one million deaths. BMJ 1998; 317: 1411-22

Malacrida R, Genoni M, Maggioni AP, Spataro V, Parish S, Palmer A, Collins R, Moccetti T for the Third International Study of Infarct Survival Collaborative Group. A comparison of the early outcome of acute myocardial infarction in women and men. N Eng J Med 1998; 338: 8-14

Meade TW, Gray R, Peto R. What we need to know and how to achieve it. In: Meade T (ed). Science-based Complementary Medicine. Royal College of Physicians 1998, pp.1-6

Melville A, Sheldon TA, Gray R, and Sowden A. Management of colorectal cancer. Quality in Health Care 1998; 7: 103-8

Myeloma Trialists' Collaborative Group (secretariat: Alison R, Clarke M, Evans V, Gray R, Greaves E, Hall E, Hicks C, James S, Peto R, Richards S, Sinclair D, Tooth A, Wheatley K). Combination chemotherapy versus melphalan plus prednisone as treatment for multiple myeloma: an overview of 6,633 patients from 27 randomized trials. J Clin Oncol 1998; 16: 3832-42

Niu SR, Yang GH, Chen ZM, Wang JL, Wang GH, He XZ, Schoepff H, Boreham J, Pan HC, Peto R. Emerging tobacco hazards in China: 2. Early mortality results from a prospective study. BMJ 1998; 317: 1423-4

Peto R, Baigent C. Trials: the next 50 years. BMJ 1998; 317: 1170-1

Peto R. Mortality from breast cancer in UK has decreased suddenly (letter). BMJ 1998; 317: 476-7

Rea D, Poole C, Gray R. Tamoxifen: how long before we know how long? (letter) BMJ 1998; 316: 1518-19

Reeves GK, Cox DR, Darby SC, Whitley E. Some aspects of measurement error in explanatory variables for continuous and binary regression models. Stat Med 1998; 17: 2157-77

Report of the Scientific Committee on Tobacco and Health (R Peto: member). London, HM Stationery Office, 1998

Richards S, Burrett J, Hann I, Chessells J, Hill F, Bailey C for the MRC Working Party on Childhood Leukaemia. Improved survival with early intensification: combined results from the Medical Research Council childhood ALL randomised trials, UKALL X and UKALL XI. Leukaemia 1998; 12: 1031-6

Rotchell YE, Cruickshank JK, Phillips GM, Griffiths J, Stewart A, Farrell B, Ayers S, Hennis A, Grant A, Duley L, Collins R. Barbados Low-dose Aspirin Study in Pregnancy (BLASP): a randomised trial for the prevention of pre-eclampsia and its complications. Br J Obs Gynae 1998; 105:286-92

Sitas F, Pacella-Norman R, Peto R, Collins R, Bradshaw D, Kleinschmidt I, Kielkowski D, Saloojee Y, Yach D, Lopez A, Bah S. Why do we need a large study on tobacco-attributed mortality in South Africa? (letter). S Afr Ned H 1998; 88: 925-6

Sonksen J, Gray R, Hutton P. Safer non-cardiac surgery for patients with coronary artery disease. BMJ 1998; 317: 1630-1

Specht L, Gray RG, Clarke MJ, Peto R for the International Hodgkin's Disease Collaborative Group. Influence of more extensive radiotherapy and adjuvant chemotherapy on long-term outcome of early-stage Hodgkin's disease: a meta-analysis of 23 randomized trials involving 3,888 patients. J Clin Oncol 1998; 16: 830-43

Stevens RF, Hann IM, Wheatley K, Gray R for the MRC Childhood Leukaemia Working Party. Marked improvements in outcome with chemotherapy alone in paediatric acute myeloid leukaemia: results of the United Kingdom Medical Research Council's 10^th AML Trial. Br J Haematol 1998; 101: 130-40

Tang JL, Armitage JM, Lancaster T, Silagy CA, Fowler GH, Neil HAW. Systematic review of dietary intervention trials to lower blood cholesterol in free-living subjects. BMJ 1998; 316: 1213-20

Vora A, Frost L, Goodeve A, Wilson G, Ireland RM, Lilleyman J, Eden T, Peake I, Richards S. Late relapsing childhood lymphoblastic leukemia. Blood 1998; 7: 2334-7

Wheatley K. Myeloma Trialists' Collaborative Group Meta-Analysis on Interferon. Cancer Research Therapy & Control 1998; 6: 145-8

Wheeler K, Richards S, Bailey C, Chessells J for the MRC Working Party on Childhood Leukaemia. Comparison of bone marrow transplant and chemotherapy for relapsed childhood acute lymphoblastic leukaemia -- the MRC UKALL X experience. Br J Haematol 1998; 101: 93-102

World Health Organization-International Society of Hypertension Blood Pressure Lowering Treatment Trialists' Collaboration (writing committee: MacMahon S, Neal B, Rodgers A, Baigent C, Collins R). Protocol for prospective collaborative overviews of major randomized trials of blood-pressure-lowering treatments. J Hypertension 1998; 16: 127-37

Publications in 1997

Ad Hoc Subcommittee of the Liaison Committee of the World Health Organization (writing committee: MacMahon S, Chalmers J, Collins R). Effects of calcium antagonists on the risks of coronary heart disease, cancer and bleeding. J Hypertension 1997; 15: 105-15

