Selected references to CTSU work
| 1. | Peto R, Pike MC, Armitage P, et al. Design and analysis of randomized clinical trials requiring prolonged observation of each patient. Part I: Introduction and design. Br J Cancer 1976; 34: 585-612. |
| 2. | Peto R, Pike MC, Armitage P, et al. Design and analysis of randomized clinical trials requiring prolonged observation of each patient. Part II: Analysis and examples. Br J Cancer 1977; 35: 1-39 |
| 3. | Yusuf S, Collins R, Peto R. Why do we need some large simple randomized trials. Stat Med 1984; 3: 409-420 |
| 4. | Collins R, Gray R, Godwin J, Peto R. Avoidance of large biases and large random errors in the assessment of moderate treatment effects: the need for systematic overviews. Stat Med 1987; 6: 245-250 |
| 5. | Collins R, Peto R, Gray R, Parish S. Large-scale randomized evidence: trials and overviews. In: Oxford Textbook of Medicine (eds Weatherall D, Ledingham JGG, Warrell DA). Oxford University Press 1996 |
| 6a. | Early Breast Cancer Trialists' Collaborative Group. Effects of adjuvant tamoxifen and of cytotoxic therapy on mortality in early breast cancer: an overview of 61 randomized trials among 28,896 women. N Engl J Med 1988; 319: 1681-1691 |
| 6b. | Early Breast Cancer Trialists' Collaborative Group. Treatment of early breast cancer. Vol. I: Worldwide evidence 1985-1990. Oxford University Press, 1990 |
| 7a. | Early Breast Cancer Trialists' Collaborative Group. Systemic treatment of early breast cancer by hormonal, cytotoxic, or immune therapy: 133 randomised trials involving 31,000 recurrences and 24,000 deaths among 75,000 women. Lancet 1992; 339: 1-15 & 71-85 |
| 7b. | Early Breast Cancer Trialists' Collaborative Group. Effects of radiotherapy and surgery in early breast cancer: an overview of the randomized trials. N Engl J Med 1995; 333: 1444-1455 |
| 7c. | Early Breast Cancer Trialists' Collaborative Group. Ovarian ablation in early breast cancer: overview of the randomised trials. Lancet 1996; 348: 1189-1196 |
| 7d. | Early Breast Cancer Trialists' Collaborative Group. Tamoxifen for early breast cancer: an overview of the randomised trials. Lancet 1998; 351: 1451-1467 |
| 7e. | Early Breast Cancer Trialists' Collaborative Group. Polychemotherapy for early breast cancer: an overview of the randomised trials. Lancet 1998; 352: 930-942 |
| 7f. | Early Breast Cancer Trialists' Collaborative Group. Favourable and unfavourable effects on long-term survival of radiotherapy for early breast cancer: an overview of the randomised trials. Lancet 2000; 355: 1757-70 |
| 8 | Adjuvant Theapy for Breast Cancer. NIH Consensus Statement 2000 November 1-3;17(4): 1-23 |
| 9a. | Early Breast Cancer Trialists' Collaborative Group (EBCTCG). Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival: an overview of the randomised trials. Lancet 2005; 365: 1687-1717 |
| 9b. | Early Breast Cancer Trialists' Collaborative Group (EBCTCG). Effects of radiotherapy and of differences in the extent of surgery for early breast cancer on local recurrence and on 15-year survival: an overview of the randomised trials. Lancet 2005; 366: 2087-2106 |
| 10a. | Early Breast Cancer Trialists' Collaborative Group (EBCTCG). Adjuvant chemotherapy in oestrogen-receptor-poor breast cancer: patient-level meta-analysis of randomised trials. Lancet 2008; 371: 29-40 |
| 10b. | Early Breast Cancer Trialists' Collaborative Group (EBCTCG). Overview of the randomized trials of radiotherapy in ductal carcinoma in situ of the breast. JNCI Monographs 2010, 41: 162-177 |
| 10c. | Dowsett M, Cuzick J, Ingle, J, Coates A, Forbes J, Bliss J, Buyse M, Baum M, Buzdar A, Colleoni M, Coombes C, Snowdon C, Gnant M, Jakesz R, Kaufmann M, Boccardo F, Godwin J, Davies C, Peto R. Meta-analysis of breast cancer outcomes in adjuvant trials of aromatase inhibitors versus tamoxifen. J Clin Oncol 2010; 28: 509-518 |
