Homocysteine, inflammation and blood rheology in CHD
More than 150 epidemiological and clinical reports on the possible role of various of these factors have been synthesised in several meta-analyses [40,73-75]. More detailed collaborative analyses of individual participant data from observational studies of fibrinogen (Fibrinogen Studies Collaboration) and homocysteine (Homocysteine Studies Collaboration) are also being conducted.
Several observational epidemiological studies are in progress within CTSU to look at blood markers of persistent infection (such as antibodies to Helicobacter pylori, Chlamydia pneumoniae or cytomegalovirus) and of inflammation (such as C-reactive protein). The effects of Helicobacter pylori eradication treatment on risk factors for CHD are also being studied in the 1000-patient ETHER trial.
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