ISIS and PROCARDIS sibling-pair studies of genetic determinants of MI
Previous studies on the genetics of CHD have generally adopted the candidate gene approach, but genes can now be mapped - given large enough family collections - using highly informative markers spaced throughout the genome.
About 4-500 affected sibling-pairs with CHD prior to age 65-70 years have been identified as part of the ISIS case-control study, and are now being genotyped. In addition, the PROCARDIS study is recruiting several thousand affected sibling-pairs with CHD under age 55-60 years, together with surviving parents and any additional siblings, through a network in which CTSU is collaborating with the WTCHG (and other groups in Europe). Molecular genetic screening techniques will be used to identify chromosomal regions linked to susceptibility for early onset CHD, with the aim of going on to identify and characterise novel candidate genes for atherosclerosis.
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