| 10d. | Early Breast Cancer Trialists’ Collaborative Group (EBCTCG). Relevance of breast cancer hormone receptors and other factors to the efficacy of adjuvant tamoxifen: patient-level meta-analysis of randomised trials. Lancet 2011; 378: 771-84 DOI: 10.1016/S0140-6736(11)60993-8 |
| 10e. | Early Breast Cancer Trialists’ Collaborative Group (EBCTCG). Effect of radiotherapy after breast-conserving surgery on 10-year recurrence and 15-year breast cancer death: meta-analysis of individual patient data for 10 801 women in 17 randomised trials. Lancet 2011; 378: 1707-60 DOI: 10.1016/S0140-6736(11)61629-2 |
| 10f. | Comparisons between different polychemotherapy regimens for early breast cancer: meta-analyses of long-term outcome in 100,000 randomised women in 123 randomised trials Lancet 2012; 379: 432-44 DOI:10.1016150140-6736(11) 61625-5 |
| 14. | ISIS-1 (First International Study of Infarct Survival) Collaborative Group. Randomised trial of intravenous atenolol among 16,027 cases of suspected acute myocardial infarction: ISIS-1. Lancet 1986; ii: 57-66 |
| 15. | ISIS-2 (Second International Study of Infarct Survival) Collaborative Group. Randomised trial of intravenous streptokinase, oral aspirin, both, or neither among 17,187 cases of suspected acute myocardial infarction: ISIS-2. Lancet 1988; ii: 349-360 |
| 16. | ISIS-3 (Third International Study of Infarct Survival) Collaborative Group. ISIS-3: A randomised trial of streptokinase vs tissue plasminogen activator vs anistreplase and of aspirin plus heparin vs aspirin alone among 41,299 cases of suspected acute myocardial infarction. Lancet 1992; 339: 753-770 |
| 17. | ISIS-4 (Fourth International Study of Infarct Survival) Collaborative Group. ISIS-4: A randomised factorial trial assessing early oral captopril, oral mononitrate, and intravenous magnesium sulphate in 58,050 patients with suspected acute myocardial infarction. Lancet 1995; 345: 669-685 |
| 18. | Peto R, Lopez AD, Boreham J, Thun M, Heath C. Mortality from tobacco in developed countries: indirect estimation from national vital statistics. Lancet 1992; 339: 1268-78 |
| 19. | Peto R, Lopez AD, Boreham J, Thun M, Heath C Jr. Mortality from Smoking in Developed Countries 1950-2000: Indirect Estimates from National Vital Statistics. Oxford University Press, 1994 |
| 20. | Peto R, Lopez AD, Boreham J, Thun M, Heath C Jr. Health effects of tobacco use: global estimates and projections. In: Tobacco and Health (ed Slama K): Proceedings of the Ninth World Conference on Tobacco and Health, Paris, 1994. Plenum Press, New York, 1995 |
| 21. | Peto R, Lopez AD, Boreham J, Thun M, Heath C Jr, Doll R. Mortality from smoking worldwide. Br Med Bull 1996; 52: 12-21 |
| 22. | MacMahon S, Peto R, Cutler J, Collins R, et al. Blood pressure, stroke, and coronary heart disease. Part I. Prolonged differences in blood pressure: prospective observational studies corrected for the regression dilution bias. Lancet 1990; 335: 765-774 |
| 23. | Prospective Studies Collaboration. Cholesterol, diastolic blood pressure, and stroke: 13,000 strokes in 450,000 people in 45 prospective cohorts. Lancet 1995; 346: 1647-1653 |
| 24. | Prospective Studies Collaboration. Collaborative overview ("meta-analysis") of prospective observational studies of the associations of usual blood pressure and usual cholesterol levels with common causes of death: protocol for the second cycle of the Prospective Studies Collaboration. J Cardiovasc Risk 1999; 6: 315-320 |
| 25. | Antiplatelet Trialists' Collaboration. Secondary prevention of vascular disease by prolonged antiplatelet therapy. BMJ 1988; 296: 320-331 |