Baigent C. The need for large-scale randomised evidence. Br J Clin Pharm 1997; 43: 349-53

Born GV, Collins R. Aspirin versus clopidogrel: the wrong question? (letter). Lancet 1997; 349: 806-7

Bridgman S, Elder J, Gray R, Lilford R. Funding is important for randomised trials of surgery (letter). BMJ 1997; 315: 310

CAST (Chinese Acute Stroke Trial) Collaborative Group (writing committee: Chen ZM, Collins R, Liu LS, Pan HC, Peto R, Xie JX). CAST: randomised placebo-controlled trial of early aspirin use in 20,000 patients with acute ischaemic stroke. Lancet 1997; 349: 1641-9

Chen Z, Xu Z, Collins R, Li W, Peto R. Early health effects of the emerging tobacco epidemic in China. JAMA 1997; 278: 1500-4

Chen ZM, Collins R, Peto R, Xie JX, Liu LS on behalf of the CAST Collaborative Group. Interpretation of IST and CAST stroke trials (letter). Lancet 1997; 350: 444

Chen ZM, Sandercock P, Xie JX, Peto R, Collins R, Liu LS. Hospital management of acute ischaemic stroke in China. J Stroke Cerebrovasc Dis 1997; 6: 361-7

Chessells JM, Harrison G, Lilleyman JS, Bailey CC, Richards SM on behalf of the MRC Working Party for Childhood Leukaemia. Continuing (maintenance) therapy in lymphoblastic leukaemia: lessons from MRC UKALL X. Br J Haematol 1997; 98: 945-51

Chessells JM, Swansbury GJ, Reeves B, Bailey CC, Richards SM on behalf of the MRC Working Party on Childhood Leukaemia. Cytogenetics and prognosis in childhood lymphoblastic leukaemia: results of MRC UKALL X. Br J Haematol 1997; 99: 93-100

Chinese Cardiac Study Collaborative Group (writing committee: Liu LS, Wang W, Tao SQ, Chen ZM, Peto R, Collins R). Final results of First Chinese Cardiac Study (CCS-1) of oral captopril versus placebo among 14,962 patients with suspected acute myocardial infarction. Chinese J Cardiology 1997; 25: 245-51

Chronic Myeloid Leukaemia Trialists' Collaborative Group (writing committee: Richards S, Allan N, Clarke M, Gray R, Peto R). Interferon alfa versus chemotherapy for chronic myeloid leukemia: a meta-analysis of seven randomized trials. J Natl Cancer Inst 1997; 89: 1616-20

Clarke M, Ghersi D. Meta-analysis, collaborative overview, systematic review: what does it all mean? Australian Prescriber 1997; 20: 93-6

Clarke M, Greaves L, James S. MeSH terms must be used in Medline searches (letter). BMJ 1997; 314: 1203

Clarke M. Principles of systematic reviews of controlled trials. In: Fracchia GN, Haavisto KH (eds). European Medicines Research: Perspectives in Clinical Trials. 1996, 25-9

Clarke M. Value of ovariectomy as part of adjuvant therapy for breast cancer. Oncol Haematol 1997; 4: 4-5

Clarke MJ, Stewart LA. Meta-analyses using individual patient data. J Eval Clin Prac 1997; 3: 207-12

Clarke R, Frost C, Collins R, Appleby P, Peto R. Dietary lipids and blood cholesterol: quantitative meta-analysis of metabolic ward studies. BMJ 1997; 314: 112-17

Collaborative Group on Hormonal Factors in Breast Cancer (analysis & writing committee: Beral V, Bull D, Doll R, Key T, Peto R, Reeves G). Breast cancer and hormone replacement therapy: collaborative reanalysis of data from 51 epidemiological studies of 52,705 women with breast cancer and 108,411 women without breast cancer. Lancet 1997; 350: 1047-59

Collins R, Baigent C, Peto R. Reduced intensity of anticoagulation may be indicated (letter). BMJ 1997; 314: 222-3

Collins R, Peto R, Baigent C, Sleight P. Aspirin, heparin, and fibrinolytic therapy in suspected acute myocardial infarction. N Engl J Med 1997; 336: 847-60

Collins R, Peto R, Gray R, Parish S. Large-scale randomised evidence: trials and overviews. In: Maynard A, Chalmers I (eds). Non-Random Reflections on Health Services Research: On the 25th Anniversary of Archie Cochrane's Effectiveness and Efficiency. BMJ Publishing Group, London, 1997

Collins R, Peto R. Magnesium in acute myocardial infarction (letter). Lancet 1997; 349: 282-3

Consensus Statement: Prevention of venous thromboembolism (R Collins: member of Editorial Committee). International Angiology 1997; 16: 3-38

Danesh J, Collins R, Peto R. Chronic infections and coronary heart disease: is there a link? Lancet 1997; 350: 430-6

Danesh J, Newton R, Beral V. A human germ project? Nature 1997 389, 21-4

Danesh J. H pylori and diabetes (letter). Dig Dis Sci 1997; 42: 2576

Darby SC, Ewart DW, Giangrande PL, Spooner RJD, Rizza CR, Dusheiko GM, Lee CA, Ludlam CA, Preston FE for the UK Haemophilia Centre Directors' Organisation. Mortality from liver cancer and liver disease in haemophilic men and boys in UK given blood products contaminated with hepatitis C. Lancet 1997; 350: 1425-31

