Prospective blood-based study of 150,000 adults in Mexico
In the Coyoacán and Iztapalapa districts of Mexico City, about 150,000 men and women aged 35 or more were surveyed in their homes (recording smoking, alcohol consumption, weight, height, waist circumference, blood pressure, medical and family history) during 1999-2001, and blood samples collected for long-term frozen storage in the CTSU's liquid nitrogen facility and subsequent analysis. During the first 10 years of follow-up there are expected to be more than 20,000 deaths among those aged 40-69 years (and a further 30,000 deaths during the second decade): with, for example, over 2000 from CHD and 2000-3000 associated with diabetes mellitus (many vascular).
This will allow the age- and sex-specific relevance of established risk factors and of newer risk factors (e.g. various details of the lipid profile, coagulation factors, antioxidants, micronutrients, antibodies, genetic variants, etc) for vascular and other diseases to be studied reliably in "nested" case-control studies. Blood and other baseline characteristics of those individuals who die from these causes would be compared with those of carefully matched controls from within the prospective study.
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