| 26. | Antiplatelet Trialists' Collaboration. Collaborative overview of randomised trials of antiplatelet therapy. I: Prevention of death, myocardial infarction, and stroke by prolonged antiplatelet therapy in various categories of patients. BMJ 1994; 308: 81-106 |
| 27. | Antiplatelet Trialists' Collaboration. Collaborative overview of randomised trials of antiplatelet therapy. II: Maintenance of vascular graft or arterial patency by antiplatelet therapy. BMJ 1994; 308: 159-168 |
| 28. | Antiplatelet Trialists' Collaboration. Collaborative overview of randomised trials of antiplatelet therapy. III: Reduction in venous thrombosis and pulmonary embolism by antiplatelet prophylaxis among surgical and medical patients. BMJ 1994; 308: 235-246 |
| 29. | Fibrinolytic Therapy Trialists' Collaborative Group. Indications for fibrinolytic therapy in suspected acute myocardial infarction: collaborative overview of early mortality and major morbidity results from all randomised trials of more than 1000 patients. Lancet 1994; 343: 311-322 |
| 30. | Cholesterol Treatment Trialists' (CTT) Collaboration. Protocol for a prospective collaborative overview of all current and planned randomized trials of cholesterol treatment regimens. Am J Cardiol 1995; 75: 1130-1134 |
| 31. | Prostate Cancer Trialists' Collaborative Group. Maximum androgen blockade in advanced prostate cancer: an overview of 22 randomised trials with 3283 deaths in 5710 patients. Lancet 1995; 346: 265-269 |
| 32. | Prostate Cancer Trialists' Collaborative Group. Maximum androgen blockade in advanced prostate cancer: an overview of the randomised trials. Submitted to Lancet (1999) |
| 33. | Richards S, Peto R, Gray R for the Childhood ALL Collaborative Group. Duration and intensity of maintenance chemotherapy in acute lymphoblastic leukaemia: overview of 42 trials involving 12,000 randomised children. Lancet 1996; 347: 1783-1788 |
| 34. | CML Trialists' Collaborative Group. Interferon alpha versus chemotherapy for chronic myeloid leukemia: meta-analysis of seven randomized trials. J Natl Cancer Inst 1997; 89: 1616-1620 |
| 35. | Specht L, Gray RG, Clarke MJ, Peto R for the International Hodgkin's Disease Collaborative Group. Influence of more extensive radiotherapy and adjuvant chemotherapy on long-term outcome of early-stage Hodgkin's disease: a meta-analysis of 23 randomized trials involving 3,888 patients. J Clin Oncol 1998; 16: 830-843 |
| 36. | Myeloma Trialists' Collaborative Group. Combination chemotherapy versus melphalan plus prednisone as treatment for multiple myeloma: an overview of 6,633 patients from 27 randomized trials. J Clin Oncol 1998; 16: 3832-3842 |
| 37. | CLL Trialists' Collaborative Group. Chemotherapeutic options in chronic lymphocytic leukemia: a meta-analysis of the randomized trials. J Natl Cancer Inst 1999; 91: 861-868 |
| 38. | AML Collaborative Group. A systematic collaborative overview of randomised trials comparing idarubicin with daunorubicin (or other anthracyclines) as induction therapy for acute myeloid leukaemia. Br J Haematol 1998; 103: 100-109 |
| 39. | MRC/BHF Heart Protection Study Collaborative Group. MRC/BHF Heart Protection Study of cholesterol-lowering therapy and of antioxidant vitamin supplementation in a wide range of patients at increased risk of coronary heart disease death: early safety and efficacy experience. Eur Heart J 1999; 20: 725-741 |
| 40. | Danesh J, Lewington S. Plasma homocysteine and coronary heart disease: systematic review of published epidemiological studies. J Cardiovasc Risk 1998; 5: 229-232 |
| 41. | Homocysteine Lowering Trialists' Collaboration. Lowering blood homocysteine with folic acid based supplements: meta-analysis of randomised trials. BMJ 1998; 316: 894-898 |
| 42. | Clarke R, Collins R. Can dietary supplements with folic acid or vitamin B6 reduce cardiovascular risk? Design of clinical trials to test the homocysteine hypothesis of vascular disease. J Cardiovasc Risk 1998; 5: 249-255 |