Darby SC, Whitley E, Reeves GK, Cox DR. The importance of accounting for uncertainties in the determination of radon concentrations in studies of the carcinogenic effects of residential radon exposure. In: Health Effects of Low Dose Radiation: Challenges of the 21st Century. London, British Nuclear Energy Society, 1997, pp.96-9

Darby SC. HIV-1 infection in the UK haemophilia population: a unique picture of the effects of a devastating virus. In: Bulletin of the International Statistical Institute. Proceedings of the 51st Session, 1997, pp.11-14

Davies C, Nomura Y, Ohashi Y. Adjuvant tamoxifen duration: more large scale randomised evidence is needed. Gan to Kagaku Ryoho (Japanese Journal of Cancer & Chemotherapy) 1997; 24: 1203-9

Doll R. A reminiscence of Archie Cochrane. In: Maynard A, Chalmers I (eds). Non-random Reflections on Health Services Research. BMJ Publishing Group, London, 1997, pp.7-10

Doll R. Alcohol and the reduction of mortality. Klinik und Forschung 1997; 3: 8-9

Doll R. Cochrane and the benefits of wine. In: Maynard A, Chalmers I (eds). Non-random Reflections on Health Services Research. BMJ Publishing Group, London, 1997, pp.58-74

Doll R. Effects of small doses of ionizing radiation on human health. Health effects of low dose radiation, pp. 1-7, Thomas Telford Publishing, London, 1997; and also Nuclear Energy 1997, 36, 435-41

Doll R. One for the heart. BMJ 1997; 315: 1664-8

Doll R. Tobaksrkning -- trefaldigt okad ddsrisk. In: Steineck G (ed). Lngre liv och bttre hlsa. Folk Halso Institutet, Stockholm, 1997

Doll R. Weak associations in epidemiology: importance, detection and interpretation. J Epidemiol 1997; 6 (Supplement): S11-20

Doll R, Darby S, Whitley E. Trends in mortality from smoking-related diseases. In: Charlton J, Murphy M (eds). The Health of Adult Britain 1841-1994, Vol 1. The Stationery Office, London, 1997, pp.128-55

Doll R, Peto R, Hall E, Wheatley K, Gray R. Alcohol and coronary heart disease reduction among British doctors: confounding or causality? Eur Heart J 1997; 18: 23-5

Doll R, Wakeford R. Risk of childhood cancer from fetal irradiation. Br J Radiol 1997; 70: 130-9

Durrant IJ, Prentice HG, Richards SM for the Medical Research Council Working Party on Leukaemia in Adults. Intensification of treatment for adults with acute lymphoblastic leukaemia: results of UK Medical Research Council randomised trial UKALL XA. Br J Haematol 1997; 99: 84-92

Grimwade D, Walker H, Oliver F, Wheatley K, Clack R, Burnett A, Goldstone A for the Medical Research Council Leukaemia Working Parties. What happens subsequently in AML when cytogenetic abnormalities persist at bone marrow harvest? Results of the 10th UK MRC AML trial. Bone Marrow Transplant 1997; 19: 1117-23

Hann IM, Stevens RF, Goldstone AH, Rees JK, Wheatley K, Gray RG, Burnett AK for the Adult and Childhood Leukaemia Working Parties of the Medical Research Council. Randomized comparison of DAT versus ADE as induction chemotherapy in children and younger adults with acute myeloid leukemia. Results of the Medical Research Council's 10^th AML trial (MRC AML10). Blood 1997; 89: 2311-18

Harris A, Danesh J, Forman D. (1997) Helicobacter pylori infection (letter). Lancet 1997; 349: 879-80

International Stroke Trial Collaborative Group (writing committee: Sandercock P, Collins R, Counsell C, Farrell B, Peto R, Slattery J, Warlow C). The International Stroke Trial (IST): a randomised trial of aspirin, subcutaneous heparin, both, or neither among 19,435 patients with acute ischaemic stroke. Lancet 1997; 349: 1569-81

Langabeer SE, Walker H, Gale RE, Wheatley K, Burnett AK, Goldstone AH, Linch DC for the MRC Adult Leukaemia Working Party. Frequency of CBF beta/MYH11 fusion transcripts in patients entered into the U.K. MRC AML trials. Br J Haematol 1997; 96: 736-9

Langabeer SE, Walker H, Rogers JR, Burnett AK, Wheatley K, Swirsky D, Goldstone AH, Linch DC for the MRC Adult Leukaemia Working Party. Incidence of AML1/ETO fusion transcripts in patients entered into the MRC AML trials. Br J Haematol 1997; 99: 925-8

Lilleyman JS, Gibson BE, Stevens RF, Will AM, Hann IM, Richards SM, Hill FGH on behalf of the MRC Working Party on Childhood Leukaemia. Clearance of marrow infiltration after 1 week of therapy for childhood lymphoblastic leukaemia: clinical importance and the effect of daunorubicin. Br J Haematol 1997; 97: 603-6

Liver Infusion Meta-analysis Group (writing committee: Gray R, Clarke M, Collins R, Peto R, Piedbois P, Mondor H, Buyse M). Portal vein chemotherapy for colorectal cancer: a meta-analysis of 4000 patients in 10 studies. J Natl Cancer Inst 1997; 89: 497-505

MacMahon S, Collins R, Chalmers J. Reliable and unbiased assessment of the effects of calcium antagonists: importance of minimizing both systematic and random errors. J Hypertension 1997; 15: 1201-4

Meade TW, Wald N, Collins R. CONSORT statement on the reporting standards of clinical trials. Recommendations are inappropriate for trial reports (letter). BMJ 1997; 314: 1126-7

Medical Research Council Prostate Cancer Working Party Investigators Group. Immediate versus deferred treatment for advanced prostatic cancer: initial results of the Medical Research Council trial. Br J Urol 1997; 79: 235-46

Mitropoulos KA, Armitage JM, Collins R, Reeves BEA, Meade TW, Wallendszus KR, Wilson SS, Lawson A, Peto R for the Oxford Cholesterol Study Group. Randomized placebo-controlled study of the effects of simvastatin on haemostatic variables, lipoproteins and free fatty acids. Eur Heart J 1997; 18: 235-41

Northover J, Meadows H, Ryan C, Gray R. Combined radiotherapy and chemotherapy for anal cancer (letter). Lancet 1997; 349: 205-6

Peto R, Collins R, Sackett D, Darbyshire J, Babiker A, Buyse M, Stewart H, Baum M, Goldhirsch A, Bonadonna G, Valagussa P, Rutqvist L, Elbourne D, Altman D, Dalesio O, Parmar M, Hill C, Clarke M, Gray R, Doll R. The trials of Dr Bernard Fisher: a European perspective on an American episode. Controlled Clinical Trials 1997; 18: 1-13

Peto R, Doll R. There is no such thing as aging. BMJ 1997; 315: 1030-2

Peto R. Birthweight as risk factor for breast cancer (letter). Lancet 1997; 349: 501

Peto R. Smoking and Alzheimer's disease (letter). Lancet 1997; 350: 295

Peto R. Towards a healthier planet. Odyssey 1997; 3: 56-7

Reperfusion Therapy Consensus Group (writing committee: Boersma H, Califf R, Collins R, Deckers JW, Simoons ML). Selection of reperfusion therapy for individual patients with evolving myocardial infarction. Eur Heart J 1997; 18: 1371-81

Richards SM. Interferon-a: results from randomized trials. In: Goldman JM (ed). Clinical Haematology, Chronic Myeloid Leukaemia, Vol 10, No. 2, Baillire Tindall, London, 1997, p.307-18

Rigg JA, Jamrozik K, Clarke M. How can we demonstrate that new developments in anesthesia are of real clinical importance? Anesthesiology 1997; 86: 1008-10

Secker-Walker LM, Prentice HG, Durrant J, Richards S, Hall E, Harrison G on behalf of the MRC Adult Leukaemia Working Party. Cytogenetics adds independent prognostic information in adults with acute lymphoblastic leukaemia on MRC trial UKALL XA. Br J Haematol 1997; 96: 601-10

Swerdlow A, Doll R, Dos Santos Silva I. Time trends in cancer incidence and mortality in England & Wales. In: Charlton J, Murphy M (eds). The Health of Adult Britain 1841-1994. Vol 1. The Stationery Office, London, 1997, pp.30-59

Thun MJ, Peto R, Lopez AD, Monaco JH, Henley SJ, Heath CW Jr, Doll R. Alcohol consumption and mortality among middle-aged and elderly US adults. N Engl J Med 1997; 337: 1705-14

Wakeford R, Doll R, Bithell JF. Childhood cancer and intrauterine irradiation. Health effects of low dose radiation,, Thomas Telford Publishing, London, 1997, pp.114-19

White HD, Aylward PE, Frey MJ, Adgey AAJ, Nair R, Hillis WS, Shalev Y, Brown MD, French JK, Collins R, Maraganore J, Adelman A on behalf of the Hirulog Early Reperfusion/Occlusion (HERO) Trial Investigators. Randomized, double-blind comparison of hirulog versus heparin in patients receiving streptokinase and aspirin for acute myocardial infarction (HERO). Circulation 1997; 96: 2155-61

Publications in 1996

Anderson P, Casswell S, Shaper AG, Rehm J, Bondy S, Doll R. Guidelines on sensible drinking. Addiction 1996; 91: 25-33

Childhood ALL Collaborative Group (writing committee: Richards S, Gray R, Peto R, Gaynon P, Masera G). Duration and intensity of maintenance chemotherapy in acute lymphoblastic leukaemia: overview of 42 trials involving 12,000 randomised children. Lancet 1996; 347: 1783-8

Clarke M. Early controlled trials: ... but "quasirandom allocation" of treatment was reported in 1930 (letter). BMJ 1996; 312: 1298

Collaborative Group on Hormonal Factors in Breast Cancer (analysis & writing committee: Beral V, Bull D, Reeves G, Peto R). Breast cancer and hormonal contraceptives: collaborative reanalysis of individual data on 53,297 women with breast cancer and 100,239 women without breast cancer from 54 epidemiological studies. Lancet 1996; 347: 1713-27

Collaborative Group on Hormonal Factors in Breast Cancer (analysis & writing committee: Beral V, Bull D, Reeves G, Peto R). Breast cancer and hormonal contraceptives: further results. Contraception 1996; 54 (Suppl): 1S-106S

Collins R, Baigent C, Peto R. Benefit of heparin plus aspirin vs aspirin alone in unstable angina (letter). JAMA 1996; 276: 1873