| 43. | The Pulmonary Embolism Prevention (PEP) Trial Collaborative Group. Prevention of pulmonary embolism and deep vein thrombosis with low-dose aspirin in the randomised placebo-controlled Pulmonary Embolism Prevention trial. Lancet 1999 (accepted) |
| 44. | Collins R, Scrimgeour A, Yusuf S, Peto R. Reduction in fatal pulmonary embolus and in venous thrombosis by perioperative administration of subcutaneous heparin: overview of results of randomized trials in general, orthopedic and urologic surgery. New Engl J Med 1988; 318: 1162-1173 |
| 45. | Baigent C, Wheeler D, Burbury K. Premature cardiovascular disease in chronic renal failure. Lancet 2000; 356: 147-152 |
| 46. | Chinese Cardiac Study Collaborative Group. Oral captopril versus placebo among 13,634 patients with suspected acute myocardial infarction: interim report from the Chinese Cardiac Study (CCS-1). Lancet 1995; 345: 686-687 |
| 47. | CAST (Chinese Acute Stroke Trial) Collaborative Group. CAST: randomised placebo-controlled trial of early aspirin use in 20,000 patients with acute ischaemic stroke. Lancet 1997; 349: 1641-1649 |
| 48. | Peto R. Five years of tamoxifen -- or more? (Editorial). J Natl Cancer Inst 1996; 88: 1791-1793 |
| 49. | Liver Infusion Meta-analysis Group. Portal vein chemotherapy for colorectal cancer: a meta-analysis of 4000 patients in 10 studies. J Natl Cancer Inst 1997; 89: 497-505 |
| 50. | Chen ZM, Shao YF. Colorectal cancer 5-FU portal-vein infusion trial: trial progress and baseline characteristics of the 3000 patients randomised during the first year of the trial. Chinese J Oncol 1995; 6: 467-469 |
| 51. | Shao YF, Chen ZM, Shan Y. Randomised controlled trials: design, conduct and progress of the Oxford/China early breast cancer trial of ovarian ablation and surgical options in China. Chinese J Oncol 1995; 1: 74-76 |
| 52. | Sun Z, Zhu Y, Stjernsward J, Hilleman M, Collins R, Zhen Y, Hsia CC, Lu J, Huang F, Ni Z, Ni T, Chen JG, Yu Z, Liu Y, Liu G, Chen JM, Peto R. Design and compliance of HBV vaccination trial on newborns to prevent hepatocellular carcinoma and 5-year results of its pilot study. Cancer Detection & Prevention 1991; 15: 313-318 |
| 53. | Chessells JM, Eden OB, Bailey CC, Lilleyman JS, Richards SM. Acute lymphoblastic leukaemia in infancy: experience in MRC UKALL trials. Leukemia 1994; 8: 1275-1279 |
| 54. | Chessells JM, Bailey C, Richards S for the MRC Working Party on Childhood Leukaemia. Intensification of treatment and survival in all children with lymphoblastic leukaemia: results of UK Medical Research Council trial UKALL X. Lancet 1995; 345: 143-148 |
| 55. | Allan NC, Richards SM, Shepherd PCA on behalf of the MRC Working Party for Therapeutic Trials in Adult Leukaemia. UK Medical Research Council randomised multicentre trial of interferon-an1 for chronic myeloid leukaemia: improved survival irrespective of cytogenetic response. Lancet 1995; 345: 1392-1397 |
| 56. | Wheeler K, Chessells JM, Bailey C, Richards SM on behalf of the MRC Working Party on Childhood Leukaemia. Treatment-related deaths during induction and in first remission in acute lymphoblastic leukaemia: MRC UKALL X. Archives of Disease in Childhood 1996; 74: 101-107 |
| 57. | Rees JKH, Gray RG, Wheatley K on behalf of the MRC Leukaemia in Adults Working Party. Dose intensification in acute myeloid leukaemia: greater effectiveness at lower cost. Principal report of the Medical Research Council's AML9 study. Br J Haematol 1996; 94: 89-98 |
| 58. | Durrant IJ, Prentice HG, Richards SM for the Medical Research Council Working Party on Leukaemia in Adults. Intensification of treatment for adults with acute lymphoblastic leukaemia: results of UK Medical Research Council randomised trial UKALL XA. Br J Haematol 1997; 99: 84-92 |
| 59. | Chessells JM, Harrison G, Lilleyman JS, Bailey CC, Richards SM on behalf of the MRC Working Party for Childhood Leukaemia. Continuing (maintenance) therapy in lymphoblastic leukaemia: lessons from MRC UKALL X. Br J Haematol 1997; 98: 945-951 |
| 60. | Hann IM, Stevens RF, Goldstone AH, Rees JKH, Wheatley K, Gray RG, Burnett AK on behalf of the Adult and Childhood Leukaemia Working Parties of the Medical Research Council. Randomized comparison of DAT versus ADE as induction chemotherapy in children and younger adults with acute myeloid leukemia. Results of the Medical Research Council's 10th AML trial (MRC AML10). Blood 1997; 89: 2311-2318 |
| 61. | Burnett AK, Goldstone AH, Stevens RMF, Hann IM, Gray RG, Rees JKH, Wheatley K. The addition of autologous bone marrow transplantation to intensive chemotherapy for acute myeloid leukaemia in first remission significantly reduces the risk of relapse and prolongs survival. Lancet 1998; 351: 700-708 |
| 62. | Stevens RF, Hann IM, Wheatley K, Gray RG on behalf of the MRC Childhood Leukaemia Working Party. Marked improvements in outcome with chemotherapy alone in paediatric acute myeloid leukaemia: results of the United Kingdom Medical Research Council's 10th AML trial. Br J Haematol 1998; 101: 129-139 |
| 63. | Wheeler K, Richards S, Bailey C, Chessells J for the MRC Working Party on Childhood Leukaemia. Comparison of bone marrow transplant and chemotherapy for relapsed childhood acute lymphoblastic leukaemia the MRC UKALL X experience. Br J Haematol 1998; 101: 93-102 |
| 64. | Richards S, Burrett J, Hann I, Chessells J, Hill F, Bailey C for the MRC Working Party on Childhood Leukaemia. Improved survival with early intensification: combined results from the Medical Research Council childhood ALL randomised trials, UKALL X and UKALL XI. Leukaemia 1998; 12: 1031-1036 |
| 65. | UK-TIA Study Group. The United Kingdom transient ischaemic attack (UK-TIA) aspirin trial: final results. J Neurol Neurosurg Psychiatry 1991; 54: 1044-1054 |
| 66. | European Carotid Surgery Trialists' Collaborative Group. MRC European Carotid Surgery Trial: interim results for symptomatic patients with severe (70-99%) or with mild (0-29%) carotid stenosis. Lancet 1991; 337: 1235-1243 |
| 67. | European Carotid Surgery Trialists' Collaborative Group. Endarterectomy for moderate symptomatic carotid stenosis: interim results from the MRC European Carotid Surgery Trial. Lancet 1996; 347: 1591-1593 |
| 68. | European Carotid Surgery Trialists' Collaborative Group. Randomised trial of endarterectomy for recently symptomatic carotid stenosis: final results of the MRC European Carotid Surgery Trial (ECST). Lancet 1998; 351: 1379-1387 |
| 69. | International Stroke Trial Collaborative Group. The International Stroke Trial (IST): a randomised trial of aspirin, subcutaneous heparin, both, or neither among 19,435 patients with acute ischaemic stroke. Lancet 1997; 349: 1569-1581 |
| 70. | CLASP (Collaborative Low-dose Aspirin Study in Pregnancy) Collaborative Group. CLASP: a randomised trial of low-dose aspirin for the prevention and treatment of pre-eclampsia among 9364 pregnant women. Lancet 1994; 343: 619-629 |
| 71. | QUASAR Collaborative Group. No benefits from using levamisole or higher-dose folinic acid with 5-fluorouracil as adjuvant chemotherapy for colorectal cancer. 1999 (in preparation) |
| 72. | Clarke R, Shipley M, Lewington S, Youngman L, Collins R, Marmot M, Peto R. Underestimation of risk associations due to regression dilution in long-term follow-up of prospective studies. Am J Epidemiol 1999; 150: 341-353 |
| 73. | Danesh J, Collins R, Peto R. Chronic infections and coronary heart disease: is there a link? Lancet 1997; 350: 430-436 |
| 74. | Danesh J, Collins R, Appleby P, Peto R. Association of fibrinogen, C-reactive protein, albumin, or leukocyte count with coronary heart disease. JAMA 1998; 279: 1477-1482 |