Collins R, MacMahon S, Flather M, Baigent C, Remvig L, Mortensen S, Appleby P, Godwin J, Yusuf S, Peto R. Clinical effects of anticoagulant therapy in suspected acute myocardial infarction: systematic overview of randomised trials. BMJ 1996; 313: 652-9

Collins R, Peto R. Magnesium therapy in acute myocardial infarction (letter). Am J Cardiol 1996; 77: 329

Collins R, Peto R, Gray R, Parish S. Large-scale randomized evidence: trials and overviews. In: In: Weatherall D, Ledingham JGG, Warrell DA (eds). Oxford Textbook of Medicine. Oxford University Press 1996, pp.21-32

Danesh J, Forman D, Collins R, Peto R. Helicobacter pylori screening and gastric cancer (letter). Lancet 1996; 348: 758-9

Darby SC, Ewart DW, Giangrande PLF, Spooner RJD, Rizza CR for the UK Haemophilia Directors Organisation. Importance of age at infection with HIV-1 for survival and development of AIDS in the UK haemophilia population. Lancet 1996; 347: 1573-80

Darby SC, Roman E. Links in childhood leukaemia. Nature 1996; 382: 303-4

Davies C, Gray R. The optimal duration of adjuvant tamoxifen: the still unanswered question. Nowotwory 1996; 3: 474-83

Doll R. A tentative estimate of the leukaemogenic effect of test thermonuclear explosions. J Radiol Prot 1996; 16: 3-5

Doll R. Cancers weakly related to smoking. Br Med Bull 1996; 52: 35-49

Doll R. Epidemiological evidence of hazard. Radiat Prot Dosim 1996; 68: 97-103

Doll R. Nature and nurture: possibilities for cancer control. Carcinogenesis 1996; 17: 177-84

Doll R. The beneficial effects of alcohol on vascular disease (contribution to discussion of BMA's guidelines on sensible drinking). Addiction 1996; 91: 32-3

Doll R. Trends in adolescent cancer with time. In: Selby P, Bailey C (eds): Cancer and the Adolescent. BMJ Publishing Group, London, 1996, 30-6

Doll R, Crofton J (eds). Tobacco and Health. Br Med Bull 1996; 52: 1-227

Doll R, Peto R. Epidemiology of cancer. In: Weatherall D, Ledingham JGG, Warrell DA (eds). Oxford Textbook of Medicine, Volume 1. Oxford University Press 1996, pp.187-222

Earl H, Baker P, Kerr D, Lee M, Gray R, Baum M. Recruitment into studies assessing optimum duration of treatment must continue (letter). BMJ 1996 312; 1036-7

Early Breast Cancer Trialists' Collaborative Group (writing committee: Clarke M, Collins R, Davies C, Godwin J, Gray R, Peto R). Ovarian ablation in early breast cancer: overview of the randomised trials. Lancet 1996; 348: 1189-96

ECPPA Collaborative Group (writing committee: Atallah A, Collins R, Farrell B, Handoll H). ECPPA: randomised trial of low-dose aspirin for the prevention of maternal and fetal complications in high-risk pregnant women. Br J Obstet Gyn 1996; 103: 39-47

Gale RP, Horowitz MM, Rees JK, Gray RG, Oken MM, Estey, et al. Chemotherapy versus transplants for acute myelogenous leukemia in second remission. Leukemia 1996; 10: 13-19

Gray R, Meadows H, Northover J, et al for the UKCCCR anal cancer trial working party. Epidermoid anal cancer: results from the UKCCCR randomised trial of radiotherapy alone versus radiotherapy, 5-fluorouracil and mitomycin. Lancet 1996;348: 1049-54

Gray R, Northover J. Adjuvant treatment for colorectal cancer: concerns about chemotherapy are legitimate (letter). BMJ 1996; 312: 1417-18

Grimwade D, Howe K, Langabeer S, Davies L, Oliver F, Walker H, Swirsky D, Wheatley K, Goldstone A, Burnett A, Solomon E for the MRC Adult Leukaemia Working Party. Establishing the presence of the t(15;17) in suspected acute promyelocytic leukaemia: cytogenetic, molecular and PML immunofluorescence assessment of patients entered into the MRC ATRA trial. Br J Haematol 1996; 94: 557-73

Hennekens CH, Buring JE, Manson JE, Stampfer M, Rosner B, Cook NR, Belanger C, LaMotte F, Gaziano JM, Ridker PM, Willett W, Peto R. Lack of effect of long-term supplementation with beta carotene on the incidence of malignant neoplasms and cardiovascular disease. N Engl J Med 1996; 334: 1145-9

Hennekens CH, Buring JE, Peto R. Antioxidant vitamins, cancer, and cardiovascular disease (letter). N Engl J Med 1996; 335: 1067

International Stroke Trial Pilot Study Collaborative Group (writing committee: Lindley R, Sandercock P, Warlow C, Slattery J, Smith B, Collins R). Study design of the International Stroke Trial (IST), baseline data, and outcome in 984 randomised patients in the pilot study. J Neurology, Neurosurg Psychiatry 1996; 60: 371-6

Jamal R, Gale RE, Shaun N, Thomas B, Wheatley K, Linch DC. The retinoblastoma gene (rb1) in acute myeloid leukaemia: analysis of gene rearrangements, protein expression and comparison of disease outcome. Br J Haematol 1996; 94: 342-51

Keech AC, Armitage JM, Wallendszus KR, Lawson A, Hauer AJ, Parish SE, Collins R for the Oxford Cholesterol Study Group. Absence of effect of prolonged simvastatin therapy on nocturnal sleep in a large randomised placebo-controlled study. Br J Clin Pharm 1996; 42: 483-90

Kerr DJ, Gray R. Adjuvant chemotherapy for colorectal cancer. Br J Hosp Med 1996; 55: 259-62

Lehtinen M, Dillner J, Knekt P, Luostarinen T, Aromaa A, Kirnbauer R, Koskela P, Paavonen J, Peto R, Schiller JT, Hakama M. Serologically diagnosed infection with human papillomavirus type 16 and risk for subsequent development of cervical carcinoma: nested case-control study. BMJ 1996; 312: 537-9

Lopez AD, Peto R. The future effects of current smoking patterns: assessing the magnitude of the pandemic. In: Richmond R (ed). Educating Medical Students about Tobacco: Planning and Implementation. International Union Against Tuberculosis and Lung Disease, Paris, France, 1996

Mahaffey KW, Granger CB, Collins R, O'Connor CM, Ohman EM, Bleich SD, Col JJ, Califf RM. Overview of randomized trials of intravenous heparin in patients with acute myocardial infarction treated with thrombolytic therapy. Am J Cardiol 1996; 77: 551-6

Peto R. Clinical trial reporting (letter). Lancet 1996; 348: 894-5

Peto R, Chen Z, Boreham J. Tobacco -- the growing epidemic in China. JAMA 1996; 275: 1683-4

Peto R, Gray R, Collins R. Radiotherapy and surgery in early breast cancer (letter). N Engl J Med 1996; 334: 989

Peto R, Lopez AD, Boreham J, Thun M, Heath C Jr, Doll R. Mortality from smoking worldwide. Br Med Bull 1996; 52: 12-21

Peto R. Five years of tamoxifen -- or more?. J Natl Cancer Inst 1996; 88: 1791-1793

Porwit-MacDonald A, Janossy G, Ivory K, Swirsky D, Peters R, Wheatley K, Walker H, Turker A, Goldstone AH, Burnett A. Leukemia-associated changes identified by quantitative flow cytometry. IV. CD34 overexpression in acute myelogenous leukemia M2 with t(8;21). Blood 1996; 87: 1162-9

Qizilbash N, Lewington S, Peto R. Cholesterol and risk of stroke (letter). Lancet 1996; 347: 762

Rees JKH, Gray RG, Wheatley K for the MRC Leukaemia in Adults Working Party. Dose intensification in acute myeloid leukaemia: greater effectiveness at lower cost. Principal report of the Medical Research Council's AML9 study. Br J Haematol 1996; 94: 89-98

Taylor D, Kenyon S, Peto R, Tarnow-Mordi W. Preterm premature rupture of membranes (letter). Lancet 1996; 347: 204

Wardle J, Armitage J, Collins R, Wallendszus K, Keech A, Lawson A for the Oxford Cholesterol Study Group. Randomised placebo controlled trial of effect on mood of lowering cholesterol concentration. BMJ 1996; 313: 75-8

Watson M, Zittoun R, Hall E, Solbu G, Wheatley K. A modular questionnaire for the assessment of longterm quality of life in leukaemia patients: the MRC/EORTC QLQ-LEU. Quality of Life Research 1996; 5: 15-19

Wheeler K, Chessells JM, Bailey C, Richards SM on behalf of the MRC Working Party on Childhood Leukaemia. Treatment-related deaths during induction and in first remission in acute lymphoblastic leukaemia: MRC UKALL X. Archives of Disease in Childhood 1996; 74: 101-7

Publications in 1995

Advisory Group on Non-Ionising Radiation (Chairman: Doll R). Health effects from ultraviolet radiation. Documents of the NRPB, 6, No. 2, 7-190. National Radiological Protection Board, Didcot, 1995

Allan NC, Richards SM, Shepherd PCA on behalf of the MRC Working Party for Therapeutic Trials in Adult Leukaemia. UK Medical Research Council randomised multicentre trial of interferon-an1 for chronic myeloid leukaemia: improved survival irrespective of cytogenetic response. Lancet 1995; 345: 1392-7

Awasthi S, Peto R, Fletcher R, Glick H. Controlling parasitic infestation in children under five years of age: giving albendazole in conjunction with an Indian Government vitamin A supplement program. In: Treating Parasitic Infestations in Children, Monograph No. 3. INCLEN Monograph Series on Critical International Health Issues. Philadelphia, USA, 1995, pp.1-5

Beral V, Hermon C, Reeves G, Peto R. Sudden fall in breast cancer death rates in England and Wales (letter). Lancet 1995; 345: 1641-3

Buring JE, Hebert P, Romero J, Kittross A, Cook N, Manson J, Peto R, Hennekens C. Migraine and subsequent risk of stroke in the Physicians' Health Study. Arch Neurol 1995; 52: 129-34

Chen ZM, Shao YF. Colorectal cancer 5-FU portal-vein infusion trial: trial progress and baseline characteristics of the 3000 patients randomised during the first year of the trial. Chinese J Oncology 1995; 6: 467-9