| 75. | Danesh J, Collins R, Peto R, Lowe GDO. Haematocrit, viscosity, erythrocyte sedimentation rate: meta-analyses of prospective studies. Eur Heart J 1999 (in press) |
| 76. | Darby S, Whitley E, Silcocks P, Thakrar B, Green M, Lomas P, Miles J, Reeves G, Fearn T, Doll R. Risk of lung cancer associated with residential radon exposure in south-west England: a case-control study. Br J Cancer 1998; 78: 394-408 |
| 77. | Parish S, Collins R, Peto R, Youngman L, et al for the International Studies of Infarct Survival (ISIS) Collaborative Group. Cigarette smoking, tar yields, and non-fatal myocardial infarction: 14,000 cases and 32,000 controls in the United Kingdom. BMJ 1995; 311: 471-477 |
| 78. | Parish S, Palmer A, Youngman L, Clark S, Peto R, Collins R. Alcohol consumption and non-fatal myocardial infarction, adjusted for other factors: the ISIS-3 epidemiological enquiry. 1999 (in preparation) |
| 79. | Youngman L, Clark S, Parish S, Palmer A, Peto R, Collins R for the International Studies of Infarct Survival (ISIS) Collaborative Group. Total cholesterol, apolipoproteins A1 and B and non-fatal myocardial infarction: 20,000 cases and controls. 1999 (in preparation) |
| 80. | Danesh J, Youngman L, Clark S, Parish S, Peto R, Collins R for the International Studies of Infarct Survival (ISIS) Collaborative Group. Helicobacter pylori infection and early onset myocardial infarction: case-control and sibling pairs study. BMJ 1999 (in press) |
| 81. | Keavney B, McKenzie C, Parish S, Palmer A, Clark S, Youngman L, Delépine M, Lathrop M, Peto R, Collins R. Large-scale test of hypothesised associations between the angiotensin-converting-enzyme insertion/deletion polymorphism and myocardial infarction in about 5,000 cases and 6,000 controls. Lancet 2000; 355(9202): 434-442 |
| 82. | Keavney B, Parish S, Palmer A, Clark S, Youngman L, Lathrop M, Peto R, Collins R. Large-scale test of hypothesised associations between myocardial infarction and polymorphisms of genes related to fibrinogen or lipids in 5000 cases and 6000 controls. 1999 (in preparation) |
| 83. | Chen J, Campbell TC, Li J, Peto R. Diet, Life-style and Mortality in China. Oxford University Press, 1991 |
| 84. | Liu BQ, Peto R, Chen ZM, Boreham J, Wu YP, Li JY, Campbell TC, Chen JS. Emerging tobacco hazards in China: 1. Retrospective proportional mortality study of one million deaths. BMJ 1998; 317: 1411-1422 |
| 85. | Clarke R, Breeze E, Sherliker P, Shipley M, Youngman L, Fletcher A, Fuhrer R, Leon D, Parish S, Collins R, Marmot M. Design, objectives, and lessons from a pilot 25 year follow up re-survey of survivors in the Whitehall study of London Civil Servants. J Epidemiol & Comm Health 1998; 52: 364-369 |
| 86. | Niu SR, Yang GH, Chen ZM, Wang JL, Wang GH, He XZ, Schoepff H, Boreham J, Pan HC, Peto R. Emerging tobacco hazards in China: 2. Early mortality results from a prospective study. BMJ 1998; 317: 1423-1424 |
| 87. | Antithrombotic Trialists' Collaboration. Collaborative meta-analysis of randomised trials of antiplatelet therapy for prevention of death, myocardial infarction, and stroke in high risk patients. BMJ 2002; 324: 71-86 |
| 88. | Prospective Studies Collaboration. Age-specific relevance of usual blood pressure to vascular mortality: a meta-analysis of individual data for one million adults in 61 prospective studies. Lancet 2002; 360: 1903-13 |
| 89. | Baigent C, Keech A, Kearney PM et al on behalf of the Cholesterol Treatment Trialists' (CTT) Collaborators. Efficacy and safety of cholesterol-lowering treatment: prospective meta-analysis of data from 90056 participants in 14 randomised trials of statins. Lancet 2005; 366: 1267-1278. |
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06-02-2012 12:58 PM