Chen ZM, Shao YF. Randomised controlled trials: why do we need overviews? Chinese J Oncology 1995; 2: 125-7

Chessells JM, Bailey C, Richards S for the MRC Working Party on Childhood Leukaemia. Intensification of treatment and survival in all children with lymphoblastic leukaemia: results of UK Medical Research Council trial UKALLX. Lancet 1995; 345: 143-8

Chessells JM, Richards SM. Gender and treatment outcome in acute lymphoblastic leukaemia: report from the MRC UKALL trials. Br J Haematol 1995; 89: 364-72

Chinese Cardiac Study Collaborative Group (writing committee: Liu LS, Wang W, Pan XW, Chen ZM, Collins R, Peto R). Oral captopril versus placebo among 13,634 patients with suspected acute myocardial infarction: interim report from the Chinese Cardiac Study (CCS-1). Lancet 1995; 345: 686-7

Cholesterol Treatment Trialists (CTT) Collaboration (secretariat: Baigent C, Collins R, Keech A, Simes J). Protocol for a prospective collaborative overview of all current and planned randomized trials of cholesterol treatment regimens. Am J Cardiol 1995; 75: 1130-4

Clarke M, Greaves L. Identifying relevant studies for systematic reviews (letter). BMJ 1995; 310: 741

Clarke M, Stewart L. Systematic reviews of randomised controlled trials: the need for complete data. J Eval Clin Prac 1995; 1: 119-26

Collins R, Baigent C, Peto R. Effects of streptokinase in patients presenting within 6 hours of prolonged chest pain with ST segment depression (letter). Br Heart J 1995; 74: 573-4

Collins R, Peto R. Risks and benefits of calcium antagonists (letter). Lancet 1995; 346: 961-2

Collins R, Peto R, Sleight P for the ISIS Collaborative Group. ISIS-4 (letter). Lancet 1995; 345: 1374-5

Dalesio O, Peto R, Schrder F. Anti-androgens in treatment of prostate cancer (letter). Lancet 1995; 346: 1031

Darby SC, Doll R, Evans HJ. Paternal irradiation is not a material cause of childhood leukaemia. In: Sundnes G (ed). Biomedical and psychosocial consequences of radiation from man-made radionuclides in the biosphere. Royal Norwegian Society of Sciences and Letters Foundation, Trondheim, 1995, pp.283-301

Darby SC, Ewart W, Giangrande PLF, Dolin PJ, Spooner RJD, Rizza CR on behalf of the UK Haemophilia Centre Directors' Organisation. Mortality before and after HIV infection in the complete UK population of haemophiliacs. Nature 1995; 377: 79-82

Darby SC, Inskip P. Ionizing radiation: Future etiologic research and preventive strategies. Environ Hlth Perspect 1995; 103: 245-9

Darby SC, Radford EP, Whitley E. Radon exposure and cancers other than lung cancer in Swedish iron miners. Environ Hlth Perspect 1995; 103: 45-7

Darby SC, Roman E. Leukaemia and ionising radiation. Biol Sci Rev 1995; 7: 11-13

Darby SC, Weiss HA. Human studies in radiation leukaemogenesis. In: Hendry JH, Lord BI (eds). Radiation Toxicology: Bone Marrow & Leukaemia. London, Taylor & Francis, 1995, pp 335-53

Darby SC, Whitley E, Howe GR, Hutchings SJ, Kusiak RA, Lubin JH, Morrison HI, Tirmarche M, Tomsek L, Radford EP, Roscoe RJ, Samet JM, Xiang YS. Radon and cancers other than lung cancer in underground miners: a collaborative analysis of 11 studies. J Natl Cancer Inst 1995; 87: 378-84

Doll R. Assessment of risk from low doses: Contribution of epidemiology. Trans Inst Chem Engineers 1995; 73: S8-S11

Doll R. Effect of small doses. Nucl Energy 1995; 34: 15-19

Doll R. Hazards of ionizing radiation: 100 years of observation on Man. Br J Cancer 1995; 72: 1339-49

Doll R. Health effects of tobacco. In: Slama K (ed): Tobacco and Health. Plenum Press, New York, 1995, 81-5.

Doll R. Sir Austin Bradford Hill: a personal view of his contribution to epidemiology. J Roy Statist Soc A 1995; 158: 155-63

Doll R. Chronic and degenerative disease: major causes of morbidity and death. Am J Clin Nutr 1995; 62: 1301S-05S

Doll R, Peto R. Mortality and alcohol consumption (letter). BMJ 1995; 31: 470

Early Breast Cancer Trialists' Collaborative Group (secretariat: Clarke M, Collins R, Godwin J, Gray R, Peto R). Effects of radiotherapy and surgery in early breast cancer: an overview of the randomized trials. N Engl J Med 1995; 333: 1444-5

Gray R, Clarke M, Collins R, Peto R. La revisin del Early Breast Cancer Trialists' Collaborative Group (EBCTCG) sobre terapia adyuvante en cncer de mama: implicaciones frente a futuros estudios. Chapter 62 in: Mastologia Dinamica (ed E A Gardiol, A T Gomez). Ediciones Diaz de Santos SA, Madrid, 1995

Gray R, Clarke M, Collins R, Peto R. Making randomised trials larger: a simple solution? Eur J Surg Oncol 1995; 21: 137-9

Harris ML, Bron AJ, Brown NAP, Keech AC, Wallendszus KR, Armitage JA, MacMahon S, Snibson G, Collins R for the Oxford Cholesterol Study Group. Absence of effect of simvastatin on the progression of lens opacities in a randomised placebo controlled study. Br J Ophthalmol 1995; 79: 996-1002

ISIS-4 (Fourth International Study of Infarct Survival) Collaborative Group (writing committee: Collins R, Peto R, Flather M, Parish S, Sleight P). ISIS-4: A randomised factorial trial assessing early oral captopril, oral mononitrate, and intravenous magnesium sulphate in 58,050 patients with suspected acute myocardial infarction. Lancet 1995; 345: 669-85

Lee KS, Plowman PN, Gilmore OJ, Gray R: Tamoxifen in breast conservation therapy. Int J Clin Pharm Ther 1995; 33: 281-4

Lo YMD, Darby S, Noakes L, Whitley E, Silcocks PBS, Fleming KA, Bell JI. Screening for codon 249 p53 mutation in lung cancer associated with domestic radon exposure (letter). Lancet 1995; 345: 60

MacMahon S, Rodgers A, Collins R, Farrell B. Antiplatelet therapy to prevent thrombosis after hip fracture. J Bone Joint Surg 1995; 77-B: 163-4

Morris J, Densem JW, Wald NJ, Doll R. Occupational exposure to hydrazine and subsequent risk of cancer. Occup Environ Med 1995; 52: 43-5

Oxman AD, Clarke MJ, Stewart LA. From science to practice: meta-analyses using individual patient data are needed. JAMA 1995; 274: 845-6

Parish S, Collins R, Peto R, Youngman L, Barton J, Jayne K, Clarke R, Appleby P, Lyon V, Cederholm-Williams S, Marshall J, Sleight P for the International Studies of Infarct Survival (ISIS) Collaborators. Cigarette smoking, tar yields, and non-fatal myocardial infarction: 14,000 cases and 32,000 controls in the United Kingdom. BMJ 1995; 311: 471-7

Peto R, Collins R, Gray R. Large-scale randomized evidence: large, simple trials and overviews of trials. J Clin Epidemiol 1995; 48: 23-40

Peto R, Lopez AD, Boreham J, Thun M, Heath C Jr. Health effects of tobacco use: global estimates and projections. In: Tobacco and Health (ed Slama K): Proceedings of the Ninth World Conference on Tobacco and Health, Paris, 1994. Plenum Press, New York, 1995

Peto R. Clinical trials. In: Treatment of Cancer (ed Price P, Sikora K). Chapman & Hall, London, 1995

Peto R. The smoking and health tug of war: death from tobacco in Central Europe. Central European Health & Environment Monitor 1995; 3: 1-2

Peto R. Tobacco and premature death in the European Union. In: Cancer Research at the European Level (ed S S Baig). European Commission, IOS Press, Ohmsha, 1995

Pinel J, Fearn T, Darby SC, Miles JCH. Seasonal correction factors for indoor radon measurements in the United Kingdom. Radiat Prot Dosim 1995; 58: 127-32

Porwit-MacDonald A, Ivory K, Wilkinson S, Wheatley K, Wong L, Janossy G. Bcl-2 protein expression in normal bone marrow precursors and in acute myelogenous leukemia. Leukemia 1995; 9: 1191-8

Prospective Studies Collaboration (writing committee: Qizilbash N, Lewington S, Duffy S, Peto R). Cholesterol, diastolic blood pressure, and stroke: 13,000 strokes in 450,000 people in 45 prospective cohorts. Lancet 1995; 346: 1647-53

Prostate Cancer Trialists' Collaborative Group (writing committee: Dalesio O, Schrder F, Peto R). Maximum androgen blockade in advanced prostate cancer: an overview of 22 randomised trials with 3283 deaths in 5710 patients. Lancet 1995; 346: 265-9

Richards SM. Meta-analyses and overviews of randomised trials. Blood Reviews 1995; 9: 85-91

Rong WJ, Yan YJ, Shao YF, Chen ZM. Issues in the long term follow-up of cancer trials. Chinese J Oncology 1995; 4: 319-20

Shao YF, Chen ZM, Shan Y. Randomised controlled trials: design, conduct and progress of the Oxford/China early breast cancer trial of ovarian ablation and surgical options in China. Chinese J Oncology 1995; 1: 74-6

Stewart L, Clarke M, for the Cochrane Collaboration Working Group on Meta-Analyses Using Individual Patient Data. Practical methodology of meta-analyses (overviews) using updated individual patient data. Stat Med 1995; 14: 2057-79

Tomsek L, Darby SC. Recent results from the study of West Bohemian uranium miners exposed to radon and its progeny. Environ Hlth Perspect 1995; 103: 55-7

Wang X, Shao YF, Chen ZM, Wu TC. Adjuvant treatments for early breast cancer. I: Hormonal treatment. Chinese J Oncology 1995; 3: 229-32

Wang X, Shao YF, Chen ZM, Wu TC. Adjuvant treatments for early breast cancer. II: Chemotherapy. Chinese J Oncology 1995; 4: 316-18

Weiss HA, Darby SC, Fearn T, Doll R. Leukaemia mortality following x-ray treatment for ankylosing spondylitis. Radiation Res 1995; 142: 1-11